PSMB5 — 31 ClinVar variants
All ClinVar germline PSMB5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
1 Likely benign · 30 Uncertain significance
Full PSMB5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PSMB5 p.Ala74Ser Uncertain significance Single submitter
- PSMB5 p.Arg132Cys Uncertain significance Single submitter
- PSMB5 p.Arg132Pro Uncertain significance Single submitter
- PSMB5 p.Arg132Ser Uncertain significance Single submitter
- PSMB5 p.Arg245Gln Uncertain significance Single submitter
- PSMB5 p.Asp199Gly Uncertain significance Single submitter
- PSMB5 p.Gly201Val Uncertain significance Single submitter
- PSMB5 p.Ile133Ser Uncertain significance Single submitter
- PSMB5 p.Ile72Val Uncertain significance Single submitter
- PSMB5 p.Lys92Glu Uncertain significance Single submitter
- PSMB5 p.Phe185Leu Uncertain significance Single submitter
- PSMB5 p.Phe67Leu Uncertain significance Single submitter
- PSMB5 p.Thr103Ser Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- PSMB5 p.Ala119Gly Uncertain significance Single submitter
- PSMB5 p.Arg120Gln Uncertain significance Single submitter
- PSMB5 p.Arg216His Uncertain significance Single submitter
- PSMB5 p.Arg239Gln Uncertain significance Single submitter
- PSMB5 p.Arg239Trp Uncertain significance Single submitter
- PSMB5 p.Arg68Gly Uncertain significance Single submitter
- PSMB5 p.Arg68His Uncertain significance Single submitter
- PSMB5 p.Asn234Ser Uncertain significance Single submitter
- PSMB5 p.Asp253Asn Uncertain significance Single submitter
- PSMB5 p.His69Arg Uncertain significance Single submitter
- PSMB5 p.Leu27Val Uncertain significance Single submitter
- PSMB5 p.Lys165Glu Uncertain significance Single submitter
- PSMB5 p.Met152Leu Uncertain significance Single submitter
- PSMB5 p.Ser261Cys Uncertain significance Single submitter
- PSMB5 p.Thr158Ile Uncertain significance Single submitter
- PSMB5 p.Tyr220Cys Uncertain significance Single submitter
- PSMB5 p.Val197Ile Uncertain significance Single submitter
All PSMB5 variants
Likely benign 1
- p.Tyr172= Single submitter
Uncertain significance 30
- p.Ala119Gly Single submitter ⚠
- p.Ala74Ser Single submitter ⚠
- p.Arg120Gln Single submitter ⚠
- p.Arg132Cys Single submitter ⚠
- p.Arg132Pro Single submitter ⚠
- p.Arg132Ser Single submitter ⚠
- p.Arg216His Single submitter ⚠
- p.Arg239Gln Single submitter ⚠
- p.Arg239Trp Single submitter ⚠
- p.Arg245Gln Single submitter ⚠
- p.Arg68Gly Single submitter ⚠
- p.Arg68His Single submitter ⚠
- p.Asn234Ser Single submitter ⚠
- p.Asp199Gly Single submitter ⚠
- p.Asp253Asn Single submitter ⚠
- p.Gly201Val Single submitter ⚠
- p.His69Arg Single submitter ⚠
- p.Ile133Ser Single submitter ⚠
- p.Ile72Val Single submitter ⚠
- p.Leu27Val Single submitter ⚠
- p.Lys165Glu Single submitter ⚠
- p.Lys92Glu Single submitter ⚠
- p.Met152Leu Single submitter ⚠
- p.Phe185Leu Single submitter ⚠
- p.Phe67Leu Single submitter ⚠
- p.Ser261Cys Single submitter ⚠
- p.Thr103Ser Single submitter ⚠
- p.Thr158Ile Single submitter ⚠
- p.Tyr220Cys Single submitter ⚠
- p.Val197Ile Single submitter ⚠