PRCC — 60 ClinVar variants
All ClinVar germline PRCC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
2 Likely benign · 58 Uncertain significance
Full PRCC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
PRCC p.Asp341Gly
Uncertain significance
Multiple submitters
Papillary renal cell carcinoma type 1
- PRCC p.Ala283Thr Uncertain significance Single submitter
- PRCC p.Ala356Thr Uncertain significance Single submitter
- PRCC p.Arg219Thr Uncertain significance Single submitter
- PRCC p.Arg482Cys Uncertain significance Single submitter
- PRCC p.Asn189Ser Uncertain significance Single submitter
- PRCC p.Asp214His Uncertain significance Single submitter
- PRCC p.Asp266Asn Uncertain significance Single submitter
- PRCC p.Asp315Asn Uncertain significance Single submitter
- PRCC p.Asp315Val Uncertain significance Single submitter
- PRCC p.Asp341Asn Uncertain significance Single submitter
- PRCC p.Gln56Leu Uncertain significance Single submitter
- PRCC p.Glu106Lys Uncertain significance Single submitter
- PRCC p.Glu20Asp Uncertain significance Single submitter
- PRCC p.Glu263Gly Uncertain significance Single submitter
- PRCC p.Glu274Lys Uncertain significance Single submitter
- PRCC p.Glu322Asp Uncertain significance Single submitter
- PRCC p.Glu477Asp Uncertain significance Single submitter
- PRCC p.Gly134Arg Uncertain significance Single submitter
- PRCC p.Gly234Val Uncertain significance Single submitter
- PRCC p.Gly37Ser Uncertain significance Single submitter
- PRCC p.His153Asp Uncertain significance Single submitter
- PRCC p.Lys140Glu Uncertain significance Single submitter
- PRCC p.Lys225Asn Uncertain significance Single submitter
- PRCC p.Lys46Arg Uncertain significance Single submitter
- PRCC p.Met57Thr Uncertain significance Single submitter
- PRCC p.Pro19Thr Uncertain significance Single submitter
- PRCC p.Pro208His Uncertain significance Single submitter
- PRCC p.Pro217Ser Uncertain significance Single submitter
- PRCC p.Pro217Thr Uncertain significance Single submitter
- PRCC p.Pro21Ala Uncertain significance Single submitter
- PRCC p.Pro21Leu Uncertain significance Single submitter
- PRCC p.Pro286Ala Uncertain significance Single submitter
- PRCC p.Pro333Arg Uncertain significance Single submitter
- PRCC p.Pro33Ser Uncertain significance Single submitter
- PRCC p.Pro379Ala Uncertain significance Single submitter
- PRCC p.Pro52Ser Uncertain significance Single submitter
- PRCC p.Pro53Ser Uncertain significance Single submitter
- PRCC p.Pro60Thr Uncertain significance Single submitter
- PRCC p.Pro75Thr Uncertain significance Single submitter
- PRCC p.Pro80Leu Uncertain significance Single submitter
- PRCC p.Pro82Leu Uncertain significance Single submitter
- PRCC p.Pro92Gln Uncertain significance Single submitter
- PRCC p.Ser209Leu Uncertain significance Single submitter
- PRCC p.Ser97Arg Uncertain significance Single submitter
- PRCC p.Thr30Ile Uncertain significance Single submitter
- PRCC p.Tyr350His Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- PRCC p.Arg467Gln Uncertain significance Single submitter
- PRCC p.Asp352Val Uncertain significance Single submitter
- PRCC p.Leu279Phe Uncertain significance Single submitter
- PRCC p.Pro201Arg Uncertain significance Single submitter
- PRCC p.Pro240Leu Uncertain significance Single submitter
- PRCC p.Pro240Ser Uncertain significance Single submitter
- PRCC p.Pro80Ser Uncertain significance Single submitter
- PRCC p.Pro82His Uncertain significance Single submitter
-
PRCC p.Ser241Leu
Uncertain significance
Single submitter
Papillary renal cell carcinoma type 1
-
PRCC p.Ser348Phe
Uncertain significance
Single submitter
Papillary renal cell carcinoma type 1
All PRCC variants
Likely benign 2
- p.Ala34Thr Single submitter
- p.Asn121Ser Single submitter
Uncertain significance 58
- p.Asp341Gly Multiple submitters Papillary renal cell carcinoma type 1 ⚠
- p.Ala283Thr Single submitter ⚠
- p.Ala356Thr Single submitter ⚠
- p.Arg219Thr Single submitter ⚠
- p.Arg467Gln Single submitter ⚠
- p.Arg482Cys Single submitter ⚠
- p.Asn189Ser Single submitter ⚠
- p.Asp214His Single submitter ⚠
- p.Asp266Asn Single submitter ⚠
- p.Asp315Asn Single submitter ⚠
- p.Asp315Val Single submitter ⚠
- p.Asp341Asn Single submitter ⚠
- p.Asp352Val Single submitter ⚠
- p.Gln56Leu Single submitter ⚠
- p.Glu106Lys Single submitter ⚠
- p.Glu20Asp Single submitter ⚠
- p.Glu263Gly Single submitter ⚠
- p.Glu274Lys Single submitter ⚠
- p.Glu322Asp Single submitter ⚠
- p.Glu477Asp Single submitter ⚠
- p.Gly134Arg Single submitter ⚠
- p.Gly234Val Single submitter ⚠
- p.Gly37Ser Single submitter ⚠
- p.His153Asp Single submitter ⚠
- p.Leu279Phe Single submitter ⚠
- p.Lys140Glu Single submitter ⚠
- p.Lys225Asn Single submitter ⚠
- p.Lys46Arg Single submitter ⚠
- p.Met57Thr Single submitter ⚠
- p.Pro19Thr Single submitter ⚠
- p.Pro201Arg Single submitter ⚠
- p.Pro208His Single submitter ⚠
- p.Pro217Ser Single submitter ⚠
- p.Pro217Thr Single submitter ⚠
- p.Pro21Ala Single submitter ⚠
- p.Pro21Leu Single submitter ⚠
- p.Pro231fs Single submitter
- p.Pro240Leu Single submitter ⚠
- p.Pro240Ser Single submitter ⚠
- p.Pro286Ala Single submitter ⚠
- p.Pro333Arg Single submitter ⚠
- p.Pro33Ser Single submitter ⚠
- p.Pro379Ala Single submitter ⚠
- p.Pro52Ser Single submitter ⚠
- p.Pro53Ser Single submitter ⚠
- p.Pro60Thr Single submitter ⚠
- p.Pro75Thr Single submitter ⚠
- p.Pro80Leu Single submitter ⚠
- p.Pro80Ser Single submitter ⚠
- p.Pro82His Single submitter ⚠
- p.Pro82Leu Single submitter ⚠
- p.Pro92Gln Single submitter ⚠
- p.Ser209Leu Single submitter ⚠
- p.Ser241Leu Single submitter Papillary renal cell carcinoma type 1 ⚠
- p.Ser348Phe Single submitter Papillary renal cell carcinoma type 1 ⚠
- p.Ser97Arg Single submitter ⚠
- p.Thr30Ile Single submitter ⚠
- p.Tyr350His Single submitter ⚠