RPS8 — 19 ClinVar variants
All ClinVar germline RPS8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
1 Benign · 18 Uncertain significance
Full RPS8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPS8 p.Arg49Trp Uncertain significance Single submitter
- RPS8 p.Cys182Tyr Uncertain significance Single submitter
- RPS8 p.Gln146Glu Uncertain significance Single submitter
- RPS8 p.Gln181Glu Uncertain significance Single submitter
- RPS8 p.Gln181His Uncertain significance Single submitter
- RPS8 p.Ile136Thr Uncertain significance Single submitter
- RPS8 p.Ile175Met Uncertain significance Single submitter
- RPS8 p.Lys54Asn Uncertain significance Single submitter
- RPS8 p.Lys54Gln Uncertain significance Single submitter
- RPS8 p.Lys54Thr Uncertain significance Single submitter
- RPS8 p.Lys98Gln Uncertain significance Single submitter
- RPS8 p.Pro179Leu Uncertain significance Single submitter
- RPS8 p.Ser69Thr Uncertain significance Single submitter
- RPS8 p.Thr73Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All RPS8 variants
Benign 1
- p.Ile79= Multiple submitters
Uncertain significance 18
- p.Ala118Val Single submitter ⚠
- p.Ala185Val Single submitter ⚠
- p.Arg49Trp Single submitter ⚠
- p.Cys182Tyr Single submitter ⚠
- p.Gln146Glu Single submitter ⚠
- p.Gln181Glu Single submitter ⚠
- p.Gln181His Single submitter ⚠
- p.Ile136Thr Single submitter ⚠
- p.Ile175Met Single submitter ⚠
- p.Lys53Thr Single submitter ⚠
- p.Lys54Asn Single submitter ⚠
- p.Lys54Gln Single submitter ⚠
- p.Lys54Thr Single submitter ⚠
- p.Lys98Gln Single submitter ⚠
- p.Pro179Leu Single submitter ⚠
- p.Ser69Thr Single submitter ⚠
- p.Thr130Ile Single submitter ⚠
- p.Thr73Ile Single submitter ⚠