Sugi Variant

Sugi Variant/RFWD3

RFWD3 — 696 ClinVar variants

All ClinVar germline RFWD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 377 flagged for review →

2 Pathogenic · 1 Likely pathogenic · 14 Conflicting · 16 Benign · 6 Benign/Likely benign · 230 Likely benign · 427 Uncertain significance

Full RFWD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 377

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 13

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 309

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 309

Predictors split 55

The independent predictors disagree with each other — read with care.

All RFWD3 variants

Pathogenic 2

Likely pathogenic 1

Conflicting classifications of pathogenicity 14

Benign 16

Benign/Likely benign 6

Likely benign 230

Uncertain significance 427

Showing the top 300 by review status; the full set is in the sitemap.