PRDX6 — 19 ClinVar variants
All ClinVar germline PRDX6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
1 Benign · 18 Uncertain significance
Full PRDX6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRDX6 p.Arg174Ser Uncertain significance Single submitter
- PRDX6 p.Arg41Gln Uncertain significance Single submitter
- PRDX6 p.Arg41Gly Uncertain significance Single submitter
- PRDX6 p.Arg64Lys Uncertain significance Single submitter
- PRDX6 p.Asp104Gly Uncertain significance Single submitter
- PRDX6 p.Asp105His Uncertain significance Single submitter
- PRDX6 p.Asp123Tyr Uncertain significance Single submitter
- PRDX6 p.Ile147Val Uncertain significance Single submitter
- PRDX6 p.Leu51Val Uncertain significance Single submitter
- PRDX6 p.Lys125Arg Uncertain significance Single submitter
- PRDX6 p.Lys125Asn Uncertain significance Single submitter
- PRDX6 p.Pro139Leu Uncertain significance Single submitter
- PRDX6 p.Ser83Gly Uncertain significance Single submitter
- PRDX6 p.Thr177Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All PRDX6 variants
Benign 1
- c.96-8C>G Multiple submitters
Uncertain significance 18
- p.Arg174Ser Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Arg41Gly Single submitter ⚠
- p.Arg64Lys Single submitter ⚠
- p.Asp104Gly Single submitter ⚠
- p.Asp105His Single submitter ⚠
- p.Asp123Tyr Single submitter ⚠
- p.Asp158Gly Single submitter
- p.Ile147Val Single submitter ⚠
- p.Leu51Val Single submitter ⚠
- p.Lys125Arg Single submitter ⚠
- p.Lys125Asn Single submitter ⚠
- p.Pro139Leu Single submitter ⚠
- p.Pro203Leu Single submitter
- p.Pro94Leu Single submitter ⚠
- p.Ser83Gly Single submitter ⚠
- p.Thr177Ile Single submitter ⚠
- p.Thr192Ile Single submitter ⚠