RCN1 — 43 ClinVar variants
All ClinVar germline RCN1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
1 Conflicting · 2 Benign · 1 Likely benign · 39 Uncertain significance
Full RCN1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RCN1 p.Arg114Ser Uncertain significance Single submitter
- RCN1 p.Arg170Cys Uncertain significance Single submitter
- RCN1 p.Arg170His Uncertain significance Single submitter
- RCN1 p.Arg249Trp Uncertain significance Single submitter
- RCN1 p.Arg256Trp Uncertain significance Single submitter
- RCN1 p.Asp157Asn Uncertain significance Single submitter
- RCN1 p.Asp92Asn Uncertain significance Single submitter
- RCN1 p.Glu304Lys Uncertain significance Single submitter
- RCN1 p.Gly321Arg Uncertain significance Single submitter
- RCN1 p.His156Tyr Uncertain significance Single submitter
- RCN1 p.His271Gln Uncertain significance Single submitter
- RCN1 p.His287Arg Uncertain significance Single submitter
- RCN1 p.Ile305Thr Uncertain significance Single submitter
- RCN1 p.Ile305Val Uncertain significance Single submitter
- RCN1 p.Leu264Phe Uncertain significance Single submitter
- RCN1 p.Leu288Val Uncertain significance Single submitter
- RCN1 p.Lys176Arg Uncertain significance Single submitter
- RCN1 p.Pro152Leu Uncertain significance Single submitter
- RCN1 p.Thr101Ser Uncertain significance Single submitter
- RCN1 p.Thr106Ile Uncertain significance Single submitter
- RCN1 p.Thr187Ala Uncertain significance Single submitter
- RCN1 p.Thr192Ser Uncertain significance Single submitter
- RCN1 p.Thr301Ile Uncertain significance Single submitter
- RCN1 p.Trp107Cys Uncertain significance Single submitter
- RCN1 p.Trp137Arg Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- RCN1 p.Ala230Val Uncertain significance Single submitter
- RCN1 p.Arg188Trp Uncertain significance Single submitter
- RCN1 p.Arg270Cys Uncertain significance Single submitter
- RCN1 p.Asn319Ser Uncertain significance Single submitter
- RCN1 p.Gly262Arg Uncertain significance Single submitter
- RCN1 p.His202Asn Uncertain significance Single submitter
- RCN1 p.Ile87Val Uncertain significance Single submitter
- RCN1 p.Leu324Ile Uncertain significance Single submitter
- RCN1 p.Lys134Glu Uncertain significance Single submitter
- RCN1 p.Phe233Val Uncertain significance Single submitter
- RCN1 p.Thr101Ile Uncertain significance Single submitter
- RCN1 p.Tyr147Cys Uncertain significance Single submitter
- RCN1 p.Val88Phe Uncertain significance Single submitter
All RCN1 variants
Conflicting classifications of pathogenicity 1
- p.Gly219Arg Single submitter ⚠
Benign 2
- p.Ala153Thr Multiple submitters
- p.Val313= Multiple submitters
Likely benign 1
- p.Asp231= Single submitter
Uncertain significance 39
- p.Ala230Val Single submitter ⚠
- p.Arg114Ser Single submitter ⚠
- p.Arg170Cys Single submitter ⚠
- p.Arg170His Single submitter ⚠
- p.Arg188Trp Single submitter ⚠
- p.Arg249Gln Single submitter
- p.Arg249Trp Single submitter ⚠
- p.Arg256Trp Single submitter ⚠
- p.Arg270Cys Single submitter ⚠
- p.Asn319Ser Single submitter ⚠
- p.Asp157Asn Single submitter ⚠
- p.Asp92Asn Single submitter ⚠
- p.Glu304Lys Single submitter ⚠
- p.Gly262Arg Single submitter ⚠
- p.Gly321Arg Single submitter ⚠
- p.His156Tyr Single submitter ⚠
- p.His202Asn Single submitter ⚠
- p.His271Gln Single submitter ⚠
- p.His287Arg Single submitter ⚠
- p.Ile305Thr Single submitter ⚠
- p.Ile305Val Single submitter ⚠
- p.Ile87Val Single submitter ⚠
- p.Leu264Phe Single submitter ⚠
- p.Leu288Val Single submitter ⚠
- p.Leu324Ile Single submitter ⚠
- p.Lys134Glu Single submitter ⚠
- p.Lys176Arg Single submitter ⚠
- p.Phe233Val Single submitter ⚠
- p.Pro152Leu Single submitter ⚠
- p.Thr101Ile Single submitter ⚠
- p.Thr101Ser Single submitter ⚠
- p.Thr106Ile Single submitter ⚠
- p.Thr187Ala Single submitter ⚠
- p.Thr192Ser Single submitter ⚠
- p.Thr301Ile Single submitter ⚠
- p.Trp107Cys Single submitter ⚠
- p.Trp137Arg Single submitter ⚠
- p.Tyr147Cys Single submitter ⚠
- p.Val88Phe Single submitter ⚠