PAIP1 — 37 ClinVar variants
All ClinVar germline PAIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
37 Uncertain significance
Full PAIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PAIP1 p.Ala382Thr Uncertain significance Single submitter
- PAIP1 p.Ala382Val Uncertain significance Single submitter
- PAIP1 p.Ala446Pro Uncertain significance Single submitter
- PAIP1 p.Arg220Cys Uncertain significance Single submitter
- PAIP1 p.Arg239Leu Uncertain significance Single submitter
- PAIP1 p.Arg247Gln Uncertain significance Single submitter
- PAIP1 p.Arg477Gln Uncertain significance Single submitter
- PAIP1 p.Asn108Ser Uncertain significance Single submitter
- PAIP1 p.Asn237Thr Uncertain significance Single submitter
- PAIP1 p.Asp164Asn Uncertain significance Single submitter
- PAIP1 p.Gln234His Uncertain significance Single submitter
- PAIP1 p.Gln234Pro Uncertain significance Single submitter
- PAIP1 p.Gly139Asp Uncertain significance Single submitter
- PAIP1 p.Gly139Ser Uncertain significance Single submitter
- PAIP1 p.Gly139Val Uncertain significance Single submitter
- PAIP1 p.Gly445Arg Uncertain significance Single submitter
- PAIP1 p.His381Gln Uncertain significance Single submitter
- PAIP1 p.Leu304Val Uncertain significance Single submitter
- PAIP1 p.Lys127Arg Uncertain significance Single submitter
- PAIP1 p.Lys468Asn Uncertain significance Single submitter
- PAIP1 p.Met125Thr Uncertain significance Single submitter
- PAIP1 p.Pro233Thr Uncertain significance Single submitter
- PAIP1 p.Pro449Ser Uncertain significance Single submitter
- PAIP1 p.Pro93Leu Uncertain significance Single submitter
- PAIP1 p.Pro97Leu Uncertain significance Single submitter
- PAIP1 p.Ser384Ala Uncertain significance Single submitter
- PAIP1 p.Thr145Pro Uncertain significance Single submitter
- PAIP1 p.Thr157Ala Uncertain significance Single submitter
- PAIP1 p.Thr385Ala Uncertain significance Single submitter
- PAIP1 p.Tyr436Phe Uncertain significance Single submitter
- PAIP1 p.Val352Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All PAIP1 variants
Uncertain significance 37
- p.Ala382Thr Single submitter ⚠
- p.Ala382Val Single submitter ⚠
- p.Ala446Pro Single submitter ⚠
- p.Arg220Cys Single submitter ⚠
- p.Arg239Leu Single submitter ⚠
- p.Arg247Gln Single submitter ⚠
- p.Arg266Leu Single submitter ⚠
- p.Arg477Gln Single submitter ⚠
- p.Asn108Ser Single submitter ⚠
- p.Asn237Thr Single submitter ⚠
- p.Asp164Asn Single submitter ⚠
- p.Asp341His Single submitter ⚠
- p.Gln234His Single submitter ⚠
- p.Gln234Pro Single submitter ⚠
- p.Glu110fs Single submitter
- p.Glu371Gln Single submitter ⚠
- p.Gly139Asp Single submitter ⚠
- p.Gly139Ser Single submitter ⚠
- p.Gly139Val Single submitter ⚠
- p.Gly445Arg Single submitter ⚠
- p.His381Gln Single submitter ⚠
- p.Leu166Val Single submitter ⚠
- p.Leu304Val Single submitter ⚠
- p.Lys127Arg Single submitter ⚠
- p.Lys468Asn Single submitter ⚠
- p.Met125Thr Single submitter ⚠
- p.Pro133Leu Single submitter ⚠
- p.Pro233Thr Single submitter ⚠
- p.Pro449Ser Single submitter ⚠
- p.Pro93Leu Single submitter ⚠
- p.Pro97Leu Single submitter ⚠
- p.Ser384Ala Single submitter ⚠
- p.Thr145Pro Single submitter ⚠
- p.Thr157Ala Single submitter ⚠
- p.Thr385Ala Single submitter ⚠
- p.Tyr436Phe Single submitter ⚠
- p.Val352Ile Single submitter ⚠