PARP8 — 73 ClinVar variants
All ClinVar germline PARP8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
1 Likely benign · 72 Uncertain significance
Full PARP8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PARP8 p.Ala450Ser Uncertain significance Single submitter
- PARP8 p.Ala476Ser Uncertain significance Single submitter
- PARP8 p.Ala759Thr Uncertain significance Single submitter
- PARP8 p.Arg204Gln Uncertain significance Single submitter
- PARP8 p.Arg237Gln Uncertain significance Single submitter
- PARP8 p.Arg319Gln Uncertain significance Single submitter
- PARP8 p.Arg319Trp Uncertain significance Single submitter
- PARP8 p.Arg394Gln Uncertain significance Single submitter
- PARP8 p.Arg488Cys Uncertain significance Single submitter
- PARP8 p.Arg488His Uncertain significance Single submitter
- PARP8 p.Arg845Gln Uncertain significance Single submitter
- PARP8 p.Asn113Asp Uncertain significance Single submitter
- PARP8 p.Asn113Lys Uncertain significance Single submitter
- PARP8 p.Asn131Ser Uncertain significance Single submitter
- PARP8 p.Asn268Tyr Uncertain significance Single submitter
- PARP8 p.Asn810Ser Uncertain significance Single submitter
- PARP8 p.Asp145Gly Uncertain significance Single submitter
- PARP8 p.Asp347Asn Uncertain significance Single submitter
- PARP8 p.Asp487Glu Uncertain significance Single submitter
- PARP8 p.Asp487His Uncertain significance Single submitter
- PARP8 p.Cys376Tyr Uncertain significance Single submitter
- PARP8 p.Gln776Lys Uncertain significance Single submitter
- PARP8 p.Gln826Glu Uncertain significance Single submitter
- PARP8 p.Glu116Val Uncertain significance Single submitter
- PARP8 p.Glu273Asp Uncertain significance Single submitter
- PARP8 p.Gly774Glu Uncertain significance Single submitter
- PARP8 p.His242Leu Uncertain significance Single submitter
- PARP8 p.His360Gln Uncertain significance Single submitter
- PARP8 p.His87Arg Uncertain significance Single submitter
- PARP8 p.Ile105Val Uncertain significance Single submitter
- PARP8 p.Ile208Leu Uncertain significance Single submitter
- PARP8 p.Ile357Val Uncertain significance Single submitter
- PARP8 p.Ile462Leu Uncertain significance Single submitter
- PARP8 p.Ile89Thr Uncertain significance Single submitter
- PARP8 p.Leu475Phe Uncertain significance Single submitter
- PARP8 p.Lys245Arg Uncertain significance Single submitter
- PARP8 p.Lys301Arg Uncertain significance Single submitter
- PARP8 p.Lys427Thr Uncertain significance Single submitter
- PARP8 p.Lys772Arg Uncertain significance Single submitter
- PARP8 p.Pro437Leu Uncertain significance Single submitter
- PARP8 p.Pro448Thr Uncertain significance Single submitter
- PARP8 p.Pro590Arg Uncertain significance Single submitter
- PARP8 p.Pro597Leu Uncertain significance Single submitter
- PARP8 p.Ser190Asn Uncertain significance Single submitter
- PARP8 p.Thr122Ile Uncertain significance Single submitter
- PARP8 p.Thr334Ser Uncertain significance Single submitter
- PARP8 p.Val485Leu Uncertain significance Single submitter
- PARP8 p.Val644Ile Uncertain significance Single submitter
- PARP8 p.Val713Ile Uncertain significance Single submitter
- PARP8 p.Val807Leu Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- PARP8 p.Ala594Val Uncertain significance Single submitter
- PARP8 p.Arg342Gly Uncertain significance Single submitter
- PARP8 p.Arg365His Uncertain significance Single submitter
- PARP8 p.Cys297Arg Uncertain significance Single submitter
- PARP8 p.Gln231His Uncertain significance Single submitter
- PARP8 p.Gln255His Uncertain significance Single submitter
- PARP8 p.Gln826His Uncertain significance Single submitter
- PARP8 p.Glu195Asp Uncertain significance Single submitter
- PARP8 p.Glu418Lys Uncertain significance Single submitter
- PARP8 p.Glu579Lys Uncertain significance Single submitter
- PARP8 p.Gly239Val Uncertain significance Single submitter
- PARP8 p.Gly521Cys Uncertain significance Single submitter
- PARP8 p.Leu461Phe Uncertain significance Single submitter
- PARP8 p.Leu505Ile Uncertain significance Single submitter
- PARP8 p.Phe230Cys Uncertain significance Single submitter
- PARP8 p.Pro279Ser Uncertain significance Single submitter
- PARP8 p.Pro622Arg Uncertain significance Single submitter
- PARP8 p.Tyr175Phe Uncertain significance Single submitter
All PARP8 variants
Likely benign 1
- p.Asn264Ser Single submitter
Uncertain significance 72
- p.Ala450Ser Single submitter ⚠
- p.Ala476Ser Single submitter ⚠
- p.Ala594Val Single submitter ⚠
- p.Ala759Thr Single submitter ⚠
- p.Arg204Gln Single submitter ⚠
- p.Arg237Gln Single submitter ⚠
- p.Arg319Gln Single submitter ⚠
- p.Arg319Trp Single submitter ⚠
- p.Arg342Gly Single submitter ⚠
- p.Arg365His Single submitter ⚠
- p.Arg394Gln Single submitter ⚠
- p.Arg394Pro Single submitter
- p.Arg416Gly Single submitter
- p.Arg416Ile Single submitter
- p.Arg488Cys Single submitter ⚠
- p.Arg488His Single submitter ⚠
- p.Arg845Gln Single submitter ⚠
- p.Asn113Asp Single submitter ⚠
- p.Asn113Lys Single submitter ⚠
- p.Asn131Ser Single submitter ⚠
- p.Asn268Tyr Single submitter ⚠
- p.Asn810Ser Single submitter ⚠
- p.Asp145Gly Single submitter ⚠
- p.Asp347Asn Single submitter ⚠
- p.Asp487Glu Single submitter ⚠
- p.Asp487His Single submitter ⚠
- p.Cys297Arg Single submitter ⚠
- p.Cys376Tyr Single submitter ⚠
- p.Gln231His Single submitter ⚠
- p.Gln255His Single submitter ⚠
- p.Gln776Lys Single submitter ⚠
- p.Gln826Glu Single submitter ⚠
- p.Gln826His Single submitter ⚠
- p.Glu116Val Single submitter ⚠
- p.Glu195Asp Single submitter ⚠
- p.Glu273Asp Single submitter ⚠
- p.Glu418Lys Single submitter ⚠
- p.Glu579Lys Single submitter ⚠
- p.Gly239Val Single submitter ⚠
- p.Gly521Cys Single submitter ⚠
- p.Gly774Glu Single submitter ⚠
- p.His242Leu Single submitter ⚠
- p.His360Gln Single submitter ⚠
- p.His87Arg Single submitter ⚠
- p.Ile105Val Single submitter ⚠
- p.Ile208Leu Single submitter ⚠
- p.Ile357Val Single submitter ⚠
- p.Ile462Leu Single submitter ⚠
- p.Ile89Thr Single submitter ⚠
- p.Leu423Pro Single submitter
- p.Leu461Phe Single submitter ⚠
- p.Leu475Phe Single submitter ⚠
- p.Leu505Ile Single submitter ⚠
- p.Lys245Arg Single submitter ⚠
- p.Lys301Arg Single submitter ⚠
- p.Lys427Thr Single submitter ⚠
- p.Lys772Arg Single submitter ⚠
- p.Phe230Cys Single submitter ⚠
- p.Pro279Ser Single submitter ⚠
- p.Pro437Leu Single submitter ⚠
- p.Pro448Thr Single submitter ⚠
- p.Pro590Arg Single submitter ⚠
- p.Pro597Leu Single submitter ⚠
- p.Pro622Arg Single submitter ⚠
- p.Ser190Asn Single submitter ⚠
- p.Thr122Ile Single submitter ⚠
- p.Thr334Ser Single submitter ⚠
- p.Tyr175Phe Single submitter ⚠
- p.Val485Leu Single submitter ⚠
- p.Val644Ile Single submitter ⚠
- p.Val713Ile Single submitter ⚠
- p.Val807Leu Single submitter ⚠