RAMP1 — 35 ClinVar variants
All ClinVar germline RAMP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
2 Benign · 6 Likely benign · 27 Uncertain significance
Full RAMP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RAMP1 p.Ala30Gly Uncertain significance Single submitter
- RAMP1 p.Arg112Trp Uncertain significance Single submitter
- RAMP1 p.Arg37Trp Uncertain significance Single submitter
- RAMP1 p.Arg7Cys Uncertain significance Single submitter
- RAMP1 p.Arg91Ser Uncertain significance Single submitter
- RAMP1 p.Arg99Ser Uncertain significance Single submitter
- RAMP1 p.Asn86Ser Uncertain significance Single submitter
- RAMP1 p.Gln140Leu Uncertain significance Single submitter
- RAMP1 p.Gly116Cys Uncertain significance Single submitter
- RAMP1 p.His19Arg Uncertain significance Single submitter
- RAMP1 p.His20Tyr Uncertain significance Single submitter
- RAMP1 p.Ile63Met Uncertain significance Single submitter
- RAMP1 p.Leu15Val Uncertain significance Single submitter
- RAMP1 p.Leu41Pro Uncertain significance Single submitter
- RAMP1 p.Pro126Thr Uncertain significance Single submitter
- RAMP1 p.Pro9Arg Uncertain significance Single submitter
- RAMP1 p.Thr128Met Uncertain significance Single submitter
- RAMP1 p.Thr54Met Uncertain significance Single submitter
- RAMP1 p.Tyr32Phe Uncertain significance Single submitter
- RAMP1 p.Val124Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- RAMP1 p.Ala77Val Uncertain significance Single submitter
- RAMP1 p.Arg143Cys Uncertain significance Single submitter
- RAMP1 p.Arg143Leu Uncertain significance Single submitter
- RAMP1 p.Cys72Tyr Uncertain significance Single submitter
- RAMP1 p.Gly52Arg Uncertain significance Single submitter
- RAMP1 p.Lys142Glu Uncertain significance Single submitter
All RAMP1 variants
Likely benign 6
- p.Arg67Gly Single submitter
- p.Arg99His Single submitter
- p.Gln43Arg Single submitter
- p.Gly116Ser Single submitter
- p.Ile123Val Single submitter
- p.Val51Ile Single submitter
Uncertain significance 27
- p.Ala30Gly Single submitter ⚠
- p.Ala77Val Single submitter ⚠
- p.Arg112Trp Single submitter ⚠
- p.Arg143Cys Single submitter ⚠
- p.Arg143Leu Single submitter ⚠
- p.Arg37Trp Single submitter ⚠
- p.Arg7Cys Single submitter ⚠
- p.Arg91Ser Single submitter ⚠
- p.Arg99Ser Single submitter ⚠
- p.Asn86Ser Single submitter ⚠
- p.Cys72Tyr Single submitter ⚠
- p.Gln140Leu Single submitter ⚠
- p.Gly116Cys Single submitter ⚠
- p.Gly52Arg Single submitter ⚠
- p.His19Arg Single submitter ⚠
- p.His20Tyr Single submitter ⚠
- p.Ile63Met Single submitter ⚠
- p.Leu15Val Single submitter ⚠
- p.Leu41Pro Single submitter ⚠
- p.Lys142Glu Single submitter ⚠
- p.Pro114Ser Single submitter
- p.Pro126Thr Single submitter ⚠
- p.Pro9Arg Single submitter ⚠
- p.Thr128Met Single submitter ⚠
- p.Thr54Met Single submitter ⚠
- p.Tyr32Phe Single submitter ⚠
- p.Val124Met Single submitter ⚠