RPS15 — 28 ClinVar variants

All ClinVar germline RPS15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →

2 Benign · 1 Benign/Likely benign · 16 Likely benign · 9 Uncertain significance

Full RPS15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 10

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 4

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 6

The independent predictors disagree with each other — read with care.

All RPS15 variants

Benign 2

p.Arg47Pro Multiple submitters ⚠
p.Gly117= Multiple submitters

Benign/Likely benign 1

p.Asp21= Multiple submitters

Likely benign 16

c.3+10dup Single submitter
c.3+127G>A Single submitter
c.3+172G>C Single submitter
c.325-7C>T Single submitter
c.90-19C>T Single submitter
p.Ala2= Single submitter
p.Ala39= Single submitter
p.Arg50= Single submitter
p.Arg61= Single submitter
p.Arg81= Single submitter
p.His114= Single submitter
p.His54= Single submitter
p.Ser120= Single submitter
p.Thr101Ser Single submitter ⚠
p.Thr11= Single submitter
p.Tyr30= Single submitter

Uncertain significance 9

p.Arg140Leu Single submitter ⚠
p.Arg44Trp Single submitter ⚠
p.Arg51Gly Single submitter ⚠
p.Arg51Trp Single submitter ⚠
p.Gln41Pro Single submitter ⚠
p.Gln53Pro Single submitter ⚠
p.His79Gln Single submitter ⚠
p.Leu36Val Single submitter ⚠
p.Met93Ile Single submitter