PPIC — 22 ClinVar variants
All ClinVar germline PPIC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
1 Likely benign · 21 Uncertain significance
Full PPIC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PPIC p.Ala19Val Uncertain significance Single submitter
- PPIC p.Ala210Thr Uncertain significance Single submitter
- PPIC p.Arg6Gln Uncertain significance Single submitter
- PPIC p.Asp200Gly Uncertain significance Single submitter
- PPIC p.Glu115Asp Uncertain significance Single submitter
- PPIC p.Gly130Glu Uncertain significance Single submitter
- PPIC p.Gly25Ala Uncertain significance Single submitter
- PPIC p.Ile129Thr Uncertain significance Single submitter
- PPIC p.Ile209Met Uncertain significance Single submitter
- PPIC p.Leu124Val Uncertain significance Single submitter
- PPIC p.Ser23Pro Uncertain significance Single submitter
- PPIC p.Thr107Pro Uncertain significance Single submitter
- PPIC p.Thr116Ile Uncertain significance Single submitter
- PPIC p.Trp212Gly Uncertain significance Single submitter
- PPIC p.Val161Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- PPIC p.Ala137Thr Uncertain significance Single submitter
- PPIC p.Asp185Glu Uncertain significance Single submitter
- PPIC p.Leu124Met Uncertain significance Single submitter
- PPIC p.Leu20Pro Uncertain significance Single submitter
- PPIC p.Pro34Leu Uncertain significance Single submitter
- PPIC p.Pro34Thr Uncertain significance Single submitter
All PPIC variants
Likely benign 1
- p.Asn190Asp Single submitter
Uncertain significance 21
- p.Ala137Thr Single submitter ⚠
- p.Ala19Val Single submitter ⚠
- p.Ala210Thr Single submitter ⚠
- p.Arg6Gln Single submitter ⚠
- p.Asp185Glu Single submitter ⚠
- p.Asp200Gly Single submitter ⚠
- p.Glu115Asp Single submitter ⚠
- p.Gly130Glu Single submitter ⚠
- p.Gly25Ala Single submitter ⚠
- p.Ile129Thr Single submitter ⚠
- p.Ile209Met Single submitter ⚠
- p.Leu124Met Single submitter ⚠
- p.Leu124Val Single submitter ⚠
- p.Leu20Pro Single submitter ⚠
- p.Pro34Leu Single submitter ⚠
- p.Pro34Thr Single submitter ⚠
- p.Ser23Pro Single submitter ⚠
- p.Thr107Pro Single submitter ⚠
- p.Thr116Ile Single submitter ⚠
- p.Trp212Gly Single submitter ⚠
- p.Val161Ala Single submitter ⚠