PRKCZ — 16 ClinVar variants
All ClinVar germline PRKCZ variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 5 flagged for review →
4 Benign · 7 Likely benign · 5 Uncertain significance
Full PRKCZ gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 5
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All PRKCZ variants
Benign 4
- c.688-9C>T Multiple submitters
- p.Arg49His Multiple submitters
- p.Ala358= Single submitter
- p.Thr588= Single submitter
Likely benign 7
Uncertain significance 5
- p.Arg117Trp Single submitter ⚠
- p.Arg260Cys Single submitter ⚠
- p.Arg504Gln Single submitter ⚠
- p.Glu89Gly Single submitter ⚠
- p.Ser218Cys Single submitter ⚠