PLAAT5 — 38 ClinVar variants
All ClinVar germline PLAAT5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
2 Likely benign · 36 Uncertain significance
Full PLAAT5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLAAT5 p.Ala257Gly Uncertain significance Single submitter
- PLAAT5 p.Arg14His Uncertain significance Single submitter
- PLAAT5 p.Arg14Ser Uncertain significance Single submitter
- PLAAT5 p.Arg167Gln Uncertain significance Single submitter
- PLAAT5 p.Arg17Gly Uncertain significance Single submitter
- PLAAT5 p.Arg236Gln Uncertain significance Single submitter
- PLAAT5 p.Asp96Asn Uncertain significance Single submitter
- PLAAT5 p.Gln239Lys Uncertain significance Single submitter
- PLAAT5 p.Gln60Arg Uncertain significance Single submitter
- PLAAT5 p.Gln73His Uncertain significance Single submitter
- PLAAT5 p.Glu10Val Uncertain significance Single submitter
- PLAAT5 p.Gly181Ser Uncertain significance Single submitter
- PLAAT5 p.Gly2Ser Uncertain significance Single submitter
- PLAAT5 p.His147Tyr Uncertain significance Single submitter
- PLAAT5 p.Ile126Asn Uncertain significance Single submitter
- PLAAT5 p.Ile128Ser Uncertain significance Single submitter
- PLAAT5 p.Ile131Thr Uncertain significance Single submitter
- PLAAT5 p.Ile213Val Uncertain significance Single submitter
- PLAAT5 p.Ile219Thr Uncertain significance Single submitter
- PLAAT5 p.Ile255Val Uncertain significance Single submitter
- PLAAT5 p.Lys212Arg Uncertain significance Single submitter
- PLAAT5 p.Lys24Asn Uncertain significance Single submitter
- PLAAT5 p.Pro235Ser Uncertain significance Single submitter
- PLAAT5 p.Pro5Leu Uncertain significance Single submitter
- PLAAT5 p.Ser27Trp Uncertain significance Single submitter
- PLAAT5 p.Ser52Pro Uncertain significance Single submitter
- PLAAT5 p.Ser92Arg Uncertain significance Single submitter
- PLAAT5 p.Tyr133Cys Uncertain significance Single submitter
- PLAAT5 p.Tyr216Cys Uncertain significance Single submitter
- PLAAT5 p.Val234Ile Uncertain significance Single submitter
- PLAAT5 p.Val59Gly Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All PLAAT5 variants
Likely benign 2
- p.His242= Single submitter
- p.Pro62Leu Single submitter
Uncertain significance 36
- p.Ala243Asp Single submitter ⚠
- p.Ala257Gly Single submitter ⚠
- p.Arg14His Single submitter ⚠
- p.Arg14Ser Single submitter ⚠
- p.Arg167Gln Single submitter ⚠
- p.Arg167Trp Single submitter ⚠
- p.Arg17Gly Single submitter ⚠
- p.Arg236Gln Single submitter ⚠
- p.Arg236Trp Single submitter ⚠
- p.Asp96Asn Single submitter ⚠
- p.Gln239Lys Single submitter ⚠
- p.Gln60Arg Single submitter ⚠
- p.Gln73His Single submitter ⚠
- p.Glu10Val Single submitter ⚠
- p.Glu153Gln Single submitter ⚠
- p.Gly181Ser Single submitter ⚠
- p.Gly2Ser Single submitter ⚠
- p.His147Tyr Single submitter ⚠
- p.Ile126Asn Single submitter ⚠
- p.Ile128Ser Single submitter ⚠
- p.Ile131Thr Single submitter ⚠
- p.Ile213Val Single submitter ⚠
- p.Ile219Thr Single submitter ⚠
- p.Ile255Val Single submitter ⚠
- p.Lys212Arg Single submitter ⚠
- p.Lys24Asn Single submitter ⚠
- p.Pro151Gln Single submitter ⚠
- p.Pro235Ser Single submitter ⚠
- p.Pro5Leu Single submitter ⚠
- p.Ser27Trp Single submitter ⚠
- p.Ser52Pro Single submitter ⚠
- p.Ser92Arg Single submitter ⚠
- p.Tyr133Cys Single submitter ⚠
- p.Tyr216Cys Single submitter ⚠
- p.Val234Ile Single submitter ⚠
- p.Val59Gly Single submitter ⚠