PPP6R3 — 98 ClinVar variants
All ClinVar germline PPP6R3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
2 Likely benign · 96 Uncertain significance
Full PPP6R3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PPP6R3 p.Ala410Val Uncertain significance Single submitter
- PPP6R3 p.Ala449Ser Uncertain significance Single submitter
- PPP6R3 p.Ala479Val Uncertain significance Single submitter
- PPP6R3 p.Ala697Ser Uncertain significance Single submitter
- PPP6R3 p.Ala760Val Uncertain significance Single submitter
- PPP6R3 p.Ala768Ser Uncertain significance Single submitter
- PPP6R3 p.Ala783Thr Uncertain significance Single submitter
- PPP6R3 p.Ala846Val Uncertain significance Single submitter
- PPP6R3 p.Arg436Gln Uncertain significance Single submitter
- PPP6R3 p.Arg582Gln Uncertain significance Single submitter
- PPP6R3 p.Arg848Gly Uncertain significance Single submitter
- PPP6R3 p.Asn477Lys Uncertain significance Single submitter
- PPP6R3 p.Asn591Ser Uncertain significance Single submitter
- PPP6R3 p.Asn682Thr Uncertain significance Single submitter
- PPP6R3 p.Asp113Asn Uncertain significance Single submitter
- PPP6R3 p.Asp148Asn Uncertain significance Single submitter
- PPP6R3 p.Asp337His Uncertain significance Single submitter
- PPP6R3 p.Asp414Asn Uncertain significance Single submitter
- PPP6R3 p.Asp490Asn Uncertain significance Single submitter
- PPP6R3 p.Asp734Gly Uncertain significance Single submitter
- PPP6R3 p.Asp752Glu Uncertain significance Single submitter
- PPP6R3 p.Asp778Asn Uncertain significance Single submitter
- PPP6R3 p.Glu205Asp Uncertain significance Single submitter
- PPP6R3 p.Glu30Ala Uncertain significance Single submitter
- PPP6R3 p.Glu318Gln Uncertain significance Single submitter
- PPP6R3 p.Glu64Ala Uncertain significance Single submitter
- PPP6R3 p.Glu710Ala Uncertain significance Single submitter
- PPP6R3 p.Glu855Gln Uncertain significance Single submitter
- PPP6R3 p.Gly615Val Uncertain significance Single submitter
- PPP6R3 p.Gly797Ser Uncertain significance Single submitter
- PPP6R3 p.His455Tyr Uncertain significance Single submitter
- PPP6R3 p.His522Arg Uncertain significance Single submitter
- PPP6R3 p.His8Pro Uncertain significance Single submitter
- PPP6R3 p.Ile153Val Uncertain significance Single submitter
- PPP6R3 p.Ile162Val Uncertain significance Single submitter
- PPP6R3 p.Ile287Val Uncertain significance Single submitter
- PPP6R3 p.Ile372Thr Uncertain significance Single submitter
- PPP6R3 p.Ile399Thr Uncertain significance Single submitter
- PPP6R3 p.Ile45Leu Uncertain significance Single submitter
- PPP6R3 p.Ile575Val Uncertain significance Single submitter
- PPP6R3 p.Ile62Leu Uncertain significance Single submitter
- PPP6R3 p.Ile73Met Uncertain significance Single submitter
- PPP6R3 p.Leu111Ile Uncertain significance Single submitter
- PPP6R3 p.Leu398Pro Uncertain significance Single submitter
- PPP6R3 p.Leu422Phe Uncertain significance Single submitter
- PPP6R3 p.Leu422Ser Uncertain significance Single submitter
- PPP6R3 p.Leu427Ile Uncertain significance Single submitter
- PPP6R3 p.Leu515Pro Uncertain significance Single submitter
- PPP6R3 p.Leu736Ser Uncertain significance Single submitter
- PPP6R3 p.Lys146Gln Uncertain significance Single submitter
- PPP6R3 p.Lys303Arg Uncertain significance Single submitter
- PPP6R3 p.Lys606Gln Uncertain significance Single submitter
- PPP6R3 p.Met163Ile Uncertain significance Single submitter
- PPP6R3 p.Met367Thr Uncertain significance Single submitter
- PPP6R3 p.Met773Val Uncertain significance Single submitter
- PPP6R3 p.Pro324Ser Uncertain significance Single submitter
- PPP6R3 p.Pro338His Uncertain significance Single submitter
- PPP6R3 p.Pro489Arg Uncertain significance Single submitter
- PPP6R3 p.Pro690Thr Uncertain significance Single submitter
- PPP6R3 p.Pro698Ser Uncertain significance Single submitter
- PPP6R3 p.Pro864Ser Uncertain significance Single submitter
- PPP6R3 p.Ser525Thr Uncertain significance Single submitter
- PPP6R3 p.Ser638Phe Uncertain significance Single submitter
- PPP6R3 p.Ser640Leu Uncertain significance Single submitter
- PPP6R3 p.Ser735Cys Uncertain significance Single submitter
- PPP6R3 p.Ser735Phe Uncertain significance Single submitter
- PPP6R3 p.Ser777Cys Uncertain significance Single submitter
- PPP6R3 p.Thr534Met Uncertain significance Single submitter
- PPP6R3 p.Thr801Met Uncertain significance Single submitter
- PPP6R3 p.Thr824Pro Uncertain significance Single submitter
- PPP6R3 p.Thr858Ala Uncertain significance Single submitter
- PPP6R3 p.Val140Leu Uncertain significance Single submitter
- PPP6R3 p.Val469Met Uncertain significance Single submitter
- PPP6R3 p.Val58Ile Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- PPP6R3 p.Ala599Asp Uncertain significance Single submitter
- PPP6R3 p.Ala721Thr Uncertain significance Single submitter
- PPP6R3 p.Arg463Lys Uncertain significance Single submitter
- PPP6R3 p.Asn370Lys Uncertain significance Single submitter
- PPP6R3 p.Asp236Asn Uncertain significance Single submitter
- PPP6R3 p.Gln550His Uncertain significance Single submitter
- PPP6R3 p.Glu246Lys Uncertain significance Single submitter
- PPP6R3 p.Gly285Asp Uncertain significance Single submitter
- PPP6R3 p.Gly452Glu Uncertain significance Single submitter
- PPP6R3 p.Ile80Met Uncertain significance Single submitter
- PPP6R3 p.Leu24Val Uncertain significance Single submitter
- PPP6R3 p.Leu515Val Uncertain significance Single submitter
- PPP6R3 p.Lys155Glu Uncertain significance Single submitter
- PPP6R3 p.Met378Val Uncertain significance Single submitter
- PPP6R3 p.Pro78Ser Uncertain significance Single submitter
- PPP6R3 p.Ser114Phe Uncertain significance Single submitter
- PPP6R3 p.Ser222Gly Uncertain significance Single submitter
- PPP6R3 p.Thr555Met Uncertain significance Single submitter
- PPP6R3 p.Thr649Ile Uncertain significance Single submitter
All PPP6R3 variants
Likely benign 2
- p.Ala863Val Single submitter
- p.Thr669Met Single submitter
Uncertain significance 96
- p.Ala410Val Single submitter ⚠
- p.Ala449Ser Single submitter ⚠
- p.Ala479Val Single submitter ⚠
- p.Ala599Asp Single submitter ⚠
- p.Ala697Ser Single submitter ⚠
- p.Ala721Thr Single submitter ⚠
- p.Ala760Val Single submitter ⚠
- p.Ala768Ser Single submitter ⚠
- p.Ala783Thr Single submitter ⚠
- p.Ala846Val Single submitter ⚠
- p.Arg436Gln Single submitter ⚠
- p.Arg463Lys Single submitter ⚠
- p.Arg582Gln Single submitter ⚠
- p.Arg848Gly Single submitter ⚠
- p.Asn370Lys Single submitter ⚠
- p.Asn477Lys Single submitter ⚠
- p.Asn591Ser Single submitter ⚠
- p.Asn682Thr Single submitter ⚠
- p.Asp113Asn Single submitter ⚠
- p.Asp148Asn Single submitter ⚠
- p.Asp236Asn Single submitter ⚠
- p.Asp337His Single submitter ⚠
- p.Asp414Asn Single submitter ⚠
- p.Asp490Asn Single submitter ⚠
- p.Asp734Gly Single submitter ⚠
- p.Asp752Glu Single submitter ⚠
- p.Asp778Asn Single submitter ⚠
- p.Gln550His Single submitter ⚠
- p.Glu205Asp Single submitter ⚠
- p.Glu246Lys Single submitter ⚠
- p.Glu30Ala Single submitter ⚠
- p.Glu318Gln Single submitter ⚠
- p.Glu55Ter Single submitter
- p.Glu64Ala Single submitter ⚠
- p.Glu710Ala Single submitter ⚠
- p.Glu855Gln Single submitter ⚠
- p.Gly285Asp Single submitter ⚠
- p.Gly285Cys Single submitter
- p.Gly452Glu Single submitter ⚠
- p.Gly615Val Single submitter ⚠
- p.Gly797Ser Single submitter ⚠
- p.His455Tyr Single submitter ⚠
- p.His522Arg Single submitter ⚠
- p.His8Pro Single submitter ⚠
- p.Ile153Val Single submitter ⚠
- p.Ile162Val Single submitter ⚠
- p.Ile287Val Single submitter ⚠
- p.Ile372Thr Single submitter ⚠
- p.Ile399Thr Single submitter ⚠
- p.Ile45Leu Single submitter ⚠
- p.Ile575Val Single submitter ⚠
- p.Ile62Leu Single submitter ⚠
- p.Ile73Met Single submitter ⚠
- p.Ile80Met Single submitter ⚠
- p.Leu111Ile Single submitter ⚠
- p.Leu24Val Single submitter ⚠
- p.Leu398Pro Single submitter ⚠
- p.Leu422Phe Single submitter ⚠
- p.Leu422Ser Single submitter ⚠
- p.Leu427Ile Single submitter ⚠
- p.Leu515Pro Single submitter ⚠
- p.Leu515Val Single submitter ⚠
- p.Leu736Ser Single submitter ⚠
- p.Lys146Gln Single submitter ⚠
- p.Lys155Glu Single submitter ⚠
- p.Lys303Arg Single submitter ⚠
- p.Lys606Gln Single submitter ⚠
- p.Met163Ile Single submitter ⚠
- p.Met367Thr Single submitter ⚠
- p.Met378Val Single submitter ⚠
- p.Met773Val Single submitter ⚠
- p.Pro324Ser Single submitter ⚠
- p.Pro338His Single submitter ⚠
- p.Pro489Arg Single submitter ⚠
- p.Pro690Thr Single submitter ⚠
- p.Pro698Ser Single submitter ⚠
- p.Pro78Ser Single submitter ⚠
- p.Pro864Ser Single submitter ⚠
- p.Ser114Phe Single submitter ⚠
- p.Ser222Gly Single submitter ⚠
- p.Ser525Thr Single submitter ⚠
- p.Ser638Phe Single submitter ⚠
- p.Ser640Leu Single submitter ⚠
- p.Ser735Cys Single submitter ⚠
- p.Ser735Phe Single submitter ⚠
- p.Ser777Cys Single submitter ⚠
- p.Thr534Met Single submitter ⚠
- p.Thr555Met Single submitter ⚠
- p.Thr649Ile Single submitter ⚠
- p.Thr801Met Single submitter ⚠
- p.Thr824Pro Single submitter ⚠
- p.Thr858Ala Single submitter ⚠
- p.Val140Leu Single submitter ⚠
- p.Val182Met Single submitter
- p.Val469Met Single submitter ⚠
- p.Val58Ile Single submitter ⚠