QTRT1 — 79 ClinVar variants
All ClinVar germline QTRT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
3 Benign · 3 Likely benign · 73 Uncertain significance
Full QTRT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- QTRT1 p.Ala244Val Uncertain significance Single submitter
- QTRT1 p.Ala359Thr Uncertain significance Single submitter
- QTRT1 p.Ala64Gly Uncertain significance Single submitter
- QTRT1 p.Arg128Pro Uncertain significance Single submitter
- QTRT1 p.Arg180His Uncertain significance Single submitter
- QTRT1 p.Arg184Gln Uncertain significance Single submitter
- QTRT1 p.Arg184Trp Uncertain significance Single submitter
- QTRT1 p.Arg18Gln Uncertain significance Single submitter
- QTRT1 p.Arg210Trp Uncertain significance Single submitter
- QTRT1 p.Arg249Trp Uncertain significance Single submitter
- QTRT1 p.Arg25Leu Uncertain significance Single submitter
- QTRT1 p.Arg285Gln Uncertain significance Single submitter
- QTRT1 p.Arg285Trp Uncertain significance Single submitter
- QTRT1 p.Arg288Cys Uncertain significance Single submitter
- QTRT1 p.Arg361Cys Uncertain significance Single submitter
- QTRT1 p.Arg361His Uncertain significance Single submitter
- QTRT1 p.Arg68Pro Uncertain significance Single submitter
- QTRT1 p.Arg80Lys Uncertain significance Single submitter
- QTRT1 p.Asn90Ser Uncertain significance Single submitter
- QTRT1 p.Gln61Glu Uncertain significance Single submitter
- QTRT1 p.Glu60Lys Uncertain significance Single submitter
- QTRT1 p.Gly107Val Uncertain significance Single submitter
- QTRT1 p.Gly228Arg Uncertain significance Single submitter
- QTRT1 p.Gly232Arg Uncertain significance Single submitter
- QTRT1 p.Gly31Ser Uncertain significance Single submitter
- QTRT1 p.Gly382Arg Uncertain significance Single submitter
- QTRT1 p.Gly3Arg Uncertain significance Single submitter
- QTRT1 p.Gly403Asp Uncertain significance Single submitter
- QTRT1 p.Leu137Val Uncertain significance Single submitter
- QTRT1 p.Leu62Arg Uncertain significance Single submitter
- QTRT1 p.Lys142Gln Uncertain significance Single submitter
- QTRT1 p.Met175Thr Uncertain significance Single submitter
- QTRT1 p.Met357Val Uncertain significance Single submitter
- QTRT1 p.Met380Thr Uncertain significance Single submitter
- QTRT1 p.Pro130Leu Uncertain significance Single submitter
- QTRT1 p.Pro251Leu Uncertain significance Single submitter
- QTRT1 p.Pro315Leu Uncertain significance Single submitter
- QTRT1 p.Pro384Ser Uncertain significance Single submitter
- QTRT1 p.Pro99Ser Uncertain significance Single submitter
- QTRT1 p.Ser237Leu Uncertain significance Single submitter
- QTRT1 p.Ser358Arg Uncertain significance Single submitter
- QTRT1 p.Thr104Met Uncertain significance Single submitter
- QTRT1 p.Thr218Ser Uncertain significance Single submitter
- QTRT1 p.Thr318Pro Uncertain significance Single submitter
- QTRT1 p.Thr385Ser Uncertain significance Single submitter
- QTRT1 p.Val161Met Uncertain significance Single submitter
- QTRT1 p.Val261Ala Uncertain significance Single submitter
- QTRT1 p.Val271Met Uncertain significance Single submitter
- QTRT1 p.Val281Ile Uncertain significance Single submitter
- QTRT1 p.Val365Met Uncertain significance Single submitter
- QTRT1 p.Val398Leu Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- QTRT1 p.Ala199Thr Uncertain significance Single submitter
- QTRT1 p.Ala199Val Uncertain significance Single submitter
- QTRT1 p.Ala21Val Uncertain significance Single submitter
- QTRT1 p.Arg126Gly Uncertain significance Single submitter
- QTRT1 p.Arg170Cys Uncertain significance Single submitter
- QTRT1 p.Arg18Gly Uncertain significance Single submitter
- QTRT1 p.Arg18Trp Uncertain significance Single submitter
- QTRT1 p.Asp206His Uncertain significance Single submitter
- QTRT1 p.Gly91Asp Uncertain significance Single submitter
- QTRT1 p.Met357Thr Uncertain significance Single submitter
- QTRT1 p.Pro192Ser Uncertain significance Single submitter
- QTRT1 p.Ser248Cys Uncertain significance Single submitter
- QTRT1 p.Ser248Phe Uncertain significance Single submitter
- QTRT1 p.Thr167Asn Uncertain significance Single submitter
- QTRT1 p.Val373Met Uncertain significance Single submitter
All QTRT1 variants
Benign 3
- c.862-10T>C Multiple submitters
- c.313-4T>G Single submitter
- p.Leu301= Single submitter
Likely benign 3
- p.Ala379Thr Single submitter
- p.Arg191Gln Single submitter
- p.Gln190Arg Single submitter
Uncertain significance 73
- p.Ala199Thr Single submitter ⚠
- p.Ala199Val Single submitter ⚠
- p.Ala21Val Single submitter ⚠
- p.Ala244Val Single submitter ⚠
- p.Ala359Thr Single submitter ⚠
- p.Ala64Gly Single submitter ⚠
- p.Arg126Gly Single submitter ⚠
- p.Arg128Pro Single submitter ⚠
- p.Arg170Cys Single submitter ⚠
- p.Arg170His Single submitter
- p.Arg180His Single submitter ⚠
- p.Arg184Gln Single submitter ⚠
- p.Arg184Trp Single submitter ⚠
- p.Arg18Gln Single submitter ⚠
- p.Arg18Gly Single submitter ⚠
- p.Arg18Trp Single submitter ⚠
- p.Arg210Trp Single submitter ⚠
- p.Arg220Gln Single submitter
- p.Arg249Trp Single submitter ⚠
- p.Arg25Leu Single submitter ⚠
- p.Arg285Gln Single submitter ⚠
- p.Arg285Trp Single submitter ⚠
- p.Arg288Cys Single submitter ⚠
- p.Arg327Cys Single submitter
- p.Arg361Cys Single submitter ⚠
- p.Arg361His Single submitter ⚠
- p.Arg68Pro Single submitter ⚠
- p.Arg80Lys Single submitter ⚠
- p.Asn90Ser Single submitter ⚠
- p.Asp206His Single submitter ⚠
- p.Gln61Glu Single submitter ⚠
- p.Glu141Gln Single submitter
- p.Glu60Lys Single submitter ⚠
- p.Gly107Val Single submitter ⚠
- p.Gly228Arg Single submitter ⚠
- p.Gly232Arg Single submitter ⚠
- p.Gly31Ser Single submitter ⚠
- p.Gly382Arg Single submitter ⚠
- p.Gly3Arg Single submitter ⚠
- p.Gly403Asp Single submitter ⚠
- p.Gly91Asp Single submitter ⚠
- p.Leu137Val Single submitter ⚠
- p.Leu182Val Single submitter
- p.Leu62Arg Single submitter ⚠
- p.Lys142Gln Single submitter ⚠
- p.Met175Thr Single submitter ⚠
- p.Met357Thr Single submitter ⚠
- p.Met357Val Single submitter ⚠
- p.Met380Thr Single submitter ⚠
- p.Pro130Leu Single submitter ⚠
- p.Pro192Ser Single submitter ⚠
- p.Pro251Leu Single submitter ⚠
- p.Pro315Leu Single submitter ⚠
- p.Pro370Leu Single submitter
- p.Pro384Ser Single submitter ⚠
- p.Pro99Ser Single submitter ⚠
- p.Ser237Leu Single submitter ⚠
- p.Ser248Cys Single submitter ⚠
- p.Ser248Phe Single submitter ⚠
- p.Ser358Arg Single submitter ⚠
- p.Thr104Met Single submitter ⚠
- p.Thr167Asn Single submitter ⚠
- p.Thr218Ser Single submitter ⚠
- p.Thr318Pro Single submitter ⚠
- p.Thr385Ser Single submitter ⚠
- p.Trp181_Cys185del Single submitter
- p.Val161Met Single submitter ⚠
- p.Val261Ala Single submitter ⚠
- p.Val271Met Single submitter ⚠
- p.Val281Ile Single submitter ⚠
- p.Val365Met Single submitter ⚠
- p.Val373Met Single submitter ⚠
- p.Val398Leu Single submitter ⚠