POLK — 121 ClinVar variants
All ClinVar germline POLK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 97 flagged for review →
19 Pathogenic · 2 Conflicting · 1 Benign · 7 Likely benign · 92 Uncertain significance
Full POLK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 97
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 9
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
-
POLK p.Asp551Val
Pathogenic
Single submitter
prostate cancer
-
POLK p.Asp581Asn
Pathogenic
Single submitter
prostate cancer
-
POLK p.Asp866Glu
Pathogenic
Single submitter
prostate cancer
-
POLK p.Glu430Gly
Pathogenic
Single submitter
prostate cancer
-
POLK p.Glu449Lys
Pathogenic
Single submitter
prostate cancer
-
POLK p.Ile487Thr
Pathogenic
Single submitter
prostate cancer
-
POLK p.Leu731His
Pathogenic
Single submitter
prostate cancer
-
POLK p.Ser528Cys
Pathogenic
Single submitter
prostate cancer
-
POLK p.Ser678Phe
Pathogenic
Single submitter
prostate cancer
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
POLK p.Ser137Phe
Conflicting
Single submitter
prostate cancer
Predictors lean, ClinVar uncertain 71
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- POLK p.Ala542Gly Uncertain significance Single submitter
- POLK p.Ala677Thr Uncertain significance Single submitter
- POLK p.Ala713Val Uncertain significance Single submitter
- POLK p.Arg175Gln Uncertain significance Single submitter
- POLK p.Arg764His Uncertain significance Single submitter
- POLK p.Asn120Asp Uncertain significance Single submitter
- POLK p.Asn140Asp Uncertain significance Single submitter
- POLK p.Asn270Ser Uncertain significance Single submitter
- POLK p.Asn609Ser Uncertain significance Single submitter
- POLK p.Asn721Ser Uncertain significance Single submitter
- POLK p.Asn795Asp Uncertain significance Single submitter
- POLK p.Asn860Ser Uncertain significance Single submitter
- POLK p.Asp13Gly Uncertain significance Single submitter
- POLK p.Asp187Glu Uncertain significance Single submitter
- POLK p.Asp617Gly Uncertain significance Single submitter
- POLK p.Asp685Gly Uncertain significance Single submitter
- POLK p.Asp705Ala Uncertain significance Single submitter
- POLK p.Asp9Glu Uncertain significance Single submitter
- POLK p.Cys627Ser Uncertain significance Single submitter
- POLK p.Cys661Ser Uncertain significance Single submitter
- POLK p.Cys681Phe Uncertain significance Single submitter
- POLK p.Cys769Ser Uncertain significance Single submitter
- POLK p.Cys8Trp Uncertain significance Single submitter
- POLK p.Gln525Lys Uncertain significance Single submitter
- POLK p.Gln70Arg Uncertain significance Single submitter
- POLK p.Gln85Lys Uncertain significance Single submitter
- POLK p.Glu375Gln Uncertain significance Single submitter
- POLK p.Gly46Glu Uncertain significance Single submitter
- POLK p.His393Tyr Uncertain significance Single submitter
- POLK p.His742Arg Uncertain significance Single submitter
- POLK p.His863Asn Uncertain significance Single submitter
- POLK p.Ile103Val Uncertain significance Single submitter
- POLK p.Ile425Met Uncertain significance Single submitter
- POLK p.Ile458Thr Uncertain significance Single submitter
- POLK p.Leu251Val Uncertain significance Single submitter
- POLK p.Leu680Val Uncertain significance Single submitter
- POLK p.Lys224Glu Uncertain significance Single submitter
- POLK p.Lys552Glu Uncertain significance Single submitter
- POLK p.Lys571Glu Uncertain significance Single submitter
- POLK p.Met28Ile Uncertain significance Single submitter
- POLK p.Met318Thr Uncertain significance Single submitter
- POLK p.Met561Thr Uncertain significance Single submitter
- POLK p.Met606Ile Uncertain significance Single submitter
- POLK p.Met91Val Uncertain significance Single submitter
- POLK p.Phe49Leu Uncertain significance Single submitter
- POLK p.Phe567Cys Uncertain significance Single submitter
- POLK p.Ser10Arg Uncertain significance Single submitter
- POLK p.Ser10Gly Uncertain significance Single submitter
- POLK p.Ser134Gly Uncertain significance Single submitter
- POLK p.Ser310Ile Uncertain significance Single submitter
- POLK p.Ser3Gly Uncertain significance Single submitter
- POLK p.Ser528Gly Uncertain significance Single submitter
- POLK p.Ser592Asn Uncertain significance Single submitter
- POLK p.Ser678Ala Uncertain significance Single submitter
- POLK p.Ser715Asn Uncertain significance Single submitter
- POLK p.Ser715Gly Uncertain significance Single submitter
- POLK p.Ser729Phe Uncertain significance Single submitter
- POLK p.Thr421Ala Uncertain significance Single submitter
- POLK p.Thr582Lys Uncertain significance Single submitter
- POLK p.Thr773Arg Uncertain significance Single submitter
- POLK p.Thr788Ser Uncertain significance Single submitter
- POLK p.Thr839Ala Uncertain significance Single submitter
- POLK p.Tyr141Cys Uncertain significance Single submitter
- POLK p.Tyr174Cys Uncertain significance Single submitter
- POLK p.Val284Leu Uncertain significance Single submitter
- POLK p.Val456Ile Uncertain significance Single submitter
- POLK p.Val474Ala Uncertain significance Single submitter
- POLK p.Val511Ile Uncertain significance Single submitter
- POLK p.Val588Leu Uncertain significance Single submitter
- POLK p.Val669Ile Uncertain significance Single submitter
- POLK p.Val749Phe Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- POLK p.Arg572Pro Uncertain significance Single submitter
- POLK p.Arg63Gln Uncertain significance Single submitter
- POLK p.Asn203Ser Uncertain significance Single submitter
- POLK p.Asn795Ser Uncertain significance Single submitter
- POLK p.Asp348Gly Uncertain significance Single submitter
- POLK p.Gln431Lys Uncertain significance Single submitter
- POLK p.Gln786Lys Uncertain significance Single submitter
- POLK p.Glu180Gly Uncertain significance Single submitter
-
POLK p.Glu29Lys
Conflicting
Single submitter
prostate cancer
- POLK p.Glu375Ala Uncertain significance Single submitter
- POLK p.Ile370Thr Uncertain significance Single submitter
- POLK p.Lys353Arg Uncertain significance Single submitter
- POLK p.Phe628Val Uncertain significance Single submitter
- POLK p.Pro190Leu Uncertain significance Single submitter
- POLK p.Pro350Ala Uncertain significance Single submitter
- POLK p.Pro350Ser Uncertain significance Single submitter
All POLK variants
Pathogenic 19
- c.*66T>C Single submitter prostate cancer
- p.Ala428= Single submitter prostate cancer
- p.Asp551Val Single submitter prostate cancer ⚠
- p.Asp581Asn Single submitter prostate cancer ⚠
- p.Asp866Glu Single submitter prostate cancer ⚠
- p.Gln447= Single submitter prostate cancer
- p.Glu419Gly Single submitter prostate cancer
- p.Glu430Gly Single submitter prostate cancer ⚠
- p.Glu449Lys Single submitter prostate cancer ⚠
- p.Gly154Glu Single submitter prostate cancer
- p.Ile487Thr Single submitter prostate cancer ⚠
- p.Leu442Phe Single submitter prostate cancer
- p.Leu731His Single submitter prostate cancer ⚠
- p.Lys461Glu Single submitter prostate cancer
- p.Lys564= Single submitter prostate cancer
- p.Phe155Ser Single submitter prostate cancer
- p.Phe171Ser Single submitter prostate cancer
- p.Ser528Cys Single submitter prostate cancer ⚠
- p.Ser678Phe Single submitter prostate cancer ⚠
Conflicting classifications of pathogenicity 2
- p.Glu29Lys Single submitter prostate cancer ⚠
- p.Ser137Phe Single submitter prostate cancer ⚠
Benign 1
- p.Asn753= Multiple submitters
Likely benign 7
- p.Glu762= Multiple submitters
- c.-137A>G Single submitter
- c.-99T>A Single submitter
- p.Arg764Cys Single submitter
- p.His406Tyr Single submitter
- p.Lys772Ile Single submitter
- p.Val784Leu Single submitter
Uncertain significance 92
- c.-100A>G Single submitter
- p.Ala381Thr Single submitter
- p.Ala542Gly Single submitter ⚠
- p.Ala677Thr Single submitter ⚠
- p.Ala713Val Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Arg572Pro Single submitter ⚠
- p.Arg63Gln Single submitter ⚠
- p.Arg764His Single submitter ⚠
- p.Asn120Asp Single submitter ⚠
- p.Asn140Asp Single submitter ⚠
- p.Asn203Ser Single submitter ⚠
- p.Asn270Ser Single submitter ⚠
- p.Asn609Ser Single submitter ⚠
- p.Asn721Ser Single submitter ⚠
- p.Asn795Asp Single submitter ⚠
- p.Asn795Ser Single submitter ⚠
- p.Asn860Ser Single submitter ⚠
- p.Asp13Gly Single submitter ⚠
- p.Asp187Glu Single submitter ⚠
- p.Asp348Gly Single submitter ⚠
- p.Asp617Gly Single submitter ⚠
- p.Asp685Gly Single submitter ⚠
- p.Asp705Ala Single submitter ⚠
- p.Asp9Glu Single submitter ⚠
- p.Cys627Ser Single submitter ⚠
- p.Cys661Ser Single submitter ⚠
- p.Cys681Phe Single submitter ⚠
- p.Cys769Ser Single submitter ⚠
- p.Cys8Trp Single submitter ⚠
- p.Gln431Lys Single submitter ⚠
- p.Gln525Lys Single submitter ⚠
- p.Gln70Arg Single submitter ⚠
- p.Gln786Lys Single submitter ⚠
- p.Gln85Lys Single submitter ⚠
- p.Glu180Gly Single submitter ⚠
- p.Glu375Ala Single submitter ⚠
- p.Glu375Gln Single submitter ⚠
- p.Glu57Gly Single submitter
- p.Gly46Glu Single submitter ⚠
- p.His393Tyr Single submitter ⚠
- p.His742Arg Single submitter ⚠
- p.His863Asn Single submitter ⚠
- p.Ile103Val Single submitter ⚠
- p.Ile370Thr Single submitter ⚠
- p.Ile425Met Single submitter ⚠
- p.Ile458Thr Single submitter ⚠
- p.Leu251Val Single submitter ⚠
- p.Leu680Val Single submitter ⚠
- p.Lys224Glu Single submitter ⚠
- p.Lys353Arg Single submitter ⚠
- p.Lys552Glu Single submitter ⚠
- p.Lys571Glu Single submitter ⚠
- p.Met28Ile Single submitter ⚠
- p.Met318Thr Single submitter ⚠
- p.Met561Thr Single submitter ⚠
- p.Met606Ile Single submitter ⚠
- p.Met91Val Single submitter ⚠
- p.Phe49Leu Single submitter ⚠
- p.Phe567Cys Single submitter ⚠
- p.Phe628Val Single submitter ⚠
- p.Pro190Leu Single submitter ⚠
- p.Pro350Ala Single submitter ⚠
- p.Pro350Ser Single submitter ⚠
- p.Ser10Arg Single submitter ⚠
- p.Ser10Gly Single submitter ⚠
- p.Ser134Gly Single submitter ⚠
- p.Ser310Ile Single submitter ⚠
- p.Ser3Gly Single submitter ⚠
- p.Ser528Gly Single submitter ⚠
- p.Ser592Asn Single submitter ⚠
- p.Ser678Ala Single submitter ⚠
- p.Ser715Asn Single submitter ⚠
- p.Ser715Gly Single submitter ⚠
- p.Ser729Phe Single submitter ⚠
- p.Ser735_Phe736insTer Single submitter
- p.Thr421Ala Single submitter ⚠
- p.Thr582Lys Single submitter ⚠
- p.Thr773Arg Single submitter ⚠
- p.Thr788Ile Single submitter
- p.Thr788Ser Single submitter ⚠
- p.Thr839Ala Single submitter ⚠
- p.Trp392Cys Single submitter
- p.Tyr141Cys Single submitter ⚠
- p.Tyr174Cys Single submitter ⚠
- p.Val284Leu Single submitter ⚠
- p.Val456Ile Single submitter ⚠
- p.Val474Ala Single submitter ⚠
- p.Val511Ile Single submitter ⚠
- p.Val588Leu Single submitter ⚠
- p.Val669Ile Single submitter ⚠
- p.Val749Phe Single submitter ⚠