Sugi Variant

Sugi Variant/PIK3CA

PIK3CA — 1526 ClinVar variants

All ClinVar germline PIK3CA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 643 flagged for review →

44 Pathogenic · 24 Pathogenic/Likely pathogenic · 48 Likely pathogenic · 30 Conflicting · 50 Benign · 12 Benign/Likely benign · 653 Likely benign · 665 Uncertain significance

Full PIK3CA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 643

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 10

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 18

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 407

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 407

Predictors split 208

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 208

All PIK3CA variants

Pathogenic 44

Pathogenic/Likely pathogenic 24

Likely pathogenic 48

Conflicting classifications of pathogenicity 30

Benign 50

Benign/Likely benign 12

Likely benign 653

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 665

Showing the top 300 by review status; the full set is in the sitemap.