RPL14 — 22 ClinVar variants
All ClinVar germline RPL14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
2 Benign · 20 Uncertain significance
Full RPL14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPL14 p.Ala13Gly Uncertain significance Single submitter
- RPL14 p.Ala189Val Uncertain significance Single submitter
- RPL14 p.Ala207Val Uncertain significance Single submitter
- RPL14 p.Ala210Thr Uncertain significance Single submitter
- RPL14 p.Gln186Arg Uncertain significance Single submitter
- RPL14 p.Glu8Gln Uncertain significance Single submitter
- RPL14 p.Leu135Ile Uncertain significance Single submitter
- RPL14 p.Leu136Arg Uncertain significance Single submitter
- RPL14 p.Lys196Met Uncertain significance Single submitter
- RPL14 p.Lys23Arg Uncertain significance Single submitter
- RPL14 p.Pro162Thr Uncertain significance Single submitter
- RPL14 p.Pro192Ser Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- RPL14 p.Ala210Glu Uncertain significance Single submitter
- RPL14 p.Asn83Ser Uncertain significance Single submitter
- RPL14 p.Gly197Cys Uncertain significance Single submitter
- RPL14 p.Lys182Thr Uncertain significance Single submitter
- RPL14 p.Pro190Leu Uncertain significance Single submitter
- RPL14 p.Ser67Arg Uncertain significance Single submitter
All RPL14 variants
Benign 2
- p.Ala154_Ala159dup Single submitter
- p.Ala155_Ala159dup Single submitter
Uncertain significance 20
- p.Ala13Gly Single submitter ⚠
- p.Ala189Val Single submitter ⚠
- p.Ala207Val Single submitter ⚠
- p.Ala210Glu Single submitter ⚠
- p.Ala210Thr Single submitter ⚠
- p.Asn83Ser Single submitter ⚠
- p.Gln186Arg Single submitter ⚠
- p.Glu8Gln Single submitter ⚠
- p.Gly197Cys Single submitter ⚠
- p.Ile82Met Single submitter
- p.Leu135Ile Single submitter ⚠
- p.Leu136Arg Single submitter ⚠
- p.Lys182Thr Single submitter ⚠
- p.Lys196Met Single submitter ⚠
- p.Lys23Arg Single submitter ⚠
- p.Pro162Thr Single submitter ⚠
- p.Pro190Leu Single submitter ⚠
- p.Pro192Ser Single submitter ⚠
- p.Ser67Arg Single submitter ⚠
- p.Tyr14Cys Single submitter