PARP10 — 187 ClinVar variants

All ClinVar germline PARP10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 161 flagged for review →

1 Likely pathogenic · 2 Conflicting · 1 Benign · 24 Likely benign · 159 Uncertain significance

Full PARP10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 161

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

PARP10 p.Arg751His Conflicting Single submitter

Predictors lean, ClinVar uncertain 141

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 19

The independent predictors disagree with each other — read with care.

All PARP10 variants

Likely pathogenic 1

p.Thr216fs Single submitter Developmental delay

Conflicting classifications of pathogenicity 2

p.Arg751His Single submitter ⚠
p.Glu829Asp Single submitter

Benign 1

p.Val244= Multiple submitters

Likely benign 24

p.Arg197Cys Multiple submitters ⚠
p.Arg502Gln Multiple submitters
p.Gly158Ser Multiple submitters
p.Ala492Thr Single submitter
p.Arg1021His Single submitter
p.Arg209Cys Single submitter
p.Arg235Gln Single submitter
p.Arg680Gln Single submitter
p.Arg724Gln Single submitter
p.Arg751Cys Single submitter
p.Arg822His Single submitter
p.Arg835Gln Single submitter
p.Asp180Gly Single submitter
p.Glu1005Lys Single submitter
p.Gly810Glu Single submitter
p.Leu370Ser Single submitter
p.Leu949= Single submitter
p.Pro265Leu Single submitter
p.Ser183Pro Single submitter
p.Ser351Leu Single submitter
p.Thr280Ala Single submitter
p.Thr333Ala Single submitter
p.Val53Ile Single submitter
p.Val850= Single submitter

Uncertain significance 159

p.Ala438Thr Single submitter ⚠
p.Ala467Val Single submitter ⚠
p.Ala521Ser Single submitter ⚠
p.Ala521Thr Single submitter ⚠
p.Ala538Thr Single submitter ⚠
p.Ala5Val Single submitter ⚠
p.Ala655Thr Single submitter ⚠
p.Ala725Val Single submitter ⚠
p.Ala752Val Single submitter ⚠
p.Ala779Val Single submitter ⚠
p.Ala798Val Single submitter ⚠
p.Ala836Thr Single submitter ⚠
p.Ala89Glu Single submitter ⚠
p.Ala942Val Single submitter ⚠
p.Ala978Val Single submitter ⚠
p.Arg104Cys Single submitter ⚠
p.Arg130Gln Single submitter ⚠
p.Arg130Trp Single submitter ⚠
p.Arg133Gln Single submitter ⚠
p.Arg133Trp Single submitter ⚠
p.Arg168Gln Single submitter ⚠
p.Arg16Cys Single submitter ⚠
p.Arg173Gln Single submitter ⚠
p.Arg176Cys Single submitter ⚠
p.Arg176His Single submitter ⚠
p.Arg198His Single submitter ⚠
p.Arg34Leu Single submitter ⚠
p.Arg36Cys Single submitter ⚠
p.Arg486Gln Single submitter ⚠
p.Arg486Trp Single submitter ⚠
p.Arg548His Single submitter ⚠
p.Arg615Gln Single submitter ⚠
p.Arg662Gln Single submitter ⚠
p.Arg662Trp Single submitter ⚠
p.Arg724Gly Single submitter ⚠
p.Arg724Pro Single submitter ⚠
p.Arg743Cys Single submitter ⚠
p.Arg743Ser Single submitter ⚠
p.Arg744Cys Single submitter ⚠
p.Arg744His Single submitter ⚠
p.Arg751Leu Single submitter ⚠
p.Arg753His Single submitter ⚠
p.Arg756Trp Single submitter ⚠
p.Arg772Cys Single submitter ⚠
p.Arg780Leu Single submitter ⚠
p.Arg783His Single submitter ⚠
p.Arg835Trp Single submitter ⚠
p.Arg845Cys Single submitter ⚠
p.Arg86Gln Single submitter ⚠
p.Arg90Cys Single submitter ⚠
p.Arg923Ser Single submitter ⚠
p.Arg947Gln Single submitter ⚠
p.Arg958His Single submitter ⚠
p.Asn156Ile Single submitter ⚠
p.Asn936Lys Single submitter ⚠
p.Asp206Asn Single submitter ⚠
p.Asp581Glu Single submitter ⚠
p.Asp61Val Single submitter ⚠
p.Asp976His Single submitter ⚠
p.Asp980Glu Single submitter ⚠
p.Asp980Gly Single submitter ⚠
p.Cys542Tyr Single submitter ⚠
p.Gln232His Single submitter ⚠
p.Gln268Glu Single submitter ⚠
p.Gln315Pro Single submitter ⚠
p.Gln410His Single submitter ⚠
p.Gln440Glu Single submitter ⚠
p.Gln491Glu Single submitter ⚠
p.Gln862Glu Single submitter ⚠
p.Gln929Arg Single submitter ⚠
p.Glu196Gly Single submitter ⚠
p.Glu251Lys Single submitter ⚠
p.Glu25Lys Single submitter ⚠
p.Glu299Lys Single submitter ⚠
p.Glu499Gly Single submitter ⚠
p.Glu603Lys Single submitter ⚠
p.Glu636Gly Single submitter ⚠
p.Glu63Asp Single submitter ⚠
p.Glu651Val Single submitter ⚠
p.Glu665Gln Single submitter ⚠
p.Glu6Asp Single submitter ⚠
p.Glu72Gln Single submitter ⚠
p.Glu821Lys Single submitter ⚠
p.Glu854Lys Single submitter ⚠
p.Gly181Cys Single submitter ⚠
p.Gly212Arg Single submitter ⚠
p.Gly261Arg Single submitter ⚠
p.Gly269Glu Single submitter ⚠
p.Gly302Glu Single submitter ⚠
p.Gly323Asp Single submitter ⚠
p.Gly40Ala Single submitter ⚠
p.Gly526Asp Single submitter ⚠
p.Gly572Asp Single submitter ⚠
p.Gly609Arg Single submitter ⚠
p.Gly701Glu Single submitter ⚠
p.Gly701Trp Single submitter ⚠
p.Gly815Arg Single submitter ⚠
p.Gly828Arg Single submitter ⚠
p.Gly828Glu Single submitter ⚠
p.His264Tyr Single submitter ⚠
p.His359Arg Single submitter ⚠
p.His733Gln Single submitter ⚠
p.Ile319Phe Single submitter ⚠
p.Ile990Asn Single submitter ⚠
p.Leu135Val Single submitter ⚠
p.Leu186Pro Single submitter ⚠
p.Leu277Phe Single submitter ⚠
p.Leu29Phe Single submitter ⚠
p.Leu554Val Single submitter ⚠
p.Leu558Phe Single submitter ⚠
p.Leu570Phe Single submitter ⚠
p.Leu658Val Single submitter ⚠
p.Leu722Val Single submitter ⚠
p.Leu746Val Single submitter ⚠
p.Leu860Pro Single submitter ⚠
p.Lys941Thr Single submitter ⚠
p.Met377Ile Single submitter ⚠
p.Met446Leu Single submitter ⚠
p.Phe220Ile Single submitter ⚠
p.Phe988Val Single submitter ⚠
p.Pro1012Ala Single submitter ⚠
p.Pro19Thr Single submitter ⚠
p.Pro203Ala Single submitter ⚠
p.Pro203Leu Single submitter ⚠
p.Pro408Ser Single submitter ⚠
p.Pro480Arg Single submitter ⚠
p.Pro480Leu Single submitter ⚠
p.Pro647Leu Single submitter ⚠
p.Pro691Ala Single submitter ⚠
p.Pro692Ser Single submitter ⚠
p.Pro935Arg Single submitter ⚠
p.Pro985Thr Single submitter ⚠
p.Ser1016Thr Single submitter ⚠
p.Ser199Asn Single submitter ⚠
p.Ser509Gly Single submitter ⚠
p.Ser927Leu Single submitter ⚠
p.Thr1025Ser Single submitter ⚠
p.Thr216Ile Single submitter ⚠
p.Thr273Ile Single submitter ⚠
p.Thr280Ile Single submitter ⚠
p.Thr553Met Single submitter ⚠
p.Thr55Ala Single submitter ⚠
p.Thr579Asn Single submitter ⚠
p.Thr631Ile Single submitter ⚠
p.Thr738Met Single submitter ⚠
p.Thr807Ile Single submitter ⚠
p.Thr812Met Single submitter ⚠
p.Val149Ile Single submitter ⚠
p.Val164Ala Single submitter ⚠
p.Val217Ile Single submitter ⚠
p.Val363Ile Single submitter ⚠
p.Val368Ala Single submitter ⚠
p.Val382Met Single submitter ⚠
p.Val472Ile Single submitter ⚠
p.Val561Met Single submitter ⚠
p.Val732Ala Single submitter ⚠
p.Val786Leu Single submitter ⚠
p.Val945Leu Single submitter ⚠
p.Val948Leu Single submitter ⚠