PYM1 — 9 ClinVar variants
All ClinVar germline PYM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
9 Uncertain significance
Full PYM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PYM1 p.Ala9Thr Uncertain significance Single submitter
- PYM1 p.Arg111Thr Uncertain significance Single submitter
- PYM1 p.Arg132Gln Uncertain significance Single submitter
- PYM1 p.Glu77Gly Uncertain significance Single submitter
- PYM1 p.Gly24Arg Uncertain significance Single submitter
- PYM1 p.Pro57Leu Uncertain significance Single submitter
- PYM1 p.Pro70Ser Uncertain significance Single submitter
- PYM1 p.Pro73Leu Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All PYM1 variants
Uncertain significance 9
- p.Ala9Thr Single submitter ⚠
- p.Arg111Thr Single submitter ⚠
- p.Arg132Gln Single submitter ⚠
- p.Glu77Gly Single submitter ⚠
- p.Gly24Arg Single submitter ⚠
- p.Pro57Leu Single submitter ⚠
- p.Pro70Ser Single submitter ⚠
- p.Pro73Leu Single submitter ⚠
- p.Ser139Phe Single submitter ⚠