RBM22 — 33 ClinVar variants
All ClinVar germline RBM22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Benign · 1 Likely benign · 31 Uncertain significance
Full RBM22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RBM22 p.Ala345Gly Uncertain significance Single submitter
- RBM22 p.Ala99Thr Uncertain significance Single submitter
- RBM22 p.Asn113Asp Uncertain significance Single submitter
- RBM22 p.Glu342Ala Uncertain significance Single submitter
- RBM22 p.Gly415Ala Uncertain significance Single submitter
- RBM22 p.His382Tyr Uncertain significance Single submitter
- RBM22 p.Ile261Thr Uncertain significance Single submitter
- RBM22 p.Ile363Val Uncertain significance Single submitter
- RBM22 p.Lys185Thr Uncertain significance Single submitter
- RBM22 p.Lys212Arg Uncertain significance Single submitter
- RBM22 p.Lys67Met Uncertain significance Single submitter
- RBM22 p.Met107Val Uncertain significance Single submitter
- RBM22 p.Met383Val Uncertain significance Single submitter
- RBM22 p.Met387Val Uncertain significance Single submitter
- RBM22 p.Phe384Val Uncertain significance Single submitter
- RBM22 p.Pro353Leu Uncertain significance Single submitter
- RBM22 p.Pro391Ala Uncertain significance Single submitter
- RBM22 p.Ser126Tyr Uncertain significance Single submitter
- RBM22 p.Ser346Pro Uncertain significance Single submitter
- RBM22 p.Ser355Gly Uncertain significance Single submitter
- RBM22 p.Thr260Met Uncertain significance Single submitter
- RBM22 p.Thr262Ser Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- RBM22 p.Ala279Thr Uncertain significance Single submitter
- RBM22 p.Arg161Gln Uncertain significance Single submitter
- RBM22 p.Arg216Gln Uncertain significance Single submitter
- RBM22 p.Arg62His Uncertain significance Single submitter
- RBM22 p.Gly380Glu Uncertain significance Single submitter
- RBM22 p.His251Gln Uncertain significance Single submitter
- RBM22 p.Lys139Asn Uncertain significance Single submitter
- RBM22 p.Met220Val Uncertain significance Single submitter
- RBM22 p.Pro386Thr Uncertain significance Single submitter
All RBM22 variants
Benign 1
- p.Pro390= Single submitter
Likely benign 1
- c.-8C>T No assertion criteria RBM22-related disorder
Uncertain significance 31
- p.Ala279Thr Single submitter ⚠
- p.Ala345Gly Single submitter ⚠
- p.Ala99Thr Single submitter ⚠
- p.Arg161Gln Single submitter ⚠
- p.Arg216Gln Single submitter ⚠
- p.Arg62His Single submitter ⚠
- p.Asn113Asp Single submitter ⚠
- p.Glu342Ala Single submitter ⚠
- p.Gly380Glu Single submitter ⚠
- p.Gly415Ala Single submitter ⚠
- p.His251Gln Single submitter ⚠
- p.His382Tyr Single submitter ⚠
- p.Ile261Thr Single submitter ⚠
- p.Ile363Val Single submitter ⚠
- p.Lys139Asn Single submitter ⚠
- p.Lys185Thr Single submitter ⚠
- p.Lys212Arg Single submitter ⚠
- p.Lys67Met Single submitter ⚠
- p.Met107Val Single submitter ⚠
- p.Met220Val Single submitter ⚠
- p.Met383Val Single submitter ⚠
- p.Met387Val Single submitter ⚠
- p.Phe384Val Single submitter ⚠
- p.Pro353Leu Single submitter ⚠
- p.Pro386Thr Single submitter ⚠
- p.Pro391Ala Single submitter ⚠
- p.Ser126Tyr Single submitter ⚠
- p.Ser346Pro Single submitter ⚠
- p.Ser355Gly Single submitter ⚠
- p.Thr260Met Single submitter ⚠
- p.Thr262Ser Single submitter ⚠