PDIA5 — 85 ClinVar variants
All ClinVar germline PDIA5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 82 flagged for review →
2 Likely benign · 83 Uncertain significance
Full PDIA5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 82
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDIA5 p.Ala133Val Uncertain significance Single submitter
- PDIA5 p.Ala150Val Uncertain significance Single submitter
- PDIA5 p.Ala179Val Uncertain significance Single submitter
- PDIA5 p.Ala334Pro Uncertain significance Single submitter
- PDIA5 p.Ala342Gly Uncertain significance Single submitter
- PDIA5 p.Ala365Thr Uncertain significance Single submitter
- PDIA5 p.Ala384Asp Uncertain significance Single submitter
- PDIA5 p.Ala469Gly Uncertain significance Single submitter
- PDIA5 p.Ala485Ser Uncertain significance Single submitter
- PDIA5 p.Ala59Val Uncertain significance Single submitter
- PDIA5 p.Arg164Gln Uncertain significance Single submitter
- PDIA5 p.Arg200Gln Uncertain significance Single submitter
- PDIA5 p.Arg408Trp Uncertain significance Single submitter
- PDIA5 p.Arg46Gln Uncertain significance Single submitter
- PDIA5 p.Arg492His Uncertain significance Single submitter
- PDIA5 p.Asp137Asn Uncertain significance Single submitter
- PDIA5 p.Asp152Glu Uncertain significance Single submitter
- PDIA5 p.Asp243Asn Uncertain significance Single submitter
- PDIA5 p.Asp273Val Uncertain significance Single submitter
- PDIA5 p.Asp283Asn Uncertain significance Single submitter
- PDIA5 p.Asp446Glu Uncertain significance Single submitter
- PDIA5 p.Cys231Ser Uncertain significance Single submitter
- PDIA5 p.Gln263Arg Uncertain significance Single submitter
- PDIA5 p.Gln380His Uncertain significance Single submitter
- PDIA5 p.Glu170Asp Uncertain significance Single submitter
- PDIA5 p.Glu216Gly Uncertain significance Single submitter
- PDIA5 p.Glu377Lys Uncertain significance Single submitter
- PDIA5 p.Glu506Lys Uncertain significance Single submitter
- PDIA5 p.Glu57Asp Uncertain significance Single submitter
- PDIA5 p.Gly246Glu Uncertain significance Single submitter
- PDIA5 p.Gly276Ser Uncertain significance Single submitter
- PDIA5 p.Gly324Ala Uncertain significance Single submitter
- PDIA5 p.Gly513Ala Uncertain significance Single submitter
- PDIA5 p.Ile131Thr Uncertain significance Single submitter
- PDIA5 p.Ile175Thr Uncertain significance Single submitter
- PDIA5 p.Ile230Val Uncertain significance Single submitter
- PDIA5 p.Ile449Val Uncertain significance Single submitter
- PDIA5 p.Lys107Gln Uncertain significance Single submitter
- PDIA5 p.Lys129Glu Uncertain significance Single submitter
- PDIA5 p.Lys257Asn Uncertain significance Single submitter
- PDIA5 p.Lys312Arg Uncertain significance Single submitter
- PDIA5 p.Lys448Arg Uncertain significance Single submitter
- PDIA5 p.Met420Thr Uncertain significance Single submitter
- PDIA5 p.Pro180Arg Uncertain significance Single submitter
- PDIA5 p.Pro267Ser Uncertain significance Single submitter
- PDIA5 p.Pro386Leu Uncertain significance Single submitter
- PDIA5 p.Ser130Tyr Uncertain significance Single submitter
- PDIA5 p.Ser158Gly Uncertain significance Single submitter
- PDIA5 p.Ser19Pro Uncertain significance Single submitter
- PDIA5 p.Ser398Gly Uncertain significance Single submitter
- PDIA5 p.Thr248Ala Uncertain significance Single submitter
- PDIA5 p.Thr269Ile Uncertain significance Single submitter
- PDIA5 p.Thr410Asn Uncertain significance Single submitter
- PDIA5 p.Thr437Ala Uncertain significance Single submitter
- PDIA5 p.Thr79Ala Uncertain significance Single submitter
- PDIA5 p.Tyr232Phe Uncertain significance Single submitter
- PDIA5 p.Tyr245His Uncertain significance Single submitter
- PDIA5 p.Tyr473Cys Uncertain significance Single submitter
- PDIA5 p.Val126Ala Uncertain significance Single submitter
- PDIA5 p.Val298Ile Uncertain significance Single submitter
- PDIA5 p.Val339Leu Uncertain significance Single submitter
- PDIA5 p.Val403Met Uncertain significance Single submitter
- PDIA5 p.Val419Phe Uncertain significance Single submitter
- PDIA5 p.Val432Phe Uncertain significance Single submitter
- PDIA5 p.Val457Ile Uncertain significance Single submitter
- PDIA5 p.Val49Ile Uncertain significance Single submitter
- PDIA5 p.Val99Ala Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- PDIA5 p.Arg225Cys Uncertain significance Single submitter
- PDIA5 p.Arg492Cys Uncertain significance Single submitter
- PDIA5 p.Gly201Cys Uncertain significance Single submitter
- PDIA5 p.Gly276Arg Uncertain significance Single submitter
- PDIA5 p.His428Leu Uncertain significance Single submitter
- PDIA5 p.His435Arg Uncertain significance Single submitter
- PDIA5 p.Pro172Leu Uncertain significance Single submitter
- PDIA5 p.Pro385Ser Uncertain significance Single submitter
- PDIA5 p.Pro388Ala Uncertain significance Single submitter
- PDIA5 p.Pro388Thr Uncertain significance Single submitter
- PDIA5 p.Pro390Thr Uncertain significance Single submitter
- PDIA5 p.Pro434Leu Uncertain significance Single submitter
- PDIA5 p.Ser158Ile Uncertain significance Single submitter
- PDIA5 p.Thr229Ala Uncertain significance Single submitter
- PDIA5 p.Val335Leu Uncertain significance Single submitter
All PDIA5 variants
Likely benign 2
- p.Ala442Val Single submitter
- p.Ala485Thr Single submitter
Uncertain significance 83
- p.Ala133Val Single submitter ⚠
- p.Ala150Val Single submitter ⚠
- p.Ala179Val Single submitter ⚠
- p.Ala334Pro Single submitter ⚠
- p.Ala342Gly Single submitter ⚠
- p.Ala365Thr Single submitter ⚠
- p.Ala384Asp Single submitter ⚠
- p.Ala469Gly Single submitter ⚠
- p.Ala485Ser Single submitter ⚠
- p.Ala59Val Single submitter ⚠
- p.Arg124Gln Single submitter
- p.Arg164Gln Single submitter ⚠
- p.Arg200Gln Single submitter ⚠
- p.Arg225Cys Single submitter ⚠
- p.Arg408Trp Single submitter ⚠
- p.Arg46Gln Single submitter ⚠
- p.Arg492Cys Single submitter ⚠
- p.Arg492His Single submitter ⚠
- p.Asp137Asn Single submitter ⚠
- p.Asp152Glu Single submitter ⚠
- p.Asp243Asn Single submitter ⚠
- p.Asp273Val Single submitter ⚠
- p.Asp283Asn Single submitter ⚠
- p.Asp446Glu Single submitter ⚠
- p.Cys231Ser Single submitter ⚠
- p.Gln263Arg Single submitter ⚠
- p.Gln380His Single submitter ⚠
- p.Glu170Asp Single submitter ⚠
- p.Glu216Gly Single submitter ⚠
- p.Glu377Lys Single submitter ⚠
- p.Glu506Lys Single submitter ⚠
- p.Glu57Asp Single submitter ⚠
- p.Gly201Cys Single submitter ⚠
- p.Gly246Glu Single submitter ⚠
- p.Gly276Arg Single submitter ⚠
- p.Gly276Ser Single submitter ⚠
- p.Gly324Ala Single submitter ⚠
- p.Gly513Ala Single submitter ⚠
- p.His428Leu Single submitter ⚠
- p.His435Arg Single submitter ⚠
- p.Ile131Thr Single submitter ⚠
- p.Ile175Thr Single submitter ⚠
- p.Ile230Val Single submitter ⚠
- p.Ile449Val Single submitter ⚠
- p.Lys107Gln Single submitter ⚠
- p.Lys129Glu Single submitter ⚠
- p.Lys257Asn Single submitter ⚠
- p.Lys312Arg Single submitter ⚠
- p.Lys448Arg Single submitter ⚠
- p.Met420Thr Single submitter ⚠
- p.Pro172Leu Single submitter ⚠
- p.Pro180Arg Single submitter ⚠
- p.Pro267Ser Single submitter ⚠
- p.Pro385Ser Single submitter ⚠
- p.Pro386Leu Single submitter ⚠
- p.Pro388Ala Single submitter ⚠
- p.Pro388Thr Single submitter ⚠
- p.Pro390Thr Single submitter ⚠
- p.Pro434Leu Single submitter ⚠
- p.Ser130Tyr Single submitter ⚠
- p.Ser158Gly Single submitter ⚠
- p.Ser158Ile Single submitter ⚠
- p.Ser19Pro Single submitter ⚠
- p.Ser398Gly Single submitter ⚠
- p.Thr229Ala Single submitter ⚠
- p.Thr248Ala Single submitter ⚠
- p.Thr269Ile Single submitter ⚠
- p.Thr410Asn Single submitter ⚠
- p.Thr437Ala Single submitter ⚠
- p.Thr79Ala Single submitter ⚠
- p.Tyr232Phe Single submitter ⚠
- p.Tyr245His Single submitter ⚠
- p.Tyr473Cys Single submitter ⚠
- p.Val126Ala Single submitter ⚠
- p.Val298Ile Single submitter ⚠
- p.Val335Leu Single submitter ⚠
- p.Val339Leu Single submitter ⚠
- p.Val403Met Single submitter ⚠
- p.Val419Phe Single submitter ⚠
- p.Val432Phe Single submitter ⚠
- p.Val457Ile Single submitter ⚠
- p.Val49Ile Single submitter ⚠
- p.Val99Ala Single submitter ⚠