PRAP1 — 24 ClinVar variants
All ClinVar germline PRAP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
24 Uncertain significance
Full PRAP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRAP1 p.Ala47Thr Uncertain significance Single submitter
- PRAP1 p.Arg125Lys Uncertain significance Single submitter
- PRAP1 p.Arg48His Uncertain significance Single submitter
- PRAP1 p.Arg78Gln Uncertain significance Single submitter
- PRAP1 p.Asp108Asn Uncertain significance Single submitter
- PRAP1 p.Asp108His Uncertain significance Single submitter
- PRAP1 p.Asp97Glu Uncertain significance Single submitter
- PRAP1 p.Glu123Lys Uncertain significance Single submitter
- PRAP1 p.Glu141Gln Uncertain significance Single submitter
- PRAP1 p.Glu42Lys Uncertain significance Single submitter
- PRAP1 p.Glu74Lys Uncertain significance Single submitter
- PRAP1 p.Glu75Gly Uncertain significance Single submitter
- PRAP1 p.Gly83Val Uncertain significance Single submitter
- PRAP1 p.His101Tyr Uncertain significance Single submitter
- PRAP1 p.His109Asn Uncertain significance Single submitter
- PRAP1 p.His146Asn Uncertain significance Single submitter
- PRAP1 p.Leu5Ile Uncertain significance Single submitter
- PRAP1 p.Leu70Val Uncertain significance Single submitter
- PRAP1 p.Pro53Arg Uncertain significance Single submitter
- PRAP1 p.Pro68Ser Uncertain significance Single submitter
- PRAP1 p.Pro87Ser Uncertain significance Single submitter
- PRAP1 p.Trp45Arg Uncertain significance Single submitter
- PRAP1 p.Val102Ile Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All PRAP1 variants
Uncertain significance 24
- p.Ala47Thr Single submitter ⚠
- p.Arg125Lys Single submitter ⚠
- p.Arg48His Single submitter ⚠
- p.Arg78Gln Single submitter ⚠
- p.Asp108Asn Single submitter ⚠
- p.Asp108His Single submitter ⚠
- p.Asp97Glu Single submitter ⚠
- p.Glu123Lys Single submitter ⚠
- p.Glu141Gln Single submitter ⚠
- p.Glu42Lys Single submitter ⚠
- p.Glu74Lys Single submitter ⚠
- p.Glu75Gly Single submitter ⚠
- p.Gly83Val Single submitter ⚠
- p.His101Tyr Single submitter ⚠
- p.His109Asn Single submitter ⚠
- p.His146Asn Single submitter ⚠
- p.Leu5Ile Single submitter ⚠
- p.Leu70Val Single submitter ⚠
- p.Pro115Arg Single submitter ⚠
- p.Pro53Arg Single submitter ⚠
- p.Pro68Ser Single submitter ⚠
- p.Pro87Ser Single submitter ⚠
- p.Trp45Arg Single submitter ⚠
- p.Val102Ile Single submitter ⚠