RPL12 — 16 ClinVar variants
All ClinVar germline RPL12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
16 Uncertain significance
Full RPL12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPL12 p.Ala159Thr Uncertain significance Single submitter
- RPL12 p.Cys162Tyr Uncertain significance Single submitter
- RPL12 p.Gly158Arg Uncertain significance Single submitter
- RPL12 p.Ile109Thr Uncertain significance Single submitter
- RPL12 p.Ile112Thr Uncertain significance Single submitter
- RPL12 p.Ile132Met Uncertain significance Single submitter
- RPL12 p.Leu28Pro Uncertain significance Single submitter
- RPL12 p.Lys86Glu Uncertain significance Single submitter
- RPL12 p.Thr105Ser Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- RPL12 p.Arg146Cys Uncertain significance Single submitter
- RPL12 p.Arg146His Uncertain significance Single submitter
- RPL12 p.Asp153Asn Uncertain significance Single submitter
- RPL12 p.Ile151Val Uncertain significance Single submitter
- RPL12 p.Ile82Val Uncertain significance Single submitter
- RPL12 p.Leu15Val Uncertain significance Single submitter
All RPL12 variants
Uncertain significance 16
- p.Ala159Thr Single submitter ⚠
- p.Ala84Gly Single submitter
- p.Arg146Cys Single submitter ⚠
- p.Arg146His Single submitter ⚠
- p.Asp153Asn Single submitter ⚠
- p.Cys162Tyr Single submitter ⚠
- p.Gly158Arg Single submitter ⚠
- p.Ile109Thr Single submitter ⚠
- p.Ile112Thr Single submitter ⚠
- p.Ile132Met Single submitter ⚠
- p.Ile151Val Single submitter ⚠
- p.Ile82Val Single submitter ⚠
- p.Leu15Val Single submitter ⚠
- p.Leu28Pro Single submitter ⚠
- p.Lys86Glu Single submitter ⚠
- p.Thr105Ser Single submitter ⚠