PLPP5 — 50 ClinVar variants
All ClinVar germline PLPP5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
4 Likely benign · 46 Uncertain significance
Full PLPP5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLPP5 p.Ala156Pro Uncertain significance Single submitter
- PLPP5 p.Ala22Val Uncertain significance Single submitter
- PLPP5 p.Ala4Glu Uncertain significance Single submitter
- PLPP5 p.Ala5Val Uncertain significance Single submitter
- PLPP5 p.Ala96Pro Uncertain significance Single submitter
- PLPP5 p.Arg115Gly Uncertain significance Single submitter
- PLPP5 p.Arg121Leu Uncertain significance Single submitter
- PLPP5 p.Arg179His Uncertain significance Single submitter
- PLPP5 p.Arg202Gly Uncertain significance Single submitter
- PLPP5 p.Asn100His Uncertain significance Single submitter
- PLPP5 p.Asp137Glu Uncertain significance Single submitter
- PLPP5 p.Asp205His Uncertain significance Single submitter
- PLPP5 p.Asp237Asn Uncertain significance Single submitter
- PLPP5 p.Asp258Ala Uncertain significance Single submitter
- PLPP5 p.Asp263Asn Uncertain significance Single submitter
- PLPP5 p.Cys134Tyr Uncertain significance Single submitter
- PLPP5 p.Cys173Gly Uncertain significance Single submitter
- PLPP5 p.Cys240Arg Uncertain significance Single submitter
- PLPP5 p.Gln38His Uncertain significance Single submitter
- PLPP5 p.His172Tyr Uncertain significance Single submitter
- PLPP5 p.His241Tyr Uncertain significance Single submitter
- PLPP5 p.Ile264Ser Uncertain significance Single submitter
- PLPP5 p.Leu127Val Uncertain significance Single submitter
- PLPP5 p.Leu189Pro Uncertain significance Single submitter
- PLPP5 p.Leu18Phe Uncertain significance Single submitter
- PLPP5 p.Leu20Gln Uncertain significance Single submitter
- PLPP5 p.Leu69Arg Uncertain significance Single submitter
- PLPP5 p.Lys170Asn Uncertain significance Single submitter
- PLPP5 p.Lys3Gln Uncertain significance Single submitter
- PLPP5 p.Phe162Leu Uncertain significance Single submitter
- PLPP5 p.Pro116Arg Uncertain significance Single submitter
- PLPP5 p.Ser147Asn Uncertain significance Single submitter
- PLPP5 p.Ser154Cys Uncertain significance Single submitter
- PLPP5 p.Ser201Cys Uncertain significance Single submitter
- PLPP5 p.Val8Ala Uncertain significance Single submitter
- PLPP5 p.Val8Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- PLPP5 p.Ala98Thr Uncertain significance Single submitter
- PLPP5 p.Arg229Gln Uncertain significance Single submitter
- PLPP5 p.Asp137Tyr Uncertain significance Single submitter
- PLPP5 p.His129Tyr Uncertain significance Single submitter
- PLPP5 p.Lys80Thr Uncertain significance Single submitter
- PLPP5 p.Pro243Ser Uncertain significance Single submitter
- PLPP5 p.Tyr225Cys Uncertain significance Single submitter
All PLPP5 variants
Likely benign 4
- p.Arg84Thr Single submitter
- p.Arg87Lys Single submitter
- p.Ile107Val Single submitter
- p.Thr83Ala Single submitter
Uncertain significance 46
- p.Ala156Pro Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Ala4Glu Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Ala96Pro Single submitter ⚠
- p.Ala98Thr Single submitter ⚠
- p.Arg115Gly Single submitter ⚠
- p.Arg121Leu Single submitter ⚠
- p.Arg179His Single submitter ⚠
- p.Arg202Gly Single submitter ⚠
- p.Arg229Gln Single submitter ⚠
- p.Asn100His Single submitter ⚠
- p.Asp137Glu Single submitter ⚠
- p.Asp137Tyr Single submitter ⚠
- p.Asp205His Single submitter ⚠
- p.Asp237Asn Single submitter ⚠
- p.Asp258Ala Single submitter ⚠
- p.Asp263Asn Single submitter ⚠
- p.Cys134Tyr Single submitter ⚠
- p.Cys173Gly Single submitter ⚠
- p.Cys240Arg Single submitter ⚠
- p.Gln38His Single submitter ⚠
- p.Glu143Asp Single submitter
- p.His129Tyr Single submitter ⚠
- p.His172Tyr Single submitter ⚠
- p.His241Tyr Single submitter ⚠
- p.Ile264Ser Single submitter ⚠
- p.Leu127Val Single submitter ⚠
- p.Leu189Pro Single submitter ⚠
- p.Leu18Phe Single submitter ⚠
- p.Leu20Gln Single submitter ⚠
- p.Leu69Arg Single submitter ⚠
- p.Lys170Asn Single submitter ⚠
- p.Lys3Gln Single submitter ⚠
- p.Lys80Thr Single submitter ⚠
- p.Phe162Leu Single submitter ⚠
- p.Pro116Arg Single submitter ⚠
- p.Pro243Ser Single submitter ⚠
- p.Ser147Asn Single submitter ⚠
- p.Ser154Cys Single submitter ⚠
- p.Ser201Cys Single submitter ⚠
- p.Trp183Leu Single submitter
- p.Tyr225Cys Single submitter ⚠
- p.Tyr231Cys Single submitter
- p.Val8Ala Single submitter ⚠
- p.Val8Leu Single submitter ⚠