PDE7B — 56 ClinVar variants
All ClinVar germline PDE7B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
4 Benign · 1 Benign/Likely benign · 1 Likely benign · 50 Uncertain significance
Full PDE7B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDE7B p.Ala212Pro Uncertain significance Single submitter
- PDE7B p.Ala318Ser Uncertain significance Single submitter
- PDE7B p.Ala318Thr Uncertain significance Single submitter
- PDE7B p.Arg255Gln Uncertain significance Single submitter
- PDE7B p.Arg293Thr Uncertain significance Single submitter
- PDE7B p.Arg347Lys Uncertain significance Single submitter
- PDE7B p.Arg387Gln Uncertain significance Single submitter
- PDE7B p.Arg42His Uncertain significance Single submitter
- PDE7B p.Arg52His Uncertain significance Single submitter
- PDE7B p.Asp18Asn Uncertain significance Single submitter
- PDE7B p.Asp448Asn Uncertain significance Single submitter
- PDE7B p.Cys9Ser Uncertain significance Single submitter
- PDE7B p.Glu343Gln Uncertain significance Single submitter
- PDE7B p.Glu441Asp Uncertain significance Single submitter
- PDE7B p.Glu62Asp Uncertain significance Single submitter
- PDE7B p.Gly425Asp Uncertain significance Single submitter
- PDE7B p.His107Arg Uncertain significance Single submitter
- PDE7B p.His433Leu Uncertain significance Single submitter
- PDE7B p.Ile119Val Uncertain significance Single submitter
- PDE7B p.Ile226Val Uncertain significance Single submitter
- PDE7B p.Ile251Val Uncertain significance Single submitter
- PDE7B p.Ile330Ser Uncertain significance Single submitter
- PDE7B p.Ile375Thr Uncertain significance Single submitter
- PDE7B p.Leu259Val Uncertain significance Single submitter
- PDE7B p.Leu32Gln Uncertain significance Single submitter
- PDE7B p.Leu362Pro Uncertain significance Single submitter
- PDE7B p.Lys190Thr Uncertain significance Single submitter
- PDE7B p.Lys67Glu Uncertain significance Single submitter
- PDE7B p.Lys68Arg Uncertain significance Single submitter
- PDE7B p.Met204Ile Uncertain significance Single submitter
- PDE7B p.Pro371Leu Uncertain significance Single submitter
- PDE7B p.Ser168Arg Uncertain significance Single submitter
- PDE7B p.Ser249Phe Uncertain significance Single submitter
- PDE7B p.Ser338Asn Uncertain significance Single submitter
- PDE7B p.Ser429Asn Uncertain significance Single submitter
- PDE7B p.Ser449Asn Uncertain significance Single submitter
- PDE7B p.Thr154Ile Uncertain significance Single submitter
- PDE7B p.Thr182Asn Uncertain significance Single submitter
- PDE7B p.Tyr78Phe Uncertain significance Single submitter
- PDE7B p.Val241Ala Uncertain significance Single submitter
- PDE7B p.Val38Ile Uncertain significance Single submitter
- PDE7B p.Val38Leu Uncertain significance Single submitter
- PDE7B p.Val69Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- PDE7B p.Arg124Cys Uncertain significance Single submitter
- PDE7B p.Asn129Lys Uncertain significance Single submitter
- PDE7B p.Leu406Val Uncertain significance Single submitter
- PDE7B p.Pro223Gln Uncertain significance Single submitter
- PDE7B p.Pro223Thr Uncertain significance Single submitter
- PDE7B p.Thr199Met Uncertain significance Single submitter
All PDE7B variants
Benign 4
- p.Arg83= Single submitter
- p.His262= Single submitter
- p.Ser449Arg Single submitter
- p.Thr199= Single submitter
Benign/Likely benign 1
- p.Lys295Arg Multiple submitters
Likely benign 1
- p.Leu235= Single submitter
Uncertain significance 50
- p.Ala212Pro Single submitter ⚠
- p.Ala318Ser Single submitter ⚠
- p.Ala318Thr Single submitter ⚠
- p.Arg124Cys Single submitter ⚠
- p.Arg255Gln Single submitter ⚠
- p.Arg293Thr Single submitter ⚠
- p.Arg347Lys Single submitter ⚠
- p.Arg387Gln Single submitter ⚠
- p.Arg42His Single submitter ⚠
- p.Arg52His Single submitter ⚠
- p.Asn129Lys Single submitter ⚠
- p.Asp18Asn Single submitter ⚠
- p.Asp448Asn Single submitter ⚠
- p.Cys9Ser Single submitter ⚠
- p.Glu343Gln Single submitter ⚠
- p.Glu441Asp Single submitter ⚠
- p.Glu62Asp Single submitter ⚠
- p.Gly425Asp Single submitter ⚠
- p.His107Arg Single submitter ⚠
- p.His433Leu Single submitter ⚠
- p.Ile119Val Single submitter ⚠
- p.Ile226Val Single submitter ⚠
- p.Ile251Val Single submitter ⚠
- p.Ile330Ser Single submitter ⚠
- p.Ile375Thr Single submitter ⚠
- p.Leu259Val Single submitter ⚠
- p.Leu32Gln Single submitter ⚠
- p.Leu362Pro Single submitter ⚠
- p.Leu406Val Single submitter ⚠
- p.Lys190Thr Single submitter ⚠
- p.Lys67Glu Single submitter ⚠
- p.Lys68Arg Single submitter ⚠
- p.Met204Ile Single submitter ⚠
- p.Pro223Gln Single submitter ⚠
- p.Pro223Thr Single submitter ⚠
- p.Pro371Leu Single submitter ⚠
- p.Ser168Arg Single submitter ⚠
- p.Ser249Phe Single submitter ⚠
- p.Ser338Asn Single submitter ⚠
- p.Ser429Asn Single submitter ⚠
- p.Ser449Asn Single submitter ⚠
- p.Thr154Ile Single submitter ⚠
- p.Thr182Asn Single submitter ⚠
- p.Thr199Met Single submitter ⚠
- p.Tyr78Phe Single submitter ⚠
- p.Val241Ala Single submitter ⚠
- p.Val38Ile Single submitter ⚠
- p.Val38Leu Single submitter ⚠
- p.Val69Leu Single submitter ⚠
- p.Arg248Ter No assertion criteria prostate cancer