PLIN5 — 132 ClinVar variants
All ClinVar germline PLIN5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 119 flagged for review →
8 Likely benign · 124 Uncertain significance
Full PLIN5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 119
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 102
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLIN5 p.Pro452Leu Uncertain significance Multiple submitters
- PLIN5 p.Ala174Val Uncertain significance Single submitter
- PLIN5 p.Ala232Thr Uncertain significance Single submitter
- PLIN5 p.Ala232Val Uncertain significance Single submitter
- PLIN5 p.Ala310Thr Uncertain significance Single submitter
- PLIN5 p.Ala341Val Uncertain significance Single submitter
- PLIN5 p.Ala356Ser Uncertain significance Single submitter
- PLIN5 p.Ala356Thr Uncertain significance Single submitter
- PLIN5 p.Ala379Val Uncertain significance Single submitter
- PLIN5 p.Ala38Glu Uncertain significance Single submitter
- PLIN5 p.Ala38Thr Uncertain significance Single submitter
- PLIN5 p.Ala38Val Uncertain significance Single submitter
- PLIN5 p.Ala46Thr Uncertain significance Single submitter
- PLIN5 p.Ala75Thr Uncertain significance Single submitter
- PLIN5 p.Ala93Val Uncertain significance Single submitter
- PLIN5 p.Arg134Gln Uncertain significance Single submitter
- PLIN5 p.Arg134Trp Uncertain significance Single submitter
- PLIN5 p.Arg137Gln Uncertain significance Single submitter
- PLIN5 p.Arg137Pro Uncertain significance Single submitter
- PLIN5 p.Arg138His Uncertain significance Single submitter
- PLIN5 p.Arg145Cys Uncertain significance Single submitter
- PLIN5 p.Arg145His Uncertain significance Single submitter
- PLIN5 p.Arg145Pro Uncertain significance Single submitter
- PLIN5 p.Arg226Leu Uncertain significance Single submitter
- PLIN5 p.Arg25Pro Uncertain significance Single submitter
- PLIN5 p.Arg269His Uncertain significance Single submitter
- PLIN5 p.Arg274His Uncertain significance Single submitter
- PLIN5 p.Arg275Leu Uncertain significance Single submitter
- PLIN5 p.Arg276Trp Uncertain significance Single submitter
- PLIN5 p.Arg288Cys Uncertain significance Single submitter
- PLIN5 p.Arg288Leu Uncertain significance Single submitter
- PLIN5 p.Arg306Gln Uncertain significance Single submitter
- PLIN5 p.Arg320Gln Uncertain significance Single submitter
- PLIN5 p.Arg321Cys Uncertain significance Single submitter
- PLIN5 p.Arg321His Uncertain significance Single submitter
- PLIN5 p.Arg334Cys Uncertain significance Single submitter
- PLIN5 p.Arg334His Uncertain significance Single submitter
- PLIN5 p.Arg406Cys Uncertain significance Single submitter
- PLIN5 p.Arg406His Uncertain significance Single submitter
- PLIN5 p.Arg58His Uncertain significance Single submitter
- PLIN5 p.Arg70Cys Uncertain significance Single submitter
- PLIN5 p.Asp120Val Uncertain significance Single submitter
- PLIN5 p.Asp391Asn Uncertain significance Single submitter
- PLIN5 p.Asp41Asn Uncertain significance Single submitter
- PLIN5 p.Asp73Gly Uncertain significance Single submitter
- PLIN5 p.Cys255Tyr Uncertain significance Single submitter
- PLIN5 p.Gln109Lys Uncertain significance Single submitter
- PLIN5 p.Glu102Asp Uncertain significance Single submitter
- PLIN5 p.Glu142Ala Uncertain significance Single submitter
- PLIN5 p.Glu189Val Uncertain significance Single submitter
- PLIN5 p.Glu214Lys Uncertain significance Single submitter
- PLIN5 p.Glu261Lys Uncertain significance Single submitter
- PLIN5 p.Glu265Lys Uncertain significance Single submitter
- PLIN5 p.Glu460Gln Uncertain significance Single submitter
- PLIN5 p.Gly182Asp Uncertain significance Single submitter
- PLIN5 p.Gly202Cys Uncertain significance Single submitter
- PLIN5 p.Gly247Glu Uncertain significance Single submitter
- PLIN5 p.Gly267Asp Uncertain significance Single submitter
- PLIN5 p.Gly349Asp Uncertain significance Single submitter
- PLIN5 p.Gly401Arg Uncertain significance Single submitter
- PLIN5 p.Gly402Cys Uncertain significance Single submitter
- PLIN5 p.Gly428Glu Uncertain significance Single submitter
- PLIN5 p.Gly430Glu Uncertain significance Single submitter
- PLIN5 p.Gly439Arg Uncertain significance Single submitter
- PLIN5 p.Gly439Trp Uncertain significance Single submitter
- PLIN5 p.His149Asp Uncertain significance Single submitter
- PLIN5 p.His210Asp Uncertain significance Single submitter
- PLIN5 p.His260Gln Uncertain significance Single submitter
- PLIN5 p.His353Asp Uncertain significance Single submitter
- PLIN5 p.Leu201Pro Uncertain significance Single submitter
- PLIN5 p.Leu395Val Uncertain significance Single submitter
- PLIN5 p.Lys315Arg Uncertain significance Single submitter
- PLIN5 p.Met435Arg Uncertain significance Single submitter
- PLIN5 p.Pro10Ser Uncertain significance Single submitter
- PLIN5 p.Pro253Leu Uncertain significance Single submitter
- PLIN5 p.Pro388His Uncertain significance Single submitter
- PLIN5 p.Pro390His Uncertain significance Single submitter
- PLIN5 p.Pro403Ser Uncertain significance Single submitter
- PLIN5 p.Pro446Leu Uncertain significance Single submitter
- PLIN5 p.Ser111Leu Uncertain significance Single submitter
- PLIN5 p.Ser124Gly Uncertain significance Single submitter
- PLIN5 p.Ser12Cys Uncertain significance Single submitter
- PLIN5 p.Ser187Trp Uncertain significance Single submitter
- PLIN5 p.Ser2Thr Uncertain significance Single submitter
- PLIN5 p.Thr169Met Uncertain significance Single submitter
- PLIN5 p.Thr291Ala Uncertain significance Single submitter
- PLIN5 p.Thr291Ile Uncertain significance Single submitter
- PLIN5 p.Thr37Ile Uncertain significance Single submitter
- PLIN5 p.Val114Leu Uncertain significance Single submitter
- PLIN5 p.Val121Met Uncertain significance Single submitter
- PLIN5 p.Val151Ala Uncertain significance Single submitter
- PLIN5 p.Val199Ala Uncertain significance Single submitter
- PLIN5 p.Val23Leu Uncertain significance Single submitter
- PLIN5 p.Val298Ile Uncertain significance Single submitter
- PLIN5 p.Val316Met Uncertain significance Single submitter
- PLIN5 p.Val351Met Uncertain significance Single submitter
- PLIN5 p.Val358Met Uncertain significance Single submitter
- PLIN5 p.Val365Leu Uncertain significance Single submitter
- PLIN5 p.Val369Met Uncertain significance Single submitter
- PLIN5 p.Val383Met Uncertain significance Single submitter
- PLIN5 p.Val437Phe Uncertain significance Single submitter
- PLIN5 p.Val64Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- PLIN5 p.Ala175Pro Uncertain significance Single submitter
- PLIN5 p.Arg209Cys Uncertain significance Single submitter
- PLIN5 p.Arg209His Uncertain significance Single submitter
- PLIN5 p.Arg25His Uncertain significance Single submitter
- PLIN5 p.Arg348Trp Uncertain significance Single submitter
- PLIN5 p.Glu101Gly Uncertain significance Single submitter
- PLIN5 p.Gly347Asp Uncertain significance Single submitter
- PLIN5 p.Phe198Leu Uncertain significance Single submitter
- PLIN5 p.Phe330Leu Uncertain significance Single submitter
- PLIN5 p.Phe463Leu Uncertain significance Single submitter
- PLIN5 p.Pro167Ala Uncertain significance Single submitter
- PLIN5 p.Pro77Leu Uncertain significance Single submitter
- PLIN5 p.Ser55Phe Uncertain significance Single submitter
- PLIN5 p.Thr35Met Uncertain significance Single submitter
- PLIN5 p.Val22Met Uncertain significance Single submitter
- PLIN5 p.Val339Met Uncertain significance Single submitter
- PLIN5 p.Val64Met Uncertain significance Single submitter
All PLIN5 variants
Likely benign 8
- p.Ala310Pro Single submitter
- p.Ala343Val Single submitter
- p.Arg269Cys Single submitter
- p.Glu299Asp Single submitter
- p.Pro271Leu Single submitter
- p.Val147Met Single submitter
- p.Val151Met Single submitter
- p.Val22= Single submitter
Uncertain significance 124
- p.Pro452Leu Multiple submitters ⚠
- p.Ala174Val Single submitter ⚠
- p.Ala175Pro Single submitter ⚠
- p.Ala232Thr Single submitter ⚠
- p.Ala232Val Single submitter ⚠
- p.Ala310Thr Single submitter ⚠
- p.Ala341Val Single submitter ⚠
- p.Ala356Ser Single submitter ⚠
- p.Ala356Thr Single submitter ⚠
- p.Ala379Val Single submitter ⚠
- p.Ala38Glu Single submitter ⚠
- p.Ala38Thr Single submitter ⚠
- p.Ala38Val Single submitter ⚠
- p.Ala46Thr Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Ala93Val Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg134Trp Single submitter ⚠
- p.Arg137Gln Single submitter ⚠
- p.Arg137Pro Single submitter ⚠
- p.Arg138His Single submitter ⚠
- p.Arg145Cys Single submitter ⚠
- p.Arg145His Single submitter ⚠
- p.Arg145Pro Single submitter ⚠
- p.Arg200Cys Single submitter
- p.Arg209Cys Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg226Leu Single submitter ⚠
- p.Arg25Cys Single submitter
- p.Arg25His Single submitter ⚠
- p.Arg25Pro Single submitter ⚠
- p.Arg269His Single submitter ⚠
- p.Arg274His Single submitter ⚠
- p.Arg275Leu Single submitter ⚠
- p.Arg276Trp Single submitter ⚠
- p.Arg288Cys Single submitter ⚠
- p.Arg288Leu Single submitter ⚠
- p.Arg306Gln Single submitter ⚠
- p.Arg320Gln Single submitter ⚠
- p.Arg321Cys Single submitter ⚠
- p.Arg321His Single submitter ⚠
- p.Arg334Cys Single submitter ⚠
- p.Arg334His Single submitter ⚠
- p.Arg348Trp Single submitter ⚠
- p.Arg406Cys Single submitter ⚠
- p.Arg406His Single submitter ⚠
- p.Arg58His Single submitter ⚠
- p.Arg70Cys Single submitter ⚠
- p.Asp120Val Single submitter ⚠
- p.Asp391Asn Single submitter ⚠
- p.Asp41Asn Single submitter ⚠
- p.Asp73Gly Single submitter ⚠
- p.Cys255Tyr Single submitter ⚠
- p.Cys94Tyr Single submitter
- p.Gln109Lys Single submitter ⚠
- p.Glu101Gly Single submitter ⚠
- p.Glu102Asp Single submitter ⚠
- p.Glu142Ala Single submitter ⚠
- p.Glu189Val Single submitter ⚠
- p.Glu214Lys Single submitter ⚠
- p.Glu261Lys Single submitter ⚠
- p.Glu265Lys Single submitter ⚠
- p.Glu460Gln Single submitter ⚠
- p.Gly182Asp Single submitter ⚠
- p.Gly202Cys Single submitter ⚠
- p.Gly202Ser Single submitter
- p.Gly247Glu Single submitter ⚠
- p.Gly267Asp Single submitter ⚠
- p.Gly347Asp Single submitter ⚠
- p.Gly349Asp Single submitter ⚠
- p.Gly401Arg Single submitter ⚠
- p.Gly402Cys Single submitter ⚠
- p.Gly428Glu Single submitter ⚠
- p.Gly430Glu Single submitter ⚠
- p.Gly439Arg Single submitter ⚠
- p.Gly439Trp Single submitter ⚠
- p.His149Asp Single submitter ⚠
- p.His210Asp Single submitter ⚠
- p.His260Gln Single submitter ⚠
- p.His353Asp Single submitter ⚠
- p.Leu201Pro Single submitter ⚠
- p.Leu395Val Single submitter ⚠
- p.Lys315Arg Single submitter ⚠
- p.Met435Arg Single submitter ⚠
- p.Phe198Leu Single submitter ⚠
- p.Phe330Leu Single submitter ⚠
- p.Phe463Leu Single submitter ⚠
- p.Pro10Ser Single submitter ⚠
- p.Pro167Ala Single submitter ⚠
- p.Pro253Leu Single submitter ⚠
- p.Pro370Leu Single submitter
- p.Pro388His Single submitter ⚠
- p.Pro390His Single submitter ⚠
- p.Pro403Ser Single submitter ⚠
- p.Pro446Leu Single submitter ⚠
- p.Pro77Leu Single submitter ⚠
- p.Ser111Leu Single submitter ⚠
- p.Ser124Gly Single submitter ⚠
- p.Ser12Cys Single submitter ⚠
- p.Ser187Trp Single submitter ⚠
- p.Ser2Thr Single submitter ⚠
- p.Ser55Phe Single submitter ⚠
- p.Thr169Met Single submitter ⚠
- p.Thr291Ala Single submitter ⚠
- p.Thr291Ile Single submitter ⚠
- p.Thr35Met Single submitter ⚠
- p.Thr37Ile Single submitter ⚠
- p.Val114Leu Single submitter ⚠
- p.Val121Met Single submitter ⚠
- p.Val151Ala Single submitter ⚠
- p.Val199Ala Single submitter ⚠
- p.Val22Met Single submitter ⚠
- p.Val23Leu Single submitter ⚠
- p.Val298Ile Single submitter ⚠
- p.Val316Met Single submitter ⚠
- p.Val339Met Single submitter ⚠
- p.Val351Met Single submitter ⚠
- p.Val358Met Single submitter ⚠
- p.Val365Leu Single submitter ⚠
- p.Val369Met Single submitter ⚠
- p.Val383Met Single submitter ⚠
- p.Val437Phe Single submitter ⚠
- p.Val64Leu Single submitter ⚠
- p.Val64Met Single submitter ⚠