PRLR — 86 ClinVar variants
All ClinVar germline PRLR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
3 Pathogenic · 1 Likely pathogenic · 1 Conflicting · 3 Benign · 12 Likely benign · 66 Uncertain significance
Full PRLR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
PRLR p.Ile170Leu
Conflicting
No assertion criteria
PRLR-related disorder
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRLR p.Glu485Ala Uncertain significance Multiple submitters
-
PRLR p.Ile79Val
Uncertain significance
Multiple submitters
familial hyperprolactinemia
-
PRLR p.Thr490Met
Uncertain significance
Multiple submitters
multiple fibroadenoma of the breast
- PRLR p.Ala185Ser Uncertain significance Single submitter
- PRLR p.Ala221Val Uncertain significance Single submitter
-
PRLR p.Ala281Val
Uncertain significance
Single submitter
familial hyperprolactinemia
- PRLR p.Ala295Val Uncertain significance Single submitter
- PRLR p.Ala446Thr Uncertain significance Single submitter
- PRLR p.Ala579Thr Uncertain significance Single submitter
-
PRLR p.Asn40Ser
Uncertain significance
Single submitter
multiple fibroadenoma of the breast
- PRLR p.Asp280Ala Uncertain significance Single submitter
- PRLR p.Asp300Tyr Uncertain significance Single submitter
- PRLR p.Asp610Tyr Uncertain significance Single submitter
- PRLR p.Cys364Tyr Uncertain significance Single submitter
- PRLR p.Gln108His Uncertain significance Single submitter
- PRLR p.Gln527His Uncertain significance Single submitter
- PRLR p.Glu378Asp Uncertain significance Single submitter
- PRLR p.Glu400Gly Uncertain significance Single submitter
- PRLR p.Glu469Lys Uncertain significance Single submitter
- PRLR p.Glu541Asp Uncertain significance Single submitter
- PRLR p.Gly442Ser Uncertain significance Single submitter
- PRLR p.Gly502Asp Uncertain significance Single submitter
- PRLR p.Gly51Glu Uncertain significance Single submitter
- PRLR p.His390Asp Uncertain significance Single submitter
- PRLR p.His622Arg Uncertain significance Single submitter
- PRLR p.Ile182Asn Uncertain significance Single submitter
- PRLR p.Ile251Leu Uncertain significance Single submitter
- PRLR p.Ile251Thr Uncertain significance Single submitter
- PRLR p.Leu156Val Uncertain significance Single submitter
- PRLR p.Leu196Val Uncertain significance Single submitter
- PRLR p.Leu203His Uncertain significance Single submitter
- PRLR p.Lys277Arg Uncertain significance Single submitter
- PRLR p.Lys382Met Uncertain significance Single submitter
- PRLR p.Lys466Met Uncertain significance Single submitter
- PRLR p.Lys505Glu Uncertain significance Single submitter
- PRLR p.Lys567Glu Uncertain significance Single submitter
- PRLR p.Met232Val Uncertain significance Single submitter
- PRLR p.Met399Thr Uncertain significance Single submitter
- PRLR p.Pro145Arg Uncertain significance Single submitter
- PRLR p.Pro404Ala Uncertain significance Single submitter
- PRLR p.Pro421Leu Uncertain significance Single submitter
- PRLR p.Pro443Leu Uncertain significance Single submitter
-
PRLR p.Pro495Ser
Uncertain significance
Single submitter
familial hyperprolactinemia
- PRLR p.Pro525Gln Uncertain significance Single submitter
- PRLR p.Ser114Leu Uncertain significance Single submitter
- PRLR p.Ser335Arg Uncertain significance Single submitter
- PRLR p.Thr19Asn Uncertain significance Single submitter
- PRLR p.Thr389Ala Uncertain significance Single submitter
- PRLR p.Thr539Ser Uncertain significance Single submitter
- PRLR p.Thr9Ser Uncertain significance Single submitter
- PRLR p.Tyr314His Uncertain significance Single submitter
- PRLR p.Val237Met Uncertain significance Single submitter
- PRLR p.Val256Ala Uncertain significance Single submitter
- PRLR p.Val256Met Uncertain significance Single submitter
- PRLR p.Val264Met Uncertain significance Single submitter
- PRLR p.Val479Ile Uncertain significance Single submitter
- PRLR p.Val552Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- PRLR p.Arg37His Uncertain significance Single submitter
- PRLR p.Asp518Gly Uncertain significance Single submitter
- PRLR p.Gln126His Uncertain significance Single submitter
-
PRLR p.Leu284Trp
Likely pathogenic
Single submitter
primary ovarian failure
- PRLR p.Met95Thr Uncertain significance Single submitter
- PRLR p.Pro153Leu Uncertain significance Single submitter
- PRLR p.Pro39Leu Uncertain significance Single submitter
-
PRLR p.Glu175Lys
Likely benign
No assertion criteria
PRLR-related disorder
-
PRLR p.His212Arg
Pathogenic
No assertion criteria
familial hyperprolactinemia
All PRLR variants
Pathogenic 3
- p.Arg171Ter No assertion criteria familial hyperprolactinemia
- p.His212Arg No assertion criteria familial hyperprolactinemia ⚠
- p.Pro269Leu No assertion criteria familial hyperprolactinemia
Likely pathogenic 1
- p.Leu284Trp Single submitter primary ovarian failure ⚠
Conflicting classifications of pathogenicity 1
- p.Ile170Leu No assertion criteria PRLR-related disorder ⚠
Benign 3
- c.685+7G>A Multiple submitters
- p.Glu470= Multiple submitters
- p.Asn568= Single submitter
Likely benign 12
- p.Arg66Lys Single submitter
- p.Asn432Ser Single submitter
- p.Gly445Asp Single submitter
- p.Gly532= Single submitter
- p.Gly538Arg Single submitter
- p.Gly551Arg Single submitter
- p.Leu26= Single submitter
- p.Pro220= Single submitter
- p.Pro447= Single submitter
- p.Asn385= No assertion criteria PRLR-related disorder
- p.Glu175Lys No assertion criteria PRLR-related disorder ⚠
- p.Gly362= No assertion criteria PRLR-related disorder
Uncertain significance 66
- p.Glu485Ala Multiple submitters ⚠
- p.Ile79Val Multiple submitters familial hyperprolactinemia ⚠
- p.Thr490Met Multiple submitters multiple fibroadenoma of the breast ⚠
- p.Ala185Ser Single submitter ⚠
- p.Ala221Val Single submitter ⚠
- p.Ala281Val Single submitter familial hyperprolactinemia ⚠
- p.Ala295Val Single submitter ⚠
- p.Ala446Thr Single submitter ⚠
- p.Ala579Thr Single submitter ⚠
- p.Arg207Cys Single submitter
- p.Arg37His Single submitter ⚠
- p.Asn40Ser Single submitter multiple fibroadenoma of the breast ⚠
- p.Asp280Ala Single submitter ⚠
- p.Asp300Tyr Single submitter ⚠
- p.Asp518Gly Single submitter ⚠
- p.Asp610Tyr Single submitter ⚠
- p.Cys364Tyr Single submitter ⚠
- p.Gln108His Single submitter ⚠
- p.Gln126His Single submitter ⚠
- p.Gln527His Single submitter ⚠
- p.Glu378Asp Single submitter ⚠
- p.Glu400Gly Single submitter ⚠
- p.Glu469Lys Single submitter ⚠
- p.Glu541Asp Single submitter ⚠
- p.Gly442Ser Single submitter ⚠
- p.Gly502Asp Single submitter ⚠
- p.Gly51Glu Single submitter ⚠
- p.His390Asp Single submitter ⚠
- p.His622Arg Single submitter ⚠
- p.Ile182Asn Single submitter ⚠
- p.Ile251Leu Single submitter ⚠
- p.Ile251Thr Single submitter ⚠
- p.Leu156Val Single submitter ⚠
- p.Leu196Val Single submitter ⚠
- p.Leu203His Single submitter ⚠
- p.Lys277Arg Single submitter ⚠
- p.Lys382Met Single submitter ⚠
- p.Lys466Met Single submitter ⚠
- p.Lys505Glu Single submitter ⚠
- p.Lys567Glu Single submitter ⚠
- p.Met232Val Single submitter ⚠
- p.Met399Thr Single submitter ⚠
- p.Met95Thr Single submitter ⚠
- p.Pro145Arg Single submitter ⚠
- p.Pro153Leu Single submitter ⚠
- p.Pro39Leu Single submitter ⚠
- p.Pro404Ala Single submitter ⚠
- p.Pro421Leu Single submitter ⚠
- p.Pro443Leu Single submitter ⚠
- p.Pro495Ser Single submitter familial hyperprolactinemia ⚠
- p.Pro525Gln Single submitter ⚠
- p.Ser114Leu Single submitter ⚠
- p.Ser335Arg Single submitter ⚠
- p.Thr19Asn Single submitter ⚠
- p.Thr389Ala Single submitter ⚠
- p.Thr539Ser Single submitter ⚠
- p.Thr9Ser Single submitter ⚠
- p.Tyr314His Single submitter ⚠
- p.Val237Met Single submitter ⚠
- p.Val256Ala Single submitter ⚠
- p.Val256Met Single submitter ⚠
- p.Val264Met Single submitter ⚠
- p.Val479Ile Single submitter ⚠
- p.Val552Leu Single submitter ⚠
- c.373+637_373+688del No assertion criteria schizophrenia
- c.374-1769_374-1768insATATATATATATATTATATATATATCTATATATTATAT No assertion criteria schizophrenia