POLL — 105 ClinVar variants
All ClinVar germline POLL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
12 Benign · 11 Likely benign · 82 Uncertain significance
Full POLL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- POLL p.Ala190Gly Uncertain significance Single submitter
- POLL p.Ala535Val Uncertain significance Single submitter
- POLL p.Ala94Thr Uncertain significance Single submitter
- POLL p.Arg123Lys Uncertain significance Single submitter
- POLL p.Arg419Gln Uncertain significance Single submitter
- POLL p.Arg441Trp Uncertain significance Single submitter
- POLL p.Arg487Leu Uncertain significance Single submitter
- POLL p.Arg488His Uncertain significance Single submitter
- POLL p.Arg514Cys Uncertain significance Single submitter
- POLL p.Arg55Gln Uncertain significance Single submitter
- POLL p.Arg568Gln Uncertain significance Single submitter
- POLL p.Arg93Gln Uncertain significance Single submitter
- POLL p.Arg96Cys Uncertain significance Single submitter
- POLL p.Arg96His Uncertain significance Single submitter
- POLL p.Asn284Ser Uncertain significance Single submitter
- POLL p.Asn340Ser Uncertain significance Single submitter
- POLL p.Asp200Gly Uncertain significance Single submitter
- POLL p.Asp326His Uncertain significance Single submitter
- POLL p.Asp429Asn Uncertain significance Single submitter
- POLL p.Cys118Arg Uncertain significance Single submitter
- POLL p.Gln453Arg Uncertain significance Single submitter
- POLL p.Gln464His Uncertain significance Single submitter
- POLL p.Gln471Glu Uncertain significance Single submitter
- POLL p.Gln67Arg Uncertain significance Single submitter
- POLL p.Glu39Gly Uncertain significance Single submitter
- POLL p.Gly304Arg Uncertain significance Single submitter
- POLL p.Gly426Arg Uncertain significance Single submitter
- POLL p.Gly437Ser Uncertain significance Single submitter
- POLL p.Gly468Asp Uncertain significance Single submitter
- POLL p.Ile256Val Uncertain significance Single submitter
- POLL p.Ile283Val Uncertain significance Single submitter
- POLL p.Ile341Val Uncertain significance Single submitter
- POLL p.Leu277Met Uncertain significance Single submitter
- POLL p.Leu461Phe Uncertain significance Single submitter
- POLL p.Met516Thr Uncertain significance Single submitter
- POLL p.Met516Val Uncertain significance Single submitter
- POLL p.Pro105Leu Uncertain significance Single submitter
- POLL p.Pro168Leu Uncertain significance Single submitter
- POLL p.Pro233Ser Uncertain significance Single submitter
- POLL p.Pro244His Uncertain significance Single submitter
- POLL p.Pro552Ser Uncertain significance Single submitter
- POLL p.Ser131Gly Uncertain significance Single submitter
- POLL p.Ser222Phe Uncertain significance Single submitter
- POLL p.Ser339Phe Uncertain significance Single submitter
- POLL p.Ser450Gly Uncertain significance Single submitter
- POLL p.Tyr505Cys Uncertain significance Single submitter
- POLL p.Tyr505Ser Uncertain significance Single submitter
- POLL p.Val125Met Uncertain significance Single submitter
- POLL p.Val399Leu Uncertain significance Single submitter
- POLL p.Val413Met Uncertain significance Single submitter
- POLL p.Val430Met Uncertain significance Single submitter
- POLL p.Val493Leu Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- POLL p.Ala349Val Uncertain significance Single submitter
- POLL p.Ala423Val Uncertain significance Single submitter
- POLL p.Arg308Gln Uncertain significance Single submitter
- POLL p.Arg308Trp Uncertain significance Single submitter
- POLL p.Arg323Gln Uncertain significance Single submitter
- POLL p.Arg323Trp Uncertain significance Single submitter
- POLL p.Arg452Trp Uncertain significance Single submitter
- POLL p.Arg45Trp Uncertain significance Single submitter
- POLL p.Arg478Trp Uncertain significance Single submitter
- POLL p.Arg484Trp Likely benign Single submitter
- POLL p.Arg485Trp Uncertain significance Single submitter
- POLL p.Arg538Gln Uncertain significance Single submitter
- POLL p.Arg538Trp Uncertain significance Single submitter
- POLL p.Gln355Glu Uncertain significance Single submitter
- POLL p.Gly442Ala Uncertain significance Single submitter
- POLL p.His47Pro Uncertain significance Single submitter
- POLL p.His511Arg Uncertain significance Single submitter
- POLL p.Ile305Met Uncertain significance Single submitter
- POLL p.Leu504Phe Uncertain significance Single submitter
- POLL p.Lys544Asn Uncertain significance Single submitter
- POLL p.Phe10Ser Uncertain significance Single submitter
- POLL p.Phe338Leu Uncertain significance Single submitter
- POLL p.Thr81Ser Uncertain significance Single submitter
- POLL p.Tyr267Cys Uncertain significance Single submitter
- POLL p.Val332Met Uncertain significance Single submitter
All POLL variants
Benign 12
- c.1066-135C>A Multiple submitters
- c.1195-62A>G Multiple submitters
- c.1195-6T>C Multiple submitters
- c.573+42A>G Multiple submitters
- c.892-76T>C Multiple submitters
- c.892-95T>C Multiple submitters
- c.*68C>T Multiple submitters
- p.Arg438Trp Multiple submitters
- p.Ser408= Multiple submitters
- p.Thr221Pro Multiple submitters
- c.116-32_116-28del Single submitter
- c.1195-15C>T Single submitter
Likely benign 11
- p.Arg441Gln Single submitter
- p.Arg478Gln Single submitter
- p.Arg484Trp Single submitter ⚠
- p.Asp429= Single submitter
- p.Glu330Asp Single submitter
- p.Ile314Val Single submitter
- p.Pro171Ser Single submitter
- p.Val66Ile Single submitter
- p.Gln120= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
- p.Ile491Val No assertion criteria POLL-related disorder
- p.Ser497Arg No assertion criteria POLL-related disorder
Uncertain significance 82
- p.Ala190Gly Single submitter ⚠
- p.Ala349Val Single submitter ⚠
- p.Ala423Val Single submitter ⚠
- p.Ala535Val Single submitter ⚠
- p.Ala94Thr Single submitter ⚠
- p.Arg123Lys Single submitter ⚠
- p.Arg308Gln Single submitter ⚠
- p.Arg308Trp Single submitter ⚠
- p.Arg323Gln Single submitter ⚠
- p.Arg323Trp Single submitter ⚠
- p.Arg386Cys Single submitter
- p.Arg386His Single submitter
- p.Arg419Gln Single submitter ⚠
- p.Arg441Trp Single submitter ⚠
- p.Arg452Trp Single submitter ⚠
- p.Arg45Trp Single submitter ⚠
- p.Arg478Trp Single submitter ⚠
- p.Arg485Trp Single submitter ⚠
- p.Arg487Gln Single submitter
- p.Arg487Leu Single submitter ⚠
- p.Arg488His Single submitter ⚠
- p.Arg514Cys Single submitter ⚠
- p.Arg538Gln Single submitter ⚠
- p.Arg538Trp Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Arg568Gln Single submitter ⚠
- p.Arg93Gln Single submitter ⚠
- p.Arg96Cys Single submitter ⚠
- p.Arg96His Single submitter ⚠
- p.Asn284Ser Single submitter ⚠
- p.Asn340Ser Single submitter ⚠
- p.Asp200Gly Single submitter ⚠
- p.Asp326His Single submitter ⚠
- p.Asp429Asn Single submitter ⚠
- p.Asp459Gly Single submitter
- p.Cys118Arg Single submitter ⚠
- p.Gln355Glu Single submitter ⚠
- p.Gln453Arg Single submitter ⚠
- p.Gln464His Single submitter ⚠
- p.Gln471Glu Single submitter ⚠
- p.Gln67Arg Single submitter ⚠
- p.Glu39Gly Single submitter ⚠
- p.Gly217Asp Single submitter
- p.Gly304Arg Single submitter ⚠
- p.Gly320Arg Single submitter
- p.Gly426Arg Single submitter ⚠
- p.Gly437Ser Single submitter ⚠
- p.Gly442Ala Single submitter ⚠
- p.Gly468Asp Single submitter ⚠
- p.His47Pro Single submitter ⚠
- p.His511Arg Single submitter ⚠
- p.Ile256Val Single submitter ⚠
- p.Ile283Val Single submitter ⚠
- p.Ile305Met Single submitter ⚠
- p.Ile341Val Single submitter ⚠
- p.Leu277Met Single submitter ⚠
- p.Leu461Phe Single submitter ⚠
- p.Leu504Phe Single submitter ⚠
- p.Lys544Asn Single submitter ⚠
- p.Met516Thr Single submitter ⚠
- p.Met516Val Single submitter ⚠
- p.Phe10Ser Single submitter ⚠
- p.Phe338Leu Single submitter ⚠
- p.Pro105Leu Single submitter ⚠
- p.Pro168Leu Single submitter ⚠
- p.Pro233Ser Single submitter ⚠
- p.Pro244His Single submitter ⚠
- p.Pro552Ser Single submitter ⚠
- p.Ser131Gly Single submitter ⚠
- p.Ser222Phe Single submitter ⚠
- p.Ser339Phe Single submitter ⚠
- p.Ser450Gly Single submitter ⚠
- p.Thr81Ser Single submitter ⚠
- p.Tyr267Cys Single submitter ⚠
- p.Tyr505Cys Single submitter ⚠
- p.Tyr505Ser Single submitter ⚠
- p.Val125Met Single submitter ⚠
- p.Val332Met Single submitter ⚠
- p.Val399Leu Single submitter ⚠
- p.Val413Met Single submitter ⚠
- p.Val430Met Single submitter ⚠
- p.Val493Leu Single submitter ⚠