PTPRA — 81 ClinVar variants
All ClinVar germline PTPRA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
1 Benign · 2 Likely benign · 78 Uncertain significance
Full PTPRA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PTPRA p.Ala128Thr Uncertain significance Single submitter
- PTPRA p.Ala154Val Uncertain significance Single submitter
- PTPRA p.Ala40Val Uncertain significance Single submitter
- PTPRA p.Ala437Ser Uncertain significance Single submitter
- PTPRA p.Ala754Thr Uncertain significance Single submitter
- PTPRA p.Arg366Trp Uncertain significance Single submitter
- PTPRA p.Arg690Trp Uncertain significance Single submitter
- PTPRA p.Arg738Gly Uncertain significance Single submitter
- PTPRA p.Asn124Ser Uncertain significance Single submitter
- PTPRA p.Asn188Ser Uncertain significance Single submitter
- PTPRA p.Asn297Ser Uncertain significance Single submitter
- PTPRA p.Asn393Lys Uncertain significance Single submitter
- PTPRA p.Asn51Ser Uncertain significance Single submitter
- PTPRA p.Asn530Ser Uncertain significance Single submitter
- PTPRA p.Asn80Ser Uncertain significance Single submitter
- PTPRA p.Asn86Ser Uncertain significance Single submitter
- PTPRA p.Asp110Gly Uncertain significance Single submitter
- PTPRA p.Asp199Gly Uncertain significance Single submitter
- PTPRA p.Asp2Val Uncertain significance Single submitter
- PTPRA p.Asp390Asn Uncertain significance Single submitter
- PTPRA p.Asp488Asn Uncertain significance Single submitter
- PTPRA p.Asp506Gly Uncertain significance Single submitter
- PTPRA p.Asp675Tyr Uncertain significance Single submitter
- PTPRA p.Cys348Ser Uncertain significance Single submitter
- PTPRA p.Cys668Tyr Uncertain significance Single submitter
- PTPRA p.Glu122Lys Uncertain significance Single submitter
- PTPRA p.Glu267Gly Uncertain significance Single submitter
- PTPRA p.Glu41Lys Uncertain significance Single submitter
- PTPRA p.Glu665Lys Uncertain significance Single submitter
- PTPRA p.Glu667Gln Uncertain significance Single submitter
- PTPRA p.Glu669Asp Uncertain significance Single submitter
- PTPRA p.Gly11Val Uncertain significance Single submitter
- PTPRA p.Gly195Ser Uncertain significance Single submitter
- PTPRA p.Gly708Ser Uncertain significance Single submitter
- PTPRA p.Gly87Ala Uncertain significance Single submitter
- PTPRA p.His726Gln Uncertain significance Single submitter
- PTPRA p.Ile101Met Uncertain significance Single submitter
- PTPRA p.Ile152Val Uncertain significance Single submitter
- PTPRA p.Ile710Ser Uncertain significance Single submitter
- PTPRA p.Lys786Arg Uncertain significance Single submitter
- PTPRA p.Pro120Thr Uncertain significance Single submitter
- PTPRA p.Pro136Leu Uncertain significance Single submitter
- PTPRA p.Ser204Asn Uncertain significance Single submitter
- PTPRA p.Ser293Cys Uncertain significance Single submitter
- PTPRA p.Ser746Arg Uncertain significance Single submitter
- PTPRA p.Thr681Asn Uncertain significance Single submitter
- PTPRA p.Thr78Ser Uncertain significance Single submitter
- PTPRA p.Tyr522His Uncertain significance Single submitter
- PTPRA p.Val166Met Uncertain significance Single submitter
- PTPRA p.Val380Ile Uncertain significance Single submitter
- PTPRA p.Val427Met Uncertain significance Single submitter
- PTPRA p.Val470Leu Uncertain significance Single submitter
- PTPRA p.Val678Ala Uncertain significance Single submitter
- PTPRA p.Val716Met Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- PTPRA p.Ala351Thr Uncertain significance Single submitter
- PTPRA p.Ala714Thr Uncertain significance Single submitter
- PTPRA p.Ala734Thr Uncertain significance Single submitter
- PTPRA p.Arg191His Uncertain significance Single submitter
- PTPRA p.Arg690Gln Uncertain significance Single submitter
- PTPRA p.Asn554Ser Uncertain significance Single submitter
- PTPRA p.Cys430Ser Uncertain significance Single submitter
- PTPRA p.Gln546His Uncertain significance Single submitter
- PTPRA p.Gly527Glu Uncertain significance Single submitter
- PTPRA p.His501Gln Uncertain significance Single submitter
- PTPRA p.Ile728Val Uncertain significance Single submitter
- PTPRA p.Leu7Pro Uncertain significance Single submitter
- PTPRA p.Met234Ile Uncertain significance Single submitter
- PTPRA p.Pro286Leu Uncertain significance Single submitter
- PTPRA p.Ser649Cys Uncertain significance Single submitter
- PTPRA p.Thr106Met Uncertain significance Single submitter
- PTPRA p.Thr23Ala Uncertain significance Single submitter
- PTPRA p.Thr32Lys Uncertain significance Single submitter
- PTPRA p.Thr94Ile Uncertain significance Single submitter
- PTPRA p.Val157Ala Uncertain significance Single submitter
- PTPRA p.Val205Met Uncertain significance Single submitter
- PTPRA p.Val223Leu Uncertain significance Single submitter
- PTPRA p.Val223Met Uncertain significance Single submitter
- PTPRA p.Val748Ile Uncertain significance Single submitter
All PTPRA variants
Benign 1
- p.Ala154= Multiple submitters
Likely benign 2
- p.Cys16Arg Single submitter
- p.Ser102Leu Single submitter
Uncertain significance 78
- p.Ala128Thr Single submitter ⚠
- p.Ala154Val Single submitter ⚠
- p.Ala351Thr Single submitter ⚠
- p.Ala40Val Single submitter ⚠
- p.Ala437Ser Single submitter ⚠
- p.Ala714Thr Single submitter ⚠
- p.Ala734Thr Single submitter ⚠
- p.Ala754Thr Single submitter ⚠
- p.Arg191His Single submitter ⚠
- p.Arg366Trp Single submitter ⚠
- p.Arg690Gln Single submitter ⚠
- p.Arg690Trp Single submitter ⚠
- p.Arg738Gly Single submitter ⚠
- p.Asn124Ser Single submitter ⚠
- p.Asn188Ser Single submitter ⚠
- p.Asn297Ser Single submitter ⚠
- p.Asn393Lys Single submitter ⚠
- p.Asn51Ser Single submitter ⚠
- p.Asn530Ser Single submitter ⚠
- p.Asn554Ser Single submitter ⚠
- p.Asn80Ser Single submitter ⚠
- p.Asn86Ser Single submitter ⚠
- p.Asp110Gly Single submitter ⚠
- p.Asp199Gly Single submitter ⚠
- p.Asp2Val Single submitter ⚠
- p.Asp390Asn Single submitter ⚠
- p.Asp488Asn Single submitter ⚠
- p.Asp506Gly Single submitter ⚠
- p.Asp675Tyr Single submitter ⚠
- p.Cys348Ser Single submitter ⚠
- p.Cys430Ser Single submitter ⚠
- p.Cys668Tyr Single submitter ⚠
- p.Gln546His Single submitter ⚠
- p.Glu122Lys Single submitter ⚠
- p.Glu267Gly Single submitter ⚠
- p.Glu41Lys Single submitter ⚠
- p.Glu665Lys Single submitter ⚠
- p.Glu667Gln Single submitter ⚠
- p.Glu669Asp Single submitter ⚠
- p.Gly11Val Single submitter ⚠
- p.Gly195Ser Single submitter ⚠
- p.Gly527Glu Single submitter ⚠
- p.Gly708Ser Single submitter ⚠
- p.Gly87Ala Single submitter ⚠
- p.His501Gln Single submitter ⚠
- p.His726Gln Single submitter ⚠
- p.Ile101Met Single submitter ⚠
- p.Ile152Val Single submitter ⚠
- p.Ile710Ser Single submitter ⚠
- p.Ile728Val Single submitter ⚠
- p.Leu7Pro Single submitter ⚠
- p.Lys786Arg Single submitter ⚠
- p.Met234Ile Single submitter ⚠
- p.Pro120Thr Single submitter ⚠
- p.Pro136Leu Single submitter ⚠
- p.Pro286Leu Single submitter ⚠
- p.Ser204Asn Single submitter ⚠
- p.Ser293Cys Single submitter ⚠
- p.Ser649Cys Single submitter ⚠
- p.Ser746Arg Single submitter ⚠
- p.Thr106Met Single submitter ⚠
- p.Thr23Ala Single submitter ⚠
- p.Thr32Lys Single submitter ⚠
- p.Thr681Asn Single submitter ⚠
- p.Thr78Ser Single submitter ⚠
- p.Thr94Ile Single submitter ⚠
- p.Tyr522His Single submitter ⚠
- p.Val157Ala Single submitter ⚠
- p.Val166Met Single submitter ⚠
- p.Val205Met Single submitter ⚠
- p.Val223Leu Single submitter ⚠
- p.Val223Met Single submitter ⚠
- p.Val380Ile Single submitter ⚠
- p.Val427Met Single submitter ⚠
- p.Val470Leu Single submitter ⚠
- p.Val678Ala Single submitter ⚠
- p.Val716Met Single submitter ⚠
- p.Val748Ile Single submitter ⚠