RGS17 — 17 ClinVar variants
All ClinVar germline RGS17 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
17 Uncertain significance
Full RGS17 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RGS17 p.Ala18Val Uncertain significance Single submitter
- RGS17 p.Arg103Gln Uncertain significance Single submitter
- RGS17 p.Asn25Ser Uncertain significance Single submitter
- RGS17 p.Asn51Asp Uncertain significance Single submitter
- RGS17 p.Asp139Asn Uncertain significance Single submitter
- RGS17 p.Glu100Asp Uncertain significance Single submitter
- RGS17 p.Gly49Ala Uncertain significance Single submitter
- RGS17 p.Leu102Val Uncertain significance Single submitter
- RGS17 p.Lys147Gln Uncertain significance Single submitter
- RGS17 p.Lys87Glu Uncertain significance Single submitter
- RGS17 p.Pro13Ala Uncertain significance Single submitter
- RGS17 p.Pro73Ser Uncertain significance Single submitter
- RGS17 p.Thr180Ala Uncertain significance Single submitter
- RGS17 p.Val200Leu Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All RGS17 variants
Uncertain significance 17
- p.Ala18Val Single submitter ⚠
- p.Arg103Gln Single submitter ⚠
- p.Arg2Gln Single submitter ⚠
- p.Asn125His Single submitter ⚠
- p.Asn25Ser Single submitter ⚠
- p.Asn51Asp Single submitter ⚠
- p.Asp139Asn Single submitter ⚠
- p.Glu100Asp Single submitter ⚠
- p.Gly49Ala Single submitter ⚠
- p.Leu102Val Single submitter ⚠
- p.Lys147Gln Single submitter ⚠
- p.Lys87Glu Single submitter ⚠
- p.Pro13Ala Single submitter ⚠
- p.Pro73Ser Single submitter ⚠
- p.Thr180Ala Single submitter ⚠
- p.Tyr179His Single submitter ⚠
- p.Val200Leu Single submitter ⚠