ROR1 — 267 ClinVar variants
All ClinVar germline ROR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 165 flagged for review →
1 Conflicting · 21 Benign · 6 Benign/Likely benign · 57 Likely benign · 182 Uncertain significance
Full ROR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 165
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 136
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ROR1 p.Ala596Ser Uncertain significance Multiple submitters
- ROR1 p.Ala833Ser Uncertain significance Multiple submitters
- ROR1 p.Ala923Gly Uncertain significance Multiple submitters
- ROR1 p.Ala923Thr Uncertain significance Multiple submitters
- ROR1 p.Ala935Val Uncertain significance Multiple submitters
- ROR1 p.Arg25His Uncertain significance Multiple submitters
- ROR1 p.Arg6Ser Uncertain significance Multiple submitters
- ROR1 p.Arg90His Uncertain significance Multiple submitters
- ROR1 p.Asn620Ser Uncertain significance Multiple submitters
- ROR1 p.Asp236Asn Uncertain significance Multiple submitters
- ROR1 p.Asp922His Uncertain significance Multiple submitters
- ROR1 p.Cys482Ser Uncertain significance Multiple submitters
- ROR1 p.Ile565Val Uncertain significance Multiple submitters
- ROR1 p.Ile597Met Uncertain significance Multiple submitters
- ROR1 p.Ile623Val Uncertain significance Multiple submitters
- ROR1 p.Leu71Val Uncertain significance Multiple submitters
- ROR1 p.Pro42Arg Uncertain significance Multiple submitters
- ROR1 p.Pro469Thr Uncertain significance Multiple submitters
-
ROR1 p.Pro547Ser
Uncertain significance
Multiple submitters
hearing loss, autosomal recessive 108
- ROR1 p.Pro808Leu Uncertain significance Multiple submitters
- ROR1 p.Ser568Tyr Uncertain significance Multiple submitters
- ROR1 p.Ser723Thr Uncertain significance Multiple submitters
- ROR1 p.Ala15Thr Uncertain significance Single submitter
- ROR1 p.Ala27Thr Uncertain significance Single submitter
- ROR1 p.Ala294Val Uncertain significance Single submitter
- ROR1 p.Ala304Val Uncertain significance Single submitter
- ROR1 p.Ala349Thr Uncertain significance Single submitter
- ROR1 p.Ala524Gly Uncertain significance Single submitter
- ROR1 p.Ala643Thr Uncertain significance Single submitter
- ROR1 p.Ala917Thr Uncertain significance Single submitter
- ROR1 p.Ala935Thr Uncertain significance Single submitter
- ROR1 p.Arg103Gln Uncertain significance Single submitter
- ROR1 p.Arg245Cys Uncertain significance Single submitter
- ROR1 p.Arg249Leu Uncertain significance Single submitter
- ROR1 p.Arg322Gln Uncertain significance Single submitter
- ROR1 p.Arg332His Uncertain significance Single submitter
- ROR1 p.Arg332Leu Uncertain significance Single submitter
- ROR1 p.Arg351His Uncertain significance Single submitter
- ROR1 p.Arg3Trp Uncertain significance Single submitter
- ROR1 p.Arg429Trp Uncertain significance Single submitter
- ROR1 p.Arg5His Uncertain significance Single submitter
- ROR1 p.Arg5Leu Uncertain significance Single submitter
- ROR1 p.Arg657Cys Uncertain significance Single submitter
- ROR1 p.Arg745Gln Uncertain significance Single submitter
- ROR1 p.Arg747Gln Uncertain significance Single submitter
- ROR1 p.Arg843Lys Uncertain significance Single submitter
- ROR1 p.Asn295Ser Uncertain significance Single submitter
- ROR1 p.Asn512Asp Uncertain significance Single submitter
- ROR1 p.Asp167Tyr Uncertain significance Single submitter
- ROR1 p.Asp672His Uncertain significance Single submitter
- ROR1 p.Asp913Val Uncertain significance Single submitter
- ROR1 p.Cys717Tyr Uncertain significance Single submitter
- ROR1 p.Cys728Phe Uncertain significance Single submitter
- ROR1 p.Gln287Arg Uncertain significance Single submitter
- ROR1 p.Gln287Glu Uncertain significance Single submitter
- ROR1 p.Gln340Arg Uncertain significance Single submitter
- ROR1 p.Gln432Glu Uncertain significance Single submitter
- ROR1 p.Gln878Arg Uncertain significance Single submitter
- ROR1 p.Glu165Lys Uncertain significance Single submitter
- ROR1 p.Glu190Gly Uncertain significance Single submitter
- ROR1 p.Glu625Asp Uncertain significance Single submitter
- ROR1 p.Glu930Val Uncertain significance Single submitter
- ROR1 p.Gly26Arg Uncertain significance Single submitter
- ROR1 p.Gly26Val Uncertain significance Single submitter
- ROR1 p.Gly366Glu Uncertain significance Single submitter
- ROR1 p.Gly558Arg Uncertain significance Single submitter
- ROR1 p.Gly800Ser Uncertain significance Single submitter
- ROR1 p.Gly895Asp Uncertain significance Single submitter
- ROR1 p.Gly8Glu Uncertain significance Single submitter
- ROR1 p.Gly927Ala Uncertain significance Single submitter
- ROR1 p.His743Arg Uncertain significance Single submitter
- ROR1 p.His926Arg Uncertain significance Single submitter
- ROR1 p.Ile111Val Uncertain significance Single submitter
- ROR1 p.Ile176Val Uncertain significance Single submitter
- ROR1 p.Ile182Thr Uncertain significance Single submitter
- ROR1 p.Ile418Val Uncertain significance Single submitter
- ROR1 p.Ile599Val Uncertain significance Single submitter
- ROR1 p.Ile664Val Uncertain significance Single submitter
- ROR1 p.Ile806Thr Uncertain significance Single submitter
- ROR1 p.Lys401Arg Uncertain significance Single submitter
- ROR1 p.Lys444Arg Uncertain significance Single submitter
- ROR1 p.Lys486Glu Uncertain significance Single submitter
- ROR1 p.Lys80Arg Uncertain significance Single submitter
- ROR1 p.Met272Val Uncertain significance Single submitter
- ROR1 p.Met303Thr Uncertain significance Single submitter
- ROR1 p.Met550Leu Uncertain significance Single submitter
- ROR1 p.Met64Val Uncertain significance Single submitter
- ROR1 p.Met704Val Uncertain significance Single submitter
- ROR1 p.Met790Val Uncertain significance Single submitter
- ROR1 p.Met888Leu Uncertain significance Single submitter
- ROR1 p.Phe381Ile Uncertain significance Single submitter
- ROR1 p.Phe520Tyr Uncertain significance Single submitter
- ROR1 p.Pro11Leu Uncertain significance Single submitter
- ROR1 p.Pro12Ser Uncertain significance Single submitter
- ROR1 p.Pro153Ala Uncertain significance Single submitter
- ROR1 p.Pro153His Uncertain significance Single submitter
- ROR1 p.Pro153Ser Uncertain significance Single submitter
- ROR1 p.Pro158Ser Uncertain significance Single submitter
- ROR1 p.Pro225Ala Uncertain significance Single submitter
- ROR1 p.Pro233Leu Uncertain significance Single submitter
- ROR1 p.Pro42Leu Uncertain significance Single submitter
- ROR1 p.Pro42Ser Uncertain significance Single submitter
- ROR1 p.Pro461Ser Uncertain significance Single submitter
- ROR1 p.Pro461Thr Uncertain significance Single submitter
- ROR1 p.Pro514Arg Uncertain significance Single submitter
- ROR1 p.Pro547Arg Uncertain significance Single submitter
- ROR1 p.Pro719Ala Uncertain significance Single submitter
- ROR1 p.Pro792Leu Uncertain significance Single submitter
- ROR1 p.Pro86Leu Uncertain significance Single submitter
- ROR1 p.Pro909Thr Uncertain significance Single submitter
- ROR1 p.Ser114Phe Uncertain significance Single submitter
- ROR1 p.Ser157Gly Uncertain significance Single submitter
- ROR1 p.Ser463Asn Uncertain significance Single submitter
- ROR1 p.Ser568Ala Uncertain significance Single submitter
- ROR1 p.Ser568Thr Uncertain significance Single submitter
- ROR1 p.Ser56Pro Uncertain significance Single submitter
- ROR1 p.Ser697Asn Uncertain significance Single submitter
- ROR1 p.Ser793Ile Uncertain significance Single submitter
- ROR1 p.Thr346Ala Uncertain significance Single submitter
- ROR1 p.Thr69Met Uncertain significance Single submitter
- ROR1 p.Thr771Ala Uncertain significance Single submitter
- ROR1 p.Thr900Ala Uncertain significance Single submitter
- ROR1 p.Thr929Ser Uncertain significance Single submitter
- ROR1 p.Tyr230Cys Uncertain significance Single submitter
- ROR1 p.Tyr459Cys Uncertain significance Single submitter
- ROR1 p.Tyr459His Uncertain significance Single submitter
- ROR1 p.Tyr488Cys Uncertain significance Single submitter
-
ROR1 p.Tyr910Asp
Uncertain significance
Single submitter
hearing loss, autosomal recessive 108
- ROR1 p.Val139Met Uncertain significance Single submitter
- ROR1 p.Val241Ile Uncertain significance Single submitter
- ROR1 p.Val325Ile Uncertain significance Single submitter
- ROR1 p.Val36Ile Uncertain significance Single submitter
- ROR1 p.Val427Ile Uncertain significance Single submitter
- ROR1 p.Val439Ile Uncertain significance Single submitter
- ROR1 p.Val542Ile Uncertain significance Single submitter
- ROR1 p.Val744Ile Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- ROR1 p.Arg474Cys Uncertain significance Multiple submitters
- ROR1 p.Ile418Thr Uncertain significance Multiple submitters
- ROR1 p.Ile802Thr Uncertain significance Multiple submitters
- ROR1 p.Ser576Arg Uncertain significance Multiple submitters
- ROR1 p.Ser858Cys Uncertain significance Multiple submitters
- ROR1 p.Arg103Trp Uncertain significance Single submitter
- ROR1 p.Arg104Lys Uncertain significance Single submitter
- ROR1 p.Arg117Gln Uncertain significance Single submitter
- ROR1 p.Arg567Ser Uncertain significance Single submitter
- ROR1 p.Arg815Leu Likely benign Single submitter
- ROR1 p.Asn780Asp Uncertain significance Single submitter
- ROR1 p.Asp250Asn Uncertain significance Single submitter
-
ROR1 p.Glu452Asp
Conflicting
Single submitter
hearing loss, autosomal recessive 108
- ROR1 p.His561Leu Uncertain significance Single submitter
- ROR1 p.Lys218Asn Uncertain significance Single submitter
- ROR1 p.Met476Ile Uncertain significance Single submitter
- ROR1 p.Met665Thr Uncertain significance Single submitter
- ROR1 p.Phe688Leu Uncertain significance Single submitter
- ROR1 p.Pro271Ser Uncertain significance Single submitter
- ROR1 p.Pro389Gln Uncertain significance Single submitter
- ROR1 p.Pro719Leu Uncertain significance Single submitter
- ROR1 p.Ser216Ala Uncertain significance Single submitter
- ROR1 p.Ser585Phe Uncertain significance Single submitter
- ROR1 p.Ser734Cys Uncertain significance Single submitter
- ROR1 p.Ser862Leu Uncertain significance Single submitter
- ROR1 p.Thr123Ile Uncertain significance Single submitter
- ROR1 p.Thr207Pro Uncertain significance Single submitter
- ROR1 p.Thr771Ile Uncertain significance Single submitter
- ROR1 p.Trp517Cys Uncertain significance Single submitter
All ROR1 variants
Conflicting classifications of pathogenicity 1
- p.Glu452Asp Single submitter hearing loss, autosomal recessive 108 ⚠
Benign 21
- c.1174+230A>G Multiple submitters
- c.1174+90G>A Multiple submitters
- c.1175-52G>A Multiple submitters
- c.610+52G>A Multiple submitters
- c.91+61C>T Multiple submitters
- c.92-173C>T Multiple submitters
- c.92-56A>G Multiple submitters
- c.-24G>A Multiple submitters
- p.Ala390= Multiple submitters hearing loss, autosomal recessive 108
- p.Glu703= Multiple submitters
- p.Leu60= Multiple submitters hearing loss, autosomal recessive 108
- p.Leu690= Multiple submitters
- p.Ser642= Multiple submitters
- p.Thr348= Multiple submitters
- p.Thr518= Multiple submitters
- p.Thr518Met Multiple submitters hearing loss, autosomal recessive 108
- p.Val451= Multiple submitters hearing loss, autosomal recessive 108
- c.164-8G>T Single submitter
- c.452-165dup Single submitter
- c.*191del Single submitter
- c.*67A>C Single submitter
Benign/Likely benign 6
- c.163+11G>T Multiple submitters
- c.610+16G>T Multiple submitters
- p.His928= Multiple submitters
- p.Leu385= Multiple submitters
- p.Pro336= Multiple submitters
- p.Thr69= Multiple submitters
Likely benign 57
- c.928+14C>T Multiple submitters
- p.Glu398= Multiple submitters
- p.Pro792= Multiple submitters
- p.Ser436= Multiple submitters
- p.Ser862= Multiple submitters
- c.1386+13G>C Single submitter
- c.163+9dup Single submitter
- c.164-20C>G Single submitter
- c.164-9_164-8del Single submitter
- c.452-10A>G Single submitter
- c.610+14A>G Single submitter
- c.91+8G>T Single submitter
- c.929-13G>A Single submitter
- p.Ala156= Single submitter
- p.Ala179= Single submitter
- p.Ala18= Single submitter
- p.Ala205= Single submitter
- p.Ala294= Single submitter
- p.Ala458= Single submitter
- p.Ala830= Single submitter
- p.Ala935= Single submitter
- p.Arg3= Single submitter
- p.Arg815Leu Single submitter ⚠
- p.Asn135= Single submitter
- p.Asn620= Single submitter
- p.Asn66= Single submitter
- p.Asp674= Single submitter
- p.Asp922= Single submitter
- p.Cys235= Single submitter
- p.Gln501= Single submitter
- p.Glu562= Single submitter
- p.Glu750= Single submitter
- p.Gly210= Single submitter
- p.His445= Single submitter
- p.His847= Single submitter
- p.Leu16= Single submitter
- p.Leu21= Single submitter
- p.Leu255= Single submitter
- p.Leu34= Single submitter
- p.Leu539= Single submitter
- p.Leu564= Single submitter
- p.Leu724= Single submitter
- p.Met790Ile Single submitter
- p.Pro233= Single submitter
- p.Pro808= Single submitter
- p.Pro838= Single submitter
- p.Pro85= Single submitter
- p.Ser436Leu Single submitter
- p.Ser748= Single submitter
- p.Ser889= Single submitter
- p.Thr324= Single submitter
- p.Thr88= Single submitter
- p.Tyr234= Single submitter
- p.Val327= Single submitter
- p.Val648= Single submitter
- c.929-7T>C No assertion criteria ROR1-related disorder
- p.Val98= No assertion criteria ROR1-related disorder
Uncertain significance 182
- p.Ala596Ser Multiple submitters ⚠
- p.Ala833Ser Multiple submitters ⚠
- p.Ala923Gly Multiple submitters ⚠
- p.Ala923Thr Multiple submitters ⚠
- p.Ala935Val Multiple submitters ⚠
- p.Arg25His Multiple submitters ⚠
- p.Arg429Gln Multiple submitters
- p.Arg474Cys Multiple submitters ⚠
- p.Arg474His Multiple submitters
- p.Arg6Ser Multiple submitters ⚠
- p.Arg90His Multiple submitters ⚠
- p.Asn620Ser Multiple submitters ⚠
- p.Asp236Asn Multiple submitters ⚠
- p.Asp922His Multiple submitters ⚠
- p.Cys482Ser Multiple submitters ⚠
- p.Ile418Thr Multiple submitters ⚠
- p.Ile565Val Multiple submitters ⚠
- p.Ile597Met Multiple submitters ⚠
- p.Ile623Val Multiple submitters ⚠
- p.Ile802Thr Multiple submitters ⚠
- p.Leu71Val Multiple submitters ⚠
- p.Pro42Arg Multiple submitters ⚠
- p.Pro469Thr Multiple submitters ⚠
- p.Pro547Ser Multiple submitters hearing loss, autosomal recessive 108 ⚠
- p.Pro808Leu Multiple submitters ⚠
- p.Ser568Tyr Multiple submitters ⚠
- p.Ser576Arg Multiple submitters ⚠
- p.Ser723Thr Multiple submitters ⚠
- p.Ser858Cys Multiple submitters ⚠
- p.Thr328Ser Multiple submitters
- c.163+1G>A Single submitter
- p.Ala15Thr Single submitter ⚠
- p.Ala18_Leu21dup Single submitter
- p.Ala27Thr Single submitter ⚠
- p.Ala294Val Single submitter ⚠
- p.Ala304Val Single submitter ⚠
- p.Ala349Thr Single submitter ⚠
- p.Ala524Gly Single submitter ⚠
- p.Ala643Thr Single submitter ⚠
- p.Ala917Thr Single submitter ⚠
- p.Ala935Thr Single submitter ⚠
- p.Arg103Gln Single submitter ⚠
- p.Arg103Trp Single submitter ⚠
- p.Arg104Lys Single submitter ⚠
- p.Arg108Gln Single submitter
- p.Arg117Gln Single submitter ⚠
- p.Arg185Ser Single submitter
- p.Arg245Cys Single submitter ⚠
- p.Arg249His Single submitter
- p.Arg249Leu Single submitter ⚠
- p.Arg298Gln Single submitter
- p.Arg322Gln Single submitter ⚠
- p.Arg332His Single submitter ⚠
- p.Arg332Leu Single submitter ⚠
- p.Arg351His Single submitter ⚠
- p.Arg3Trp Single submitter ⚠
- p.Arg429Trp Single submitter ⚠
- p.Arg567Ser Single submitter ⚠
- p.Arg5His Single submitter ⚠
- p.Arg5Leu Single submitter ⚠
- p.Arg657Cys Single submitter ⚠
- p.Arg745Gln Single submitter ⚠
- p.Arg745Trp Single submitter
- p.Arg747Gln Single submitter ⚠
- p.Arg843Lys Single submitter ⚠
- p.Asn295Ser Single submitter ⚠
- p.Asn512Asp Single submitter ⚠
- p.Asn780Asp Single submitter ⚠
- p.Asp167Tyr Single submitter ⚠
- p.Asp250Asn Single submitter ⚠
- p.Asp284His Single submitter
- p.Asp672His Single submitter ⚠
- p.Asp913Val Single submitter ⚠
- p.Cys717Tyr Single submitter ⚠
- p.Cys728Phe Single submitter ⚠
- p.Gln287Arg Single submitter ⚠
- p.Gln287Glu Single submitter ⚠
- p.Gln340Arg Single submitter ⚠
- p.Gln432Glu Single submitter ⚠
- p.Gln878Arg Single submitter ⚠
- p.Glu165Lys Single submitter ⚠
- p.Glu166del Single submitter
- p.Glu190Gly Single submitter ⚠
- p.Glu625Asp Single submitter ⚠
- p.Glu715Lys Single submitter
- p.Glu930Val Single submitter ⚠
- p.Gly26Arg Single submitter ⚠
- p.Gly26Val Single submitter ⚠
- p.Gly366Glu Single submitter ⚠
- p.Gly558Arg Single submitter ⚠
- p.Gly800Ser Single submitter ⚠
- p.Gly895Asp Single submitter ⚠
- p.Gly8Glu Single submitter ⚠
- p.Gly927Ala Single submitter ⚠
- p.His561Leu Single submitter ⚠
- p.His743Arg Single submitter ⚠
- p.His926Arg Single submitter ⚠
- p.Ile111Val Single submitter ⚠
- p.Ile176Val Single submitter ⚠
- p.Ile182Thr Single submitter ⚠
- p.Ile418Val Single submitter ⚠
- p.Ile599Val Single submitter ⚠
- p.Ile664Val Single submitter ⚠
- p.Ile806Thr Single submitter ⚠
- p.Ile817Val Single submitter
- p.Lys218Asn Single submitter ⚠
- p.Lys401Arg Single submitter ⚠
- p.Lys444Arg Single submitter ⚠
- p.Lys486Glu Single submitter ⚠
- p.Lys80Arg Single submitter ⚠
- p.Met272Val Single submitter ⚠
- p.Met275del Single submitter
- p.Met303Thr Single submitter ⚠
- p.Met476Ile Single submitter ⚠
- p.Met497Thr Single submitter
- p.Met550Leu Single submitter ⚠
- p.Met64Val Single submitter ⚠
- p.Met665Thr Single submitter ⚠
- p.Met704Val Single submitter ⚠
- p.Met790Val Single submitter ⚠
- p.Met888Leu Single submitter ⚠
- p.Phe381Ile Single submitter ⚠
- p.Phe520Tyr Single submitter ⚠
- p.Phe688Leu Single submitter ⚠
- p.Pro11Leu Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Pro153Ala Single submitter ⚠
- p.Pro153His Single submitter ⚠
- p.Pro153Ser Single submitter ⚠
- p.Pro158Ser Single submitter ⚠
- p.Pro225Ala Single submitter ⚠
- p.Pro233Leu Single submitter ⚠
- p.Pro271Ser Single submitter ⚠
- p.Pro389Gln Single submitter ⚠
- p.Pro42Leu Single submitter ⚠
- p.Pro42Ser Single submitter ⚠
- p.Pro461Ser Single submitter ⚠
- p.Pro461Thr Single submitter ⚠
- p.Pro514Arg Single submitter ⚠
- p.Pro547Arg Single submitter ⚠
- p.Pro719Ala Single submitter ⚠
- p.Pro719Leu Single submitter ⚠
- p.Pro792Leu Single submitter ⚠
- p.Pro86Leu Single submitter ⚠
- p.Pro909Thr Single submitter ⚠
- p.Ser114Phe Single submitter ⚠
- p.Ser157Gly Single submitter ⚠
- p.Ser216Ala Single submitter ⚠
- p.Ser290Asn Single submitter
- p.Ser463Asn Single submitter ⚠
- p.Ser568Ala Single submitter ⚠
- p.Ser568Thr Single submitter ⚠
- p.Ser56Pro Single submitter ⚠
- p.Ser585Phe Single submitter ⚠
- p.Ser697Asn Single submitter ⚠
- p.Ser734Cys Single submitter ⚠
- p.Ser793Ile Single submitter ⚠
- p.Ser862Leu Single submitter ⚠
- p.Thr123Ile Single submitter ⚠
- p.Thr207Pro Single submitter ⚠
- p.Thr262fs Single submitter
- p.Thr346Ala Single submitter ⚠
- p.Thr69Met Single submitter ⚠
- p.Thr771Ala Single submitter ⚠
- p.Thr771Ile Single submitter ⚠
- p.Thr900Ala Single submitter ⚠
- p.Thr929Ser Single submitter ⚠
- p.Trp517Cys Single submitter ⚠
- p.Tyr230Cys Single submitter ⚠
- p.Tyr459Cys Single submitter ⚠
- p.Tyr459His Single submitter ⚠
- p.Tyr488Cys Single submitter ⚠
- p.Tyr910Asp Single submitter hearing loss, autosomal recessive 108 ⚠
- p.Val139Met Single submitter ⚠
- p.Val241Ile Single submitter ⚠
- p.Val325Ile Single submitter ⚠
- p.Val36Ile Single submitter ⚠
- p.Val427Ile Single submitter ⚠
- p.Val439Ile Single submitter ⚠
- p.Val542Ile Single submitter ⚠
- p.Val744Ile Single submitter ⚠
- p.Val778Met Single submitter