RBM26 — 98 ClinVar variants

All ClinVar germline RBM26 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →

2 Benign · 4 Likely benign · 92 Uncertain significance

Full RBM26 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 83

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 59

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 24

The independent predictors disagree with each other — read with care.

All RBM26 variants

Benign 2

c.328-7T>A Multiple submitters
p.Asn517Ser Multiple submitters

Likely benign 4

p.Glu971Gln Multiple submitters
p.Ala845= Single submitter
p.Ile648Val Single submitter
p.Ser901= Single submitter

Uncertain significance 92

c.2059-1G>C Single submitter
c.2532+3A>G Single submitter
p.Ala653Thr Single submitter ⚠
p.Ala771Val Single submitter ⚠
p.Ala884Thr Single submitter ⚠
p.Arg134Gln Single submitter ⚠
p.Arg172Lys Single submitter ⚠
p.Arg177His Single submitter ⚠
p.Arg177Pro Single submitter ⚠
p.Arg193Cys Single submitter ⚠
p.Arg213Lys Single submitter ⚠
p.Arg555Gln Single submitter ⚠
p.Arg597Cys Single submitter ⚠
p.Arg639Trp Single submitter ⚠
p.Arg798His Single submitter ⚠
p.Arg855Gln Single submitter ⚠
p.Arg855Pro Single submitter ⚠
p.Arg870Gln Single submitter ⚠
p.Arg935fs Single submitter
p.Arg947His Single submitter ⚠
p.Asn170Ser Single submitter ⚠
p.Asn477His Single submitter ⚠
p.Asn514Ser Single submitter ⚠
p.Asn545Ser Single submitter ⚠
p.Asp156Val Single submitter ⚠
p.Asp316Glu Single submitter ⚠
p.Asp74Glu Single submitter ⚠
p.Asp769Gly Single submitter ⚠
p.Gln334His Single submitter ⚠
p.Gln455Glu Single submitter
p.Gln626His Single submitter ⚠
p.Gln752Glu Single submitter
p.Glu498Asp Single submitter ⚠
p.Glu768Gln Single submitter
p.Glu844Gln Single submitter ⚠
p.Glu894Ala Single submitter ⚠
p.Gly368Asp Single submitter ⚠
p.Gly391Asp Single submitter ⚠
p.Gly882Asp Single submitter ⚠
p.His263Arg Single submitter ⚠
p.His888Arg Single submitter ⚠
p.Ile110Leu Single submitter ⚠
p.Ile628Val Single submitter ⚠
p.Ile756Val Single submitter
p.Ile804Leu Single submitter ⚠
p.Leu787Phe Single submitter ⚠
p.Leu815His Single submitter ⚠
p.Leu990Val Single submitter ⚠
p.Lys474Asn Single submitter ⚠
p.Lys533Gln Single submitter ⚠
p.Lys741Gln Single submitter ⚠
p.Met467Val Single submitter ⚠
p.Met774Ile Single submitter ⚠
p.Phe10Leu Single submitter ⚠
p.Phe68Leu Single submitter ⚠
p.Pro218Ser Single submitter ⚠
p.Pro287Ser Single submitter ⚠
p.Pro335Ser Single submitter ⚠
p.Pro349fs Single submitter
p.Pro355Thr Single submitter ⚠
p.Pro356Gln Single submitter ⚠
p.Pro369Thr Single submitter ⚠
p.Pro383Ser Single submitter ⚠
p.Pro386Ala Single submitter ⚠
p.Pro419Ala Single submitter ⚠
p.Pro502Ala Single submitter ⚠
p.Ser178Thr Single submitter ⚠
p.Ser18Gly Single submitter ⚠
p.Ser18Thr Single submitter ⚠
p.Ser444Cys Single submitter ⚠
p.Ser657Phe Single submitter ⚠
p.Ser901Asn Single submitter ⚠
p.Ser92Thr Single submitter ⚠
p.Ser965Thr Single submitter ⚠
p.Thr111Ile Single submitter ⚠
p.Thr254Ala Single submitter ⚠
p.Thr268Ile Single submitter ⚠
p.Thr400Ala Single submitter ⚠
p.Thr427Ala Single submitter ⚠
p.Thr430Ala Single submitter ⚠
p.Thr609Ile Single submitter ⚠
p.Thr785Ile Single submitter ⚠
p.Thr899Met Single submitter ⚠
p.Thr962Ala Single submitter ⚠
p.Trp187Arg Single submitter ⚠
p.Val452Leu Single submitter ⚠
p.Val539Leu Single submitter ⚠
p.Val601Ile Single submitter
p.Val624Gly Single submitter ⚠
p.Val76Leu Single submitter ⚠
p.Val791Ile Single submitter ⚠
p.Val967Ala Single submitter ⚠