RRAS2 p.Val151=
c.453A>G · rs189760812 · VCV2976696
Likely benign
Single submitter
Classification
Likely benign
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
gnomAD v4.1
Rare
ultra-rare (popmax 0.0271%, eas)
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Splicing | ||
| SpliceAI | — | not assessed · no allele here is in the release |
|---|---|---|
| Constraint at this position | ||
| Conservation | phyloP -0.89 | GERP -3.3, phastCons 0.003 |
| Overall | ||
| CADD | 5.665 | PHRED · no single calibrated threshold — expert panels disagree |
Population frequency
gnomAD v4.1 · exomes + genomes
Grpmax group
0.0271%
East Asian · 12/44,242 alleles
Filtering AF
0.0156%
ClinGen BA1/BS1 input
FAF95, joint · FAF99 0.0123%
Overall
0.000752%
12/1,595,674 alleles · ultra-rare
exomes 11/1,443,314 · genomes 1/152,360 · joint denominator
Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.
Variant & gene context
- Gene
- RRAS2
- Protein
- p.Val151=
- Coding
- c.453A>G
- MANE Select
- NM_012250
- dbSNP
- rs189760812
- Type
- single nucleotide variant
- Location
- chr11:14281676 (GRCh38)
- Gene constraint
- LOEUF 1.246 · pLI 0.03 (gnomAD)
- Structure
- AlphaFold pLDDT 87.14 · 3 PDB
- Residue 151
- a β-strand
Similar variants
- RRAS2 p.Val151Ile Uncertain significance ★ ⚠ same residue
- RRAS2 p.Ala70Thr Likely pathogenic ★★★ same type
- RRAS2 p.Gln72Leu Pathogenic ★★★ same type
- RRAS2 c.409-16A>T Benign ★★★ same type
- RRAS2 p.Arg147Gln Uncertain significance ★★ ⚠ same type
- RRAS2 p.Arg191Trp Uncertain significance ★★ ⚠ same type
- RRAS2 p.Lys150Thr Uncertain significance ★★ ⚠ same type
- RRAS2 p.Pro45Ala Uncertain significance ★★ ⚠ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/rras2-p-val151 (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown