RIPK2 — 50 ClinVar variants
All ClinVar germline RIPK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
4 Benign · 5 Likely benign · 41 Uncertain significance
Full RIPK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RIPK2 p.Ala263Thr Uncertain significance Single submitter
- RIPK2 p.Ala405Val Uncertain significance Single submitter
- RIPK2 p.Arg123Cys Uncertain significance Single submitter
- RIPK2 p.Arg264Cys Uncertain significance Single submitter
- RIPK2 p.Arg430His Uncertain significance Single submitter
- RIPK2 p.Asn104Asp Uncertain significance Single submitter
- RIPK2 p.Asn86Ser Uncertain significance Single submitter
- RIPK2 p.Asp371Asn Uncertain significance Single submitter
- RIPK2 p.Asp371Val Uncertain significance Single submitter
- RIPK2 p.Cys407Arg Uncertain significance Single submitter
- RIPK2 p.Gln350Arg Uncertain significance Single submitter
- RIPK2 p.Gln378Glu Uncertain significance Single submitter
- RIPK2 p.Glu157Gly Uncertain significance Single submitter
- RIPK2 p.Gly272Glu Uncertain significance Single submitter
- RIPK2 p.His126Tyr Uncertain significance Single submitter
- RIPK2 p.His246Tyr Uncertain significance Single submitter
- RIPK2 p.His261Tyr Uncertain significance Single submitter
- RIPK2 p.Ile307Thr Uncertain significance Single submitter
- RIPK2 p.Ile78Asn Uncertain significance Single submitter
- RIPK2 p.Lys376Thr Uncertain significance Single submitter
- RIPK2 p.Met172Thr Uncertain significance Single submitter
- RIPK2 p.Met172Val Uncertain significance Single submitter
- RIPK2 p.Met383Val Uncertain significance Single submitter
- RIPK2 p.Pro433Ser Uncertain significance Single submitter
- RIPK2 p.Pro88Ala Uncertain significance Single submitter
- RIPK2 p.Ser241Asn Uncertain significance Single submitter
- RIPK2 p.Ser254Asn Uncertain significance Single submitter
- RIPK2 p.Ser316Asn Uncertain significance Single submitter
- RIPK2 p.Ser355Thr Uncertain significance Single submitter
- RIPK2 p.Ser428Ala Uncertain significance Single submitter
- RIPK2 p.Ser442Asn Uncertain significance Single submitter
- RIPK2 p.Ser459Leu Uncertain significance Single submitter
- RIPK2 p.Ser465Cys Uncertain significance Single submitter
- RIPK2 p.Thr312Ile Uncertain significance Single submitter
- RIPK2 p.Thr411Ala Uncertain significance Single submitter
- RIPK2 p.Thr411Ser Uncertain significance Single submitter
- RIPK2 p.Val337Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All RIPK2 variants
Benign 4
- p.Leu268Val Multiple submitters
- p.Ser204= Multiple submitters
- c.1029+23_1029+25del Single submitter
- c.1029+25dup Single submitter
Likely benign 5
- p.Ala377Thr Single submitter
- p.Arg264His Single submitter
- p.Asn100= Single submitter
- p.Ile250Thr Single submitter ⚠
- p.Thr424Ala Single submitter
Uncertain significance 41
- p.Ala263Thr Single submitter ⚠
- p.Ala405Val Single submitter ⚠
- p.Arg123Cys Single submitter ⚠
- p.Arg171His Single submitter ⚠
- p.Arg264Cys Single submitter ⚠
- p.Arg430His Single submitter ⚠
- p.Asn104Asp Single submitter ⚠
- p.Asn86Ser Single submitter ⚠
- p.Asp371Asn Single submitter ⚠
- p.Asp371Val Single submitter ⚠
- p.Cys407Arg Single submitter ⚠
- p.Gln350Arg Single submitter ⚠
- p.Gln378Glu Single submitter ⚠
- p.Glu157Gly Single submitter ⚠
- p.Gly272Glu Single submitter ⚠
- p.His126Tyr Single submitter ⚠
- p.His246Tyr Single submitter ⚠
- p.His261Tyr Single submitter ⚠
- p.Ile307Thr Single submitter ⚠
- p.Ile78Asn Single submitter ⚠
- p.Leu49Arg Single submitter ⚠
- p.Lys169Glu Single submitter ⚠
- p.Lys376Thr Single submitter ⚠
- p.Met172Thr Single submitter ⚠
- p.Met172Val Single submitter ⚠
- p.Met383Val Single submitter ⚠
- p.Phe90Cys Single submitter ⚠
- p.Pro433Ser Single submitter ⚠
- p.Pro88Ala Single submitter ⚠
- p.Ser241Asn Single submitter ⚠
- p.Ser254Asn Single submitter ⚠
- p.Ser316Asn Single submitter ⚠
- p.Ser355Thr Single submitter ⚠
- p.Ser428Ala Single submitter ⚠
- p.Ser442Asn Single submitter ⚠
- p.Ser459Leu Single submitter ⚠
- p.Ser465Cys Single submitter ⚠
- p.Thr312Ile Single submitter ⚠
- p.Thr411Ala Single submitter ⚠
- p.Thr411Ser Single submitter ⚠
- p.Val337Ile Single submitter ⚠