POLN — 128 ClinVar variants

All ClinVar germline POLN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 110 flagged for review →

2 Conflicting · 3 Benign · 14 Likely benign · 109 Uncertain significance

Full POLN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 110

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 91

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 17

The independent predictors disagree with each other — read with care.

All POLN variants

Conflicting classifications of pathogenicity 2

p.Asp177Tyr Single submitter ⚠
p.Glu182Lys Single submitter ⚠

Benign 3

p.Gln837fs Multiple submitters
p.Phe711Leu Multiple submitters ⚠
p.Pro315Ser Multiple submitters

Likely benign 14

p.Ala683Val Single submitter
p.Arg253Cys Single submitter
p.Arg398Cys Single submitter
p.Arg475Gln Single submitter
p.Arg523Gln Single submitter
p.Gln668His Single submitter
p.Gly133Glu Single submitter
p.Gly191Arg Single submitter
p.His791Arg Single submitter
p.Ile200Val Single submitter
p.Leu435= Single submitter
p.Lys615Glu Single submitter
p.Pro240Leu Single submitter
p.Val666Met Single submitter

Uncertain significance 109

p.Ala472Val Single submitter ⚠
p.Ala672Thr Single submitter ⚠
p.Ala695Pro Single submitter ⚠
p.Ala722Thr Single submitter ⚠
p.Ala750Thr Single submitter ⚠
p.Ala848Thr Single submitter ⚠
p.Arg253His Single submitter ⚠
p.Arg303Trp Single submitter ⚠
p.Arg406Gly Single submitter ⚠
p.Arg425His Single submitter ⚠
p.Arg460His Single submitter ⚠
p.Arg630His Single submitter ⚠
p.Arg723Leu Single submitter ⚠
p.Arg870Cys Single submitter ⚠
p.Asn334Ser Single submitter ⚠
p.Asn387His Single submitter ⚠
p.Asn387Tyr Single submitter ⚠
p.Asn3Ser Single submitter ⚠
p.Asp278Val Single submitter ⚠
p.Asp32Val Single submitter ⚠
p.Asp524Gly Single submitter ⚠
p.Cys280Ser Single submitter ⚠
p.Gln238Lys Single submitter ⚠
p.Gln308Arg Single submitter ⚠
p.Gln422Lys Single submitter ⚠
p.Gln59Arg Single submitter ⚠
p.Gln59His Single submitter ⚠
p.Gln706His Single submitter ⚠
p.Gln713Pro Single submitter ⚠
p.Gln837His Single submitter ⚠
p.Glu428Gln Single submitter ⚠
p.Glu467Lys Single submitter ⚠
p.Glu486Val Single submitter ⚠
p.Glu69Val Single submitter ⚠
p.Glu808Lys Single submitter ⚠
p.Glu835Val Single submitter ⚠
p.Glu872Gln Single submitter ⚠
p.Gly258Val Single submitter ⚠
p.Gly31Asp Single submitter ⚠
p.Gly333Val Single submitter ⚠
p.Gly346Val Single submitter ⚠
p.Gly849Ser Single submitter ⚠
p.Gly863Ser Single submitter ⚠
p.His138Tyr Single submitter ⚠
p.His298Tyr Single submitter ⚠
p.His576Tyr Single submitter ⚠
p.His751Asp Single submitter ⚠
p.His854Tyr Single submitter ⚠
p.Ile200Asn Single submitter ⚠
p.Ile283Val Single submitter ⚠
p.Ile351Thr Single submitter ⚠
p.Ile351Val Single submitter ⚠
p.Ile432Leu Single submitter ⚠
p.Ile434Val Single submitter ⚠
p.Ile478Thr Single submitter ⚠
p.Ile558Ser Single submitter ⚠
p.Ile627Val Single submitter ⚠
p.Ile781Asn Single submitter ⚠
p.Leu250Val Single submitter ⚠
p.Leu329Pro Single submitter ⚠
p.Leu549Phe Single submitter ⚠
p.Leu657Val Single submitter ⚠
p.Leu76Ser Single submitter ⚠
p.Leu820His Single submitter ⚠
p.Lys137Gln Single submitter ⚠
p.Lys530Thr Single submitter ⚠
p.Lys662Thr Single submitter ⚠
p.Met46Val Single submitter ⚠
p.Met825Ile Single submitter ⚠
p.Pro363Leu Single submitter ⚠
p.Pro433Thr Single submitter ⚠
p.Pro512Leu Single submitter ⚠
p.Pro815Leu Single submitter ⚠
p.Pro865Leu Single submitter ⚠
p.Pro890Arg Single submitter ⚠
p.Pro890Leu Single submitter ⚠
p.Pro896Leu Single submitter ⚠
p.Ser190Pro Single submitter ⚠
p.Ser413Cys Single submitter ⚠
p.Ser560Cys Single submitter ⚠
p.Ser560Pro Single submitter ⚠
p.Ser625Pro Single submitter
p.Ser655Phe Single submitter ⚠
p.Ser75Pro Single submitter ⚠
p.Ser81Ala Single submitter ⚠
p.Ser883Thr Single submitter ⚠
p.Ser895Trp Single submitter ⚠
p.Ser93Asn Single submitter ⚠
p.Thr168Ile Single submitter ⚠
p.Thr224Ala Single submitter ⚠
p.Thr378Ile Single submitter ⚠
p.Thr43Ile Single submitter ⚠
p.Thr567Asn Single submitter
p.Thr656Ala Single submitter ⚠
p.Thr794Arg Single submitter ⚠
p.Trp39Arg Single submitter ⚠
p.Tyr227His Single submitter ⚠
p.Tyr282Cys Single submitter ⚠
p.Tyr686Cys Single submitter ⚠
p.Val222Leu Single submitter ⚠
p.Val251Ile Single submitter ⚠
p.Val328Met Single submitter ⚠
p.Val369Ile Single submitter ⚠
p.Val393Met Single submitter ⚠
p.Val48Met Single submitter ⚠
p.Val653Ile Single submitter ⚠
p.Val767Met Single submitter ⚠
p.Val798Met Single submitter ⚠
p.Arg756Gln No assertion criteria prostate cancer ⚠