Sugi Variant

Sugi Variant/PTPRJ

PTPRJ — 215 ClinVar variants

All ClinVar germline PTPRJ variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 161 flagged for review →

3 Pathogenic · 2 Conflicting · 8 Benign · 41 Likely benign · 161 Uncertain significance

Full PTPRJ gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 161

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 127

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 31

The independent predictors disagree with each other — read with care.

All PTPRJ variants

Pathogenic 3

Conflicting classifications of pathogenicity 2

Benign 8

Likely benign 41

Uncertain significance 161