PDCD11 — 259 ClinVar variants

All ClinVar germline PDCD11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 234 flagged for review →

15 Likely benign · 244 Uncertain significance

Full PDCD11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 234

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 194

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 194

Predictors split 40

The independent predictors disagree with each other — read with care.

All PDCD11 variants

Likely benign 15

p.Ala1538Val Single submitter
p.Ala1554Gly Single submitter
p.Arg1198Gln Single submitter
p.Arg1352Gln Single submitter
p.Arg1468Gln Single submitter
p.Arg701His Single submitter
p.Asn1515Ser Single submitter
p.Asn249= Single submitter
p.Glu699Lys Single submitter
p.Ile896Val Single submitter
p.Leu57= Single submitter
p.Lys1524Gln Single submitter
p.Ser800= Single submitter
p.Thr1270Met Single submitter
p.Thr1514Met Single submitter

Uncertain significance 244

p.Ala1131Gly Single submitter ⚠
p.Ala1202Val Single submitter ⚠
p.Ala1526Gly Single submitter ⚠
p.Ala1526Thr Single submitter ⚠
p.Ala1538Thr Single submitter ⚠
p.Ala1594Val Single submitter ⚠
p.Ala1605Glu Single submitter ⚠
p.Ala1605Thr Single submitter ⚠
p.Ala1741Val Single submitter ⚠
p.Ala220Val Single submitter ⚠
p.Ala2Val Single submitter ⚠
p.Ala366Ser Single submitter ⚠
p.Ala52Gly Single submitter ⚠
p.Ala68Thr Single submitter ⚠
p.Ala709Gly Single submitter ⚠
p.Ala709Pro Single submitter ⚠
p.Ala756Pro Single submitter ⚠
p.Ala756Ser Single submitter ⚠
p.Ala756Val Single submitter ⚠
p.Ala841Asp Single submitter ⚠
p.Ala841Val Single submitter ⚠
p.Arg1091Gln Single submitter ⚠
p.Arg1091Leu Single submitter
p.Arg1121Gln Single submitter ⚠
p.Arg1175Gln Single submitter ⚠
p.Arg1352Trp Single submitter ⚠
p.Arg1383Cys Single submitter ⚠
p.Arg1420Lys Single submitter ⚠
p.Arg1420Trp Single submitter ⚠
p.Arg1427Lys Single submitter ⚠
p.Arg1474Trp Single submitter ⚠
p.Arg1505Trp Single submitter ⚠
p.Arg1590Cys Single submitter ⚠
p.Arg1590His Single submitter ⚠
p.Arg1600Trp Single submitter ⚠
p.Arg1610Leu Single submitter ⚠
p.Arg161Gly Single submitter ⚠
p.Arg1639Cys Single submitter ⚠
p.Arg1720Cys Single submitter
p.Arg1720His Single submitter ⚠
p.Arg1720Pro Single submitter ⚠
p.Arg1737Trp Single submitter ⚠
p.Arg1746Cys Single submitter ⚠
p.Arg1746His Single submitter ⚠
p.Arg1779Gln Single submitter ⚠
p.Arg1779Trp Single submitter ⚠
p.Arg337Pro Single submitter ⚠
p.Arg339Gly Single submitter ⚠
p.Arg346His Single submitter ⚠
p.Arg354His Single submitter ⚠
p.Arg358Gly Single submitter ⚠
p.Arg395Leu Single submitter ⚠
p.Arg395Trp Single submitter ⚠
p.Arg477Ser Single submitter ⚠
p.Arg506Gln Single submitter ⚠
p.Arg691Gln Single submitter ⚠
p.Arg691Ter Single submitter
p.Arg826Cys Single submitter ⚠
p.Arg826His Single submitter ⚠
p.Arg832Gln Single submitter ⚠
p.Arg85Cys Single submitter ⚠
p.Arg881Cys Single submitter ⚠
p.Arg964Cys Single submitter ⚠
p.Asn104Ser Single submitter ⚠
p.Asn1243Ser Single submitter ⚠
p.Asn1389Lys Single submitter ⚠
p.Asn228Lys Single submitter ⚠
p.Asn363Thr Single submitter ⚠
p.Asn563Lys Single submitter
p.Asn563Ser Single submitter ⚠
p.Asn785Ser Single submitter ⚠
p.Asp1290Asn Single submitter ⚠
p.Asp1501Gly Single submitter ⚠
p.Asp1816Gly Single submitter ⚠
p.Asp369Gly Single submitter ⚠
p.Asp370Asn Single submitter ⚠
p.Asp538Asn Single submitter ⚠
p.Asp640Asn Single submitter ⚠
p.Asp719Val Single submitter ⚠
p.Asp806Tyr Single submitter ⚠
p.Asp850Asn Single submitter ⚠
p.Asp871Asn Single submitter ⚠
p.Cys151Trp Single submitter ⚠
p.Gln1150His Single submitter ⚠
p.Gln1278Arg Single submitter ⚠
p.Gln1811His Single submitter ⚠
p.Gln287His Single submitter ⚠
p.Gln475His Single submitter ⚠
p.Gln627Arg Single submitter ⚠
p.Gln838His Single submitter ⚠
p.Gln929Glu Single submitter ⚠
p.Glu1440Lys Single submitter ⚠
p.Glu1481Gly Single submitter ⚠
p.Glu1555Asp Single submitter ⚠
p.Glu1578Asp Single submitter ⚠
p.Glu1593Lys Single submitter ⚠
p.Glu1724Lys Single submitter ⚠
p.Glu1753Ala Single submitter ⚠
p.Glu1759Lys Single submitter ⚠
p.Glu1860Ala Single submitter ⚠
p.Glu60Gln Single submitter ⚠
p.Glu842Lys Single submitter ⚠
p.Glu97Asp Single submitter ⚠
p.Glu97Gln Single submitter ⚠
p.Gly1026Arg Single submitter ⚠
p.Gly1036Arg Single submitter ⚠
p.Gly108Ser Single submitter ⚠
p.Gly1230Glu Single submitter ⚠
p.Gly1374Arg Single submitter
p.Gly1469Asp Single submitter ⚠
p.Gly1470Trp Single submitter ⚠
p.Gly1491Ser Single submitter ⚠
p.Gly1599Val Single submitter ⚠
p.Gly250Arg Single submitter ⚠
p.Gly381Glu Single submitter ⚠
p.Gly414Glu Single submitter ⚠
p.Gly624Glu Single submitter ⚠
p.Gly700Arg Single submitter ⚠
p.Gly754Arg Single submitter ⚠
p.Gly805Glu Single submitter ⚠
p.Gly867Val Single submitter ⚠
p.Gly975Val Single submitter ⚠
p.His342Asn Single submitter ⚠
p.His498Pro Single submitter ⚠
p.His572Pro Single submitter ⚠
p.His772Tyr Single submitter ⚠
p.Ile1106Val Single submitter ⚠
p.Ile1817Met Single submitter ⚠
p.Ile463Leu Single submitter ⚠
p.Ile463Val Single submitter ⚠
p.Ile59Thr Single submitter ⚠
p.Ile688Val Single submitter ⚠
p.Ile733Val Single submitter ⚠
p.Leu1182Arg Single submitter ⚠
p.Leu139Phe Single submitter ⚠
p.Leu1414Phe Single submitter ⚠
p.Leu1546Met Single submitter ⚠
p.Leu1621Val Single submitter ⚠
p.Leu1695Ile Single submitter ⚠
p.Leu275Pro Single submitter
p.Leu32Val Single submitter ⚠
p.Leu607Phe Single submitter ⚠
p.Leu689Phe Single submitter ⚠
p.Leu812Arg Single submitter ⚠
p.Leu840Val Single submitter ⚠
p.Leu922Val Single submitter ⚠
p.Leu935Ser Single submitter ⚠
p.Leu98Pro Single submitter ⚠
p.Lys1081Glu Single submitter ⚠
p.Lys1142Glu Single submitter ⚠
p.Lys1445Asn Single submitter ⚠
p.Lys1489Glu Single submitter ⚠
p.Lys1508Arg Single submitter ⚠
p.Lys1575Thr Single submitter ⚠
p.Lys1719Thr Single submitter ⚠
p.Lys1758Asn Single submitter ⚠
p.Lys245Asn Single submitter ⚠
p.Lys316Arg Single submitter ⚠
p.Lys316Glu Single submitter ⚠
p.Lys387Thr Single submitter ⚠
p.Lys540Arg Single submitter ⚠
p.Lys790Asn Single submitter ⚠
p.Met1003Ile Single submitter ⚠
p.Met147Leu Single submitter ⚠
p.Met1717Ile Single submitter ⚠
p.Met1717Leu Single submitter
p.Met1831Val Single submitter ⚠
p.Met311Leu Single submitter ⚠
p.Met468Ile Single submitter ⚠
p.Met490Leu Single submitter ⚠
p.Met847Ile Single submitter ⚠
p.Phe1537Val Single submitter ⚠
p.Phe1681Cys Single submitter ⚠
p.Phe1734Cys Single submitter ⚠
p.Phe1767Leu Single submitter ⚠
p.Phe748Leu Single submitter ⚠
p.Phe953Leu Single submitter ⚠
p.Phe965Ser Single submitter ⚠
p.Pro1116Leu Single submitter ⚠
p.Pro1172Ser Single submitter ⚠
p.Pro1277Leu Single submitter ⚠
p.Pro280Leu Single submitter ⚠
p.Pro347Ser Single submitter ⚠
p.Pro493Leu Single submitter ⚠
p.Pro582Leu Single submitter ⚠
p.Pro845Leu Single submitter ⚠
p.Pro845Ser Single submitter ⚠
p.Ser1119Arg Single submitter ⚠
p.Ser165Gly Single submitter ⚠
p.Ser1673Phe Single submitter ⚠
p.Ser1799Leu Single submitter
p.Ser254Cys Single submitter ⚠
p.Ser397Arg Single submitter ⚠
p.Ser400Phe Single submitter ⚠
p.Ser575Gly Single submitter ⚠
p.Ser614Gly Single submitter ⚠
p.Ser626Gly Single submitter ⚠
p.Ser800Leu Single submitter ⚠
p.Ser865Asn Single submitter ⚠
p.Ser877Asn Single submitter ⚠
p.Ser943Phe Single submitter
p.Thr1080Ile Single submitter ⚠
p.Thr1087Met Single submitter ⚠
p.Thr1114Asn Single submitter ⚠
p.Thr1183Ser Single submitter ⚠
p.Thr1306Met Single submitter ⚠
p.Thr1378Ile Single submitter ⚠
p.Thr1547Ile Single submitter ⚠
p.Thr1633Met Single submitter ⚠
p.Thr297Met Single submitter ⚠
p.Thr524Ala Single submitter ⚠
p.Thr545Arg Single submitter ⚠
p.Thr647Ala Single submitter ⚠
p.Thr666Ala Single submitter ⚠
p.Thr666Ser Single submitter ⚠
p.Thr839Met Single submitter ⚠
p.Thr947Met Single submitter ⚠
p.Thr979Asn Single submitter ⚠
p.Thr982Ile Single submitter ⚠
p.Tyr1103Cys Single submitter ⚠
p.Tyr555Cys Single submitter ⚠
p.Val1019Met Single submitter ⚠
p.Val1162Met Single submitter ⚠
p.Val1276Ile Single submitter ⚠
p.Val1347Phe Single submitter ⚠
p.Val1405Met Single submitter ⚠
p.Val1516Glu Single submitter ⚠
p.Val153Met Single submitter
p.Val1541Met Single submitter ⚠
p.Val1660Leu Single submitter ⚠
p.Val1685Met Single submitter ⚠
p.Val1763Ile Single submitter ⚠
p.Val1814Ile Single submitter ⚠
p.Val307Glu Single submitter ⚠
p.Val307Met Single submitter ⚠
p.Val405Phe Single submitter ⚠
p.Val480Ile Single submitter ⚠
p.Val711Ile Single submitter ⚠
p.Val744Leu Single submitter ⚠
p.Val744Met Single submitter ⚠
p.Val774Phe Single submitter ⚠
p.Val825Met Single submitter ⚠
p.Val908Ile Single submitter ⚠
p.Val93Leu Single submitter ⚠