Sugi Variant

Sugi Variant/RRAS2

RRAS2 — 83 ClinVar variants

All ClinVar germline RRAS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →

1 Pathogenic · 2 Likely pathogenic · 9 Benign · 2 Benign/Likely benign · 23 Likely benign · 46 Uncertain significance

Full RRAS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 35

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 32

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 3

The independent predictors disagree with each other — read with care.

All RRAS2 variants

Pathogenic 1

Likely pathogenic 2

Benign 9

Benign/Likely benign 2

Likely benign 23

Uncertain significance 46