PRKD3 — 90 ClinVar variants
All ClinVar germline PRKD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →
2 Likely benign · 88 Uncertain significance
Full PRKD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 83
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRKD3 p.Asn882Lys Uncertain significance Multiple submitters
- PRKD3 p.Ala3Ser Uncertain significance Single submitter
- PRKD3 p.Ala511Gly Uncertain significance Single submitter
- PRKD3 p.Arg211Leu Uncertain significance Single submitter
- PRKD3 p.Arg297Cys Uncertain significance Single submitter
- PRKD3 p.Arg355Gln Uncertain significance Single submitter
- PRKD3 p.Arg433Ser Uncertain significance Single submitter
- PRKD3 p.Arg467His Uncertain significance Single submitter
- PRKD3 p.Arg528Cys Uncertain significance Single submitter
- PRKD3 p.Arg725Cys Uncertain significance Single submitter
- PRKD3 p.Arg725Gly Uncertain significance Single submitter
- PRKD3 p.Arg749Trp Uncertain significance Single submitter
- PRKD3 p.Arg755His Uncertain significance Single submitter
- PRKD3 p.Asn120Asp Uncertain significance Single submitter
- PRKD3 p.Asn328Ser Uncertain significance Single submitter
- PRKD3 p.Asn482Ser Uncertain significance Single submitter
- PRKD3 p.Asn754Thr Uncertain significance Single submitter
- PRKD3 p.Asn882His Uncertain significance Single submitter
- PRKD3 p.Asp352Gly Uncertain significance Single submitter
- PRKD3 p.Asp368Val Uncertain significance Single submitter
- PRKD3 p.Asp379Asn Uncertain significance Single submitter
- PRKD3 p.Asp441His Uncertain significance Single submitter
- PRKD3 p.Asp834His Uncertain significance Single submitter
- PRKD3 p.Glu362Val Uncertain significance Single submitter
- PRKD3 p.Glu487Gly Uncertain significance Single submitter
- PRKD3 p.Glu617Gln Uncertain significance Single submitter
- PRKD3 p.Glu850Asp Uncertain significance Single submitter
- PRKD3 p.Gly43Arg Uncertain significance Single submitter
- PRKD3 p.Gly545Glu Uncertain significance Single submitter
- PRKD3 p.His277Gln Uncertain significance Single submitter
- PRKD3 p.His550Gln Uncertain significance Single submitter
- PRKD3 p.His632Leu Uncertain significance Single submitter
- PRKD3 p.Ile340Thr Uncertain significance Single submitter
- PRKD3 p.Ile390Val Uncertain significance Single submitter
- PRKD3 p.Ile848Val Uncertain significance Single submitter
- PRKD3 p.Ile853Val Uncertain significance Single submitter
- PRKD3 p.Ile878Thr Uncertain significance Single submitter
- PRKD3 p.Leu15Phe Uncertain significance Single submitter
- PRKD3 p.Leu510Phe Uncertain significance Single submitter
- PRKD3 p.Lys411Asn Uncertain significance Single submitter
- PRKD3 p.Lys825Arg Uncertain significance Single submitter
- PRKD3 p.Met263Ile Uncertain significance Single submitter
- PRKD3 p.Met370Ile Uncertain significance Single submitter
- PRKD3 p.Met886Lys Uncertain significance Single submitter
- PRKD3 p.Phe371Leu Uncertain significance Single submitter
- PRKD3 p.Pro16Thr Uncertain significance Single submitter
- PRKD3 p.Pro201Leu Uncertain significance Single submitter
- PRKD3 p.Pro225Arg Uncertain significance Single submitter
- PRKD3 p.Pro227Leu Uncertain significance Single submitter
- PRKD3 p.Pro341Thr Uncertain significance Single submitter
- PRKD3 p.Ser118Ala Uncertain significance Single submitter
- PRKD3 p.Ser31Gly Uncertain significance Single submitter
- PRKD3 p.Ser376Cys Uncertain significance Single submitter
- PRKD3 p.Ser61Thr Uncertain significance Single submitter
- PRKD3 p.Thr166Ala Uncertain significance Single submitter
- PRKD3 p.Thr34Ala Uncertain significance Single submitter
- PRKD3 p.Thr34Met Uncertain significance Single submitter
- PRKD3 p.Thr427Ala Uncertain significance Single submitter
- PRKD3 p.Thr59Arg Uncertain significance Single submitter
- PRKD3 p.Trp422Arg Uncertain significance Single submitter
- PRKD3 p.Val22Ala Uncertain significance Single submitter
- PRKD3 p.Val497Phe Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- PRKD3 p.Ala530Gly Uncertain significance Single submitter
- PRKD3 p.Arg211His Uncertain significance Single submitter
- PRKD3 p.Arg670Gln Uncertain significance Single submitter
- PRKD3 p.Arg674Gln Uncertain significance Single submitter
- PRKD3 p.Arg847Gly Uncertain significance Single submitter
- PRKD3 p.Arg847His Uncertain significance Single submitter
- PRKD3 p.Cys100Gly Uncertain significance Single submitter
- PRKD3 p.Gln151His Uncertain significance Single submitter
- PRKD3 p.Gly104Asp Uncertain significance Single submitter
- PRKD3 p.Gly453Glu Uncertain significance Single submitter
- PRKD3 p.Ile75Thr Uncertain significance Single submitter
- PRKD3 p.Lys199Arg Uncertain significance Single submitter
- PRKD3 p.Lys816Asn Uncertain significance Single submitter
- PRKD3 p.Met105Lys Uncertain significance Single submitter
- PRKD3 p.Phe327Leu Uncertain significance Single submitter
- PRKD3 p.Phe486Leu Uncertain significance Single submitter
- PRKD3 p.Ser205Asn Uncertain significance Single submitter
- PRKD3 p.Tyr873Cys Uncertain significance Single submitter
- PRKD3 p.Tyr873His Uncertain significance Single submitter
- PRKD3 p.Val207Gly Uncertain significance Single submitter
- PRKD3 p.Val762Leu Uncertain significance Single submitter
All PRKD3 variants
Likely benign 2
- p.Asn346Ser Single submitter
- p.Ile468Val Single submitter
Uncertain significance 88
- p.Asn882Lys Multiple submitters ⚠
- p.Ala3Ser Single submitter ⚠
- p.Ala511Gly Single submitter ⚠
- p.Ala530Gly Single submitter ⚠
- p.Arg211His Single submitter ⚠
- p.Arg211Leu Single submitter ⚠
- p.Arg297Cys Single submitter ⚠
- p.Arg355Gln Single submitter ⚠
- p.Arg429Met Single submitter
- p.Arg433Ser Single submitter ⚠
- p.Arg467His Single submitter ⚠
- p.Arg528Cys Single submitter ⚠
- p.Arg670Gln Single submitter ⚠
- p.Arg674Gln Single submitter ⚠
- p.Arg725Cys Single submitter ⚠
- p.Arg725Gly Single submitter ⚠
- p.Arg749Trp Single submitter ⚠
- p.Arg755His Single submitter ⚠
- p.Arg847Gly Single submitter ⚠
- p.Arg847His Single submitter ⚠
- p.Asn120Asp Single submitter ⚠
- p.Asn328Ser Single submitter ⚠
- p.Asn482Ser Single submitter ⚠
- p.Asn754Thr Single submitter ⚠
- p.Asn882His Single submitter ⚠
- p.Asp352Gly Single submitter ⚠
- p.Asp368Val Single submitter ⚠
- p.Asp379Asn Single submitter ⚠
- p.Asp441His Single submitter ⚠
- p.Asp834His Single submitter ⚠
- p.Cys100Gly Single submitter ⚠
- p.Cys485Ser Single submitter
- p.Gln151His Single submitter ⚠
- p.Glu362Val Single submitter ⚠
- p.Glu487Gly Single submitter ⚠
- p.Glu617Gln Single submitter ⚠
- p.Glu850Asp Single submitter ⚠
- p.Gly104Asp Single submitter ⚠
- p.Gly43Arg Single submitter ⚠
- p.Gly453Glu Single submitter ⚠
- p.Gly545Glu Single submitter ⚠
- p.His277Gln Single submitter ⚠
- p.His550Gln Single submitter ⚠
- p.His632Leu Single submitter ⚠
- p.Ile340Thr Single submitter ⚠
- p.Ile390Val Single submitter ⚠
- p.Ile75Thr Single submitter ⚠
- p.Ile848Val Single submitter ⚠
- p.Ile853Val Single submitter ⚠
- p.Ile878Thr Single submitter ⚠
- p.Leu15Phe Single submitter ⚠
- p.Leu510Phe Single submitter ⚠
- p.Lys199Arg Single submitter ⚠
- p.Lys209fs Single submitter
- p.Lys411Asn Single submitter ⚠
- p.Lys816Asn Single submitter ⚠
- p.Lys825Arg Single submitter ⚠
- p.Met105Lys Single submitter ⚠
- p.Met263Ile Single submitter ⚠
- p.Met370Ile Single submitter ⚠
- p.Met886Lys Single submitter ⚠
- p.Phe327Leu Single submitter ⚠
- p.Phe371Leu Single submitter ⚠
- p.Phe486Leu Single submitter ⚠
- p.Pro16Thr Single submitter ⚠
- p.Pro201Leu Single submitter ⚠
- p.Pro225Arg Single submitter ⚠
- p.Pro227Leu Single submitter ⚠
- p.Pro341Thr Single submitter ⚠
- p.Ser118Ala Single submitter ⚠
- p.Ser142Ala Single submitter
- p.Ser205Asn Single submitter ⚠
- p.Ser31Gly Single submitter ⚠
- p.Ser376Cys Single submitter ⚠
- p.Ser61Thr Single submitter ⚠
- p.Thr166Ala Single submitter ⚠
- p.Thr34Ala Single submitter ⚠
- p.Thr34Met Single submitter ⚠
- p.Thr427Ala Single submitter ⚠
- p.Thr59Arg Single submitter ⚠
- p.Trp253Leu Single submitter
- p.Trp422Arg Single submitter ⚠
- p.Tyr873Cys Single submitter ⚠
- p.Tyr873His Single submitter ⚠
- p.Val207Gly Single submitter ⚠
- p.Val22Ala Single submitter ⚠
- p.Val497Phe Single submitter ⚠
- p.Val762Leu Single submitter ⚠