RNASEL — 161 ClinVar variants
All ClinVar germline RNASEL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
1 Pathogenic · 3 Likely pathogenic · 1 Conflicting · 7 Benign · 2 Benign/Likely benign · 18 Likely benign · 129 Uncertain significance
Full RNASEL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RNASEL p.Ala22Glu Uncertain significance Single submitter
- RNASEL p.Ala443Thr Uncertain significance Single submitter
- RNASEL p.Ala461Val Uncertain significance Single submitter
- RNASEL p.Ala49Thr Uncertain significance Single submitter
- RNASEL p.Ala730Thr Uncertain significance Single submitter
- RNASEL p.Arg163Pro Uncertain significance Single submitter
- RNASEL p.Arg235Met Uncertain significance Single submitter
- RNASEL p.Arg310Gln Uncertain significance Single submitter
- RNASEL p.Arg400Cys Uncertain significance Single submitter
- RNASEL p.Arg597Leu Uncertain significance Single submitter
- RNASEL p.Arg608Gln Uncertain significance Single submitter
- RNASEL p.Arg651Gly Uncertain significance Single submitter
- RNASEL p.Arg88Lys Uncertain significance Single submitter
- RNASEL p.Asn8His Uncertain significance Single submitter
- RNASEL p.Asn91Ser Uncertain significance Single submitter
- RNASEL p.Asp189Ala Uncertain significance Single submitter
- RNASEL p.Asp458Glu Uncertain significance Single submitter
- RNASEL p.Asp523Asn Uncertain significance Single submitter
- RNASEL p.Asp5Val Uncertain significance Single submitter
- RNASEL p.Asp728Val Uncertain significance Single submitter
- RNASEL p.Cys576Tyr Uncertain significance Single submitter
- RNASEL p.Gln339Pro Uncertain significance Single submitter
- RNASEL p.Gln545Glu Uncertain significance Single submitter
-
RNASEL p.Gln693Glu
Uncertain significance
Single submitter
prostate cancer, hereditary, 1
- RNASEL p.Glu388Asp Uncertain significance Single submitter
- RNASEL p.Glu459Val Uncertain significance Single submitter
- RNASEL p.Glu611Asp Uncertain significance Single submitter
- RNASEL p.Gly202Asp Uncertain significance Single submitter
- RNASEL p.Gly273Val Uncertain significance Single submitter
- RNASEL p.Gly732Arg Uncertain significance Single submitter
- RNASEL p.His27Asn Uncertain significance Single submitter
- RNASEL p.Ile358Thr Uncertain significance Single submitter
- RNASEL p.Ile493Val Uncertain significance Single submitter
- RNASEL p.Ile673Val Uncertain significance Single submitter
- RNASEL p.Leu40Met Uncertain significance Single submitter
- RNASEL p.Leu78Pro Uncertain significance Single submitter
- RNASEL p.Lys326Glu Uncertain significance Single submitter
- RNASEL p.Lys337Met Uncertain significance Single submitter
- RNASEL p.Lys348Asn Uncertain significance Single submitter
- RNASEL p.Lys90Gln Uncertain significance Single submitter
- RNASEL p.Ser322Cys Uncertain significance Single submitter
- RNASEL p.Ser423Arg Uncertain significance Single submitter
- RNASEL p.Ser536Asn Uncertain significance Single submitter
- RNASEL p.Ser628Asn Uncertain significance Single submitter
-
RNASEL p.Val531Met
Uncertain significance
Single submitter
prostate cancer, hereditary, 1
- RNASEL p.Ala140Ser Uncertain significance No assertion criteria
-
RNASEL p.Ala471Val
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Asn463Ser
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Glu413Lys
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Glu424Gln
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Glu456Asp
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Glu474Asp
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Leu465Met
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Leu477Met
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Lys470Thr
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Phe469Ile
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Ser410Arg
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Ser415Gly
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Thr419Lys
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Thr435Pro
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
Predictors split 18
The independent predictors disagree with each other — read with care.
- RNASEL p.Gly59Ser Likely benign Multiple submitters
- RNASEL p.Ile74Thr Uncertain significance Multiple submitters
-
RNASEL p.Ala176Thr
Uncertain significance
Single submitter
prostate cancer, hereditary, 1
- RNASEL p.Asp604Asn Uncertain significance Single submitter
- RNASEL p.Cys407Tyr Uncertain significance Single submitter
- RNASEL p.His416Asp Uncertain significance Single submitter
- RNASEL p.Leu188Phe Uncertain significance Single submitter
- RNASEL p.Leu566Phe Uncertain significance Single submitter
- RNASEL p.Phe111Leu Uncertain significance Single submitter
- RNASEL p.Phe420Ile Uncertain significance Single submitter
- RNASEL p.Pro569His Uncertain significance Single submitter
- RNASEL p.Pro85Leu Uncertain significance Single submitter
- RNASEL p.Trp343Cys Uncertain significance Single submitter
-
RNASEL p.Arg403Pro
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Gln473Pro
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Gly422Trp
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Leu430Ser
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
-
RNASEL p.Phe469Leu
Uncertain significance
No assertion criteria
prostate cancer, hereditary, 1
All RNASEL variants
Pathogenic 1
- p.Met1Ile No assertion criteria prostate cancer, hereditary, 1
Likely pathogenic 3
- p.Ala372Asp Single submitter ovarian cancer
- p.Asn490Ser Single submitter ovarian cancer
- p.Trp632Ter Single submitter
Conflicting classifications of pathogenicity 1
- p.Glu265Ter Single submitter prostate cancer, hereditary, 1
Benign 7
- p.Asn414= Multiple submitters
- p.Ser113= Multiple submitters
- p.Gln718Lys Single submitter ovarian cancer
- p.Leu417Phe Single submitter ovarian cancer
- p.Met306Ile Single submitter ovarian cancer
- p.Val118= Single submitter
- p.Lys724= No assertion criteria RNASEL-related disorder
Benign/Likely benign 2
- p.Ile97Leu Multiple submitters
- p.Thr393= Multiple submitters
Likely benign 18
- p.Gly59Ser Multiple submitters ⚠
- p.Arg20= Single submitter
- p.Arg238Lys Single submitter
- p.Arg462Gln Single submitter Hereditary cancer
- p.Asn267Asp Single submitter
- p.Asp39Glu Single submitter
- p.Gln42= Single submitter
- p.Gly18Ser Single submitter
- p.His483= Single submitter
- p.Leu144= Single submitter
- p.Leu663= Single submitter
- p.Ser212Asn Single submitter
- p.Ser603= Single submitter
- p.Thr222= Single submitter
- p.Arg412Gly No assertion criteria RNASEL-related disorder
- p.Asn65Lys No assertion criteria RNASEL-related disorder
- p.Lys294Glu No assertion criteria RNASEL-related disorder
- p.Lys90= No assertion criteria RNASEL-related disorder
Uncertain significance 129
- p.Ile74Thr Multiple submitters ⚠
- c.1481-1G>T Single submitter prostate cancer, hereditary, 1
- c.2039+1del Single submitter prostate cancer, hereditary, 1
- p.Ala176Thr Single submitter prostate cancer, hereditary, 1 ⚠
- p.Ala22Glu Single submitter ⚠
- p.Ala345fs Single submitter prostate cancer, hereditary, 1
- p.Ala443Thr Single submitter ⚠
- p.Ala461Val Single submitter ⚠
- p.Ala49Thr Single submitter ⚠
- p.Ala730Thr Single submitter ⚠
- p.Arg163Pro Single submitter ⚠
- p.Arg235Met Single submitter ⚠
- p.Arg310Gln Single submitter ⚠
- p.Arg400Cys Single submitter ⚠
- p.Arg597Leu Single submitter ⚠
- p.Arg608Gln Single submitter ⚠
- p.Arg651Gly Single submitter ⚠
- p.Arg667Gln Single submitter
- p.Arg88Lys Single submitter ⚠
- p.Asn8His Single submitter ⚠
- p.Asn91Ser Single submitter ⚠
- p.Asp189Ala Single submitter ⚠
- p.Asp313Val Single submitter
- p.Asp458Glu Single submitter ⚠
- p.Asp523Asn Single submitter ⚠
- p.Asp5Val Single submitter ⚠
- p.Asp604Asn Single submitter ⚠
- p.Asp728Val Single submitter ⚠
- p.Cys407Tyr Single submitter ⚠
- p.Cys576Tyr Single submitter ⚠
- p.Gln339Pro Single submitter ⚠
- p.Gln545Glu Single submitter ⚠
- p.Gln619Ter Single submitter prostate cancer, hereditary, 1
- p.Gln693Glu Single submitter prostate cancer, hereditary, 1 ⚠
- p.Glu376del Single submitter prostate cancer, hereditary, 1
- p.Glu388Asp Single submitter ⚠
- p.Glu459Val Single submitter ⚠
- p.Glu611Asp Single submitter ⚠
- p.Gly148Ala Single submitter
- p.Gly202Asp Single submitter ⚠
- p.Gly273Val Single submitter ⚠
- p.Gly732Arg Single submitter ⚠
- p.His27Asn Single submitter ⚠
- p.His416Asp Single submitter ⚠
- p.Ile358Thr Single submitter ⚠
- p.Ile493Val Single submitter ⚠
- p.Ile673Val Single submitter ⚠
- p.Leu188Phe Single submitter ⚠
- p.Leu40Met Single submitter ⚠
- p.Leu566Phe Single submitter ⚠
- p.Leu78Pro Single submitter ⚠
- p.Lys326Glu Single submitter ⚠
- p.Lys337Met Single submitter ⚠
- p.Lys348Asn Single submitter ⚠
- p.Lys90Gln Single submitter ⚠
- p.Phe111Leu Single submitter ⚠
- p.Phe420Ile Single submitter ⚠
- p.Pro569His Single submitter ⚠
- p.Pro85Leu Single submitter ⚠
- p.Ser322Cys Single submitter ⚠
- p.Ser406Pro Single submitter
- p.Ser423Arg Single submitter ⚠
- p.Ser536Asn Single submitter ⚠
- p.Ser628Asn Single submitter ⚠
- p.Trp343Cys Single submitter ⚠
- p.Tyr712Cys Single submitter
- p.Val531Met Single submitter prostate cancer, hereditary, 1 ⚠
- p.Val640Gly Single submitter
- p.Ala140Ser No assertion criteria ⚠
- p.Ala471fs No assertion criteria prostate cancer, hereditary, 1
- p.Ala471Val No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Arg403Pro No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Arg412fs No assertion criteria prostate cancer, hereditary, 1
- p.Arg427fs No assertion criteria prostate cancer, hereditary, 1
- p.Arg462fs No assertion criteria prostate cancer, hereditary, 1
- p.Asn455fs No assertion criteria prostate cancer, hereditary, 1
- p.Asn463Ser No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Cys407fs No assertion criteria prostate cancer, hereditary, 1
- p.Cys437fs No assertion criteria prostate cancer, hereditary, 1
- p.Gln473Pro No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Glu413= No assertion criteria prostate cancer, hereditary, 1
- p.Glu413Lys No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Glu424Gln No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Glu438Ter No assertion criteria prostate cancer, hereditary, 1
- p.Glu451fs No assertion criteria prostate cancer, hereditary, 1
- p.Glu454fs No assertion criteria prostate cancer, hereditary, 1
- p.Glu456Asp No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Glu457fs No assertion criteria prostate cancer, hereditary, 1
- p.Glu474Asp No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Gly422Trp No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.His429fs No assertion criteria prostate cancer, hereditary, 1
- p.His448fs No assertion criteria prostate cancer, hereditary, 1
- p.Ile468fs No assertion criteria prostate cancer, hereditary, 1
- p.Leu408= No assertion criteria prostate cancer, hereditary, 1
- p.Leu408fs No assertion criteria prostate cancer, hereditary, 1
- p.Leu417fs No assertion criteria prostate cancer, hereditary, 1
- p.Leu430fs No assertion criteria prostate cancer, hereditary, 1
- p.Leu430Ser No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Leu430Ter No assertion criteria prostate cancer, hereditary, 1
- p.Leu441fs No assertion criteria prostate cancer, hereditary, 1
- p.Leu465Met No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Leu477fs No assertion criteria prostate cancer, hereditary, 1
- p.Leu477Met No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Lys470Thr No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Phe420= No assertion criteria prostate cancer, hereditary, 1
- p.Phe420fs No assertion criteria prostate cancer, hereditary, 1
- p.Phe460fs No assertion criteria prostate cancer, hereditary, 1
- p.Phe469fs No assertion criteria prostate cancer, hereditary, 1
- p.Phe469Ile No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Phe469Leu No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Ser410Arg No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Ser415Gly No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Ser423fs No assertion criteria prostate cancer, hereditary, 1
- p.Ser425fs No assertion criteria prostate cancer, hereditary, 1
- p.Ser466fs No assertion criteria prostate cancer, hereditary, 1
- p.Ser467fs No assertion criteria prostate cancer, hereditary, 1
- p.Thr419= No assertion criteria prostate cancer, hereditary, 1
- p.Thr419fs No assertion criteria prostate cancer, hereditary, 1
- p.Thr419Lys No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Thr435= No assertion criteria prostate cancer, hereditary, 1
- p.Thr435Pro No assertion criteria prostate cancer, hereditary, 1 ⚠
- p.Tyr421= No assertion criteria prostate cancer, hereditary, 1
- p.Tyr421fs No assertion criteria prostate cancer, hereditary, 1
- p.Val418fs No assertion criteria prostate cancer, hereditary, 1
- p.Val432fs No assertion criteria prostate cancer, hereditary, 1
- p.Val434fs No assertion criteria prostate cancer, hereditary, 1
- p.Val453fs No assertion criteria prostate cancer, hereditary, 1
- p.Val472= No assertion criteria prostate cancer, hereditary, 1
- p.Val472fs No assertion criteria prostate cancer, hereditary, 1