RNF10 — 100 ClinVar variants

All ClinVar germline RNF10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →

1 Benign · 4 Likely benign · 95 Uncertain significance

Full RNF10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 85

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 66

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 19

The independent predictors disagree with each other — read with care.

All RNF10 variants

Benign 1

p.Gly387Arg Multiple submitters

Likely benign 4

p.Ala198Val Single submitter
p.Arg499His Single submitter
p.Asn476Ser Single submitter
p.Phe111= Single submitter

Uncertain significance 95

p.Ala130Thr Single submitter ⚠
p.Ala409Val Single submitter ⚠
p.Ala723Thr Single submitter ⚠
p.Ala771Pro Single submitter ⚠
p.Arg378Trp Single submitter ⚠
p.Arg499Cys Single submitter ⚠
p.Arg525His Single submitter
p.Arg613His Single submitter
p.Arg62Cys Single submitter ⚠
p.Arg62His Single submitter
p.Arg65His Single submitter ⚠
p.Arg65Leu Single submitter ⚠
p.Arg67His Single submitter ⚠
p.Arg755Cys Single submitter ⚠
p.Arg82Cys Single submitter ⚠
p.Arg83Cys Single submitter ⚠
p.Asn177Lys Single submitter ⚠
p.Asn56Ser Single submitter ⚠
p.Asn646Ser Single submitter ⚠
p.Asn74Lys Single submitter
p.Asn74Ser Single submitter ⚠
p.Asp274Tyr Single submitter ⚠
p.Asp474Gly Single submitter ⚠
p.Asp724Gly Single submitter ⚠
p.Asp747Asn Single submitter ⚠
p.Cys576Trp Single submitter ⚠
p.Gln187Arg Single submitter ⚠
p.Gln295Arg Single submitter ⚠
p.Gln355Arg Single submitter ⚠
p.Gln762His Single submitter ⚠
p.Gln98Glu Single submitter ⚠
p.Glu179Gln Single submitter ⚠
p.Glu380Lys Single submitter ⚠
p.Glu411Gly Single submitter ⚠
p.Glu457Val Single submitter ⚠
p.Glu68Gln Single submitter ⚠
p.Gly102Ser Single submitter ⚠
p.Gly302Arg Single submitter ⚠
p.Gly462Arg Single submitter ⚠
p.Gly665Trp Single submitter ⚠
p.His284Tyr Single submitter ⚠
p.His342Asp Single submitter ⚠
p.Ile138Asn Single submitter ⚠
p.Ile227Val Single submitter ⚠
p.Ile634Met Single submitter ⚠
p.Ile769Leu Single submitter ⚠
p.Leu346Val Single submitter ⚠
p.Leu527Phe Single submitter ⚠
p.Leu667His Single submitter ⚠
p.Leu683Met Single submitter ⚠
p.Leu716Arg Single submitter ⚠
p.Leu776Pro Single submitter ⚠
p.Lys376Glu Single submitter ⚠
p.Lys51Arg Single submitter ⚠
p.Lys540Asn Single submitter ⚠
p.Lys73Gln Single submitter ⚠
p.Lys793Arg Single submitter ⚠
p.Phe508Tyr Single submitter
p.Phe642Leu Single submitter ⚠
p.Phe709Leu Single submitter ⚠
p.Pro223Leu Single submitter
p.Pro231Leu Single submitter ⚠
p.Pro491Arg Single submitter ⚠
p.Pro491Leu Single submitter ⚠
p.Pro658Leu Single submitter ⚠
p.Pro671Ser Single submitter ⚠
p.Pro696Leu Single submitter ⚠
p.Pro743Leu Single submitter ⚠
p.Pro743Ser Single submitter ⚠
p.Pro96Leu Single submitter ⚠
p.Ser103Gly Single submitter ⚠
p.Ser110Tyr Single submitter ⚠
p.Ser268Gly Single submitter ⚠
p.Ser336Cys Single submitter ⚠
p.Ser383Leu Single submitter ⚠
p.Ser383Trp Single submitter ⚠
p.Ser501Arg Single submitter ⚠
p.Ser542Ala Single submitter ⚠
p.Ser675Arg Single submitter
p.Ser692Gly Single submitter ⚠
p.Ser737Asn Single submitter ⚠
p.Ser750Ile Single submitter ⚠
p.Ser786Pro Single submitter ⚠
p.Thr154Met Single submitter ⚠
p.Thr205Lys Single submitter
p.Thr293Met Single submitter ⚠
p.Thr481Ser Single submitter ⚠
p.Thr493Ala Single submitter ⚠
p.Thr544Ile Single submitter ⚠
p.Tyr230Cys Single submitter ⚠
p.Tyr648His Single submitter ⚠
p.Val278Ala Single submitter ⚠
p.Val340Leu Single submitter
p.Val584Leu Single submitter ⚠
p.Val807Ala Single submitter