RRP15 — 30 ClinVar variants
All ClinVar germline RRP15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Benign · 29 Uncertain significance
Full RRP15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RRP15 p.Arg160Gly Uncertain significance Single submitter
- RRP15 p.Asp137Gly Uncertain significance Single submitter
- RRP15 p.Asp218Val Uncertain significance Single submitter
- RRP15 p.Asp59Asn Uncertain significance Single submitter
- RRP15 p.Asp66Val Uncertain significance Single submitter
- RRP15 p.Gln135Lys Uncertain significance Single submitter
- RRP15 p.Gln163His Uncertain significance Single submitter
- RRP15 p.Glu106Gly Uncertain significance Single submitter
- RRP15 p.Glu223Lys Uncertain significance Single submitter
- RRP15 p.Glu72Val Uncertain significance Single submitter
- RRP15 p.Lys108Glu Uncertain significance Single submitter
- RRP15 p.Lys122Arg Uncertain significance Single submitter
- RRP15 p.Lys230Thr Uncertain significance Single submitter
- RRP15 p.Lys53Asn Uncertain significance Single submitter
- RRP15 p.Met144Val Uncertain significance Single submitter
- RRP15 p.Met195Val Uncertain significance Single submitter
- RRP15 p.Ser193Ile Uncertain significance Single submitter
- RRP15 p.Ser272Ile Uncertain significance Single submitter
- RRP15 p.Thr110Ser Uncertain significance Single submitter
- RRP15 p.Thr247Met Uncertain significance Single submitter
- RRP15 p.Thr88Ala Uncertain significance Single submitter
- RRP15 p.Val113Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- RRP15 p.Arg198His Uncertain significance Single submitter
- RRP15 p.Arg250His Uncertain significance Single submitter
- RRP15 p.Asp270Tyr Uncertain significance Single submitter
- RRP15 p.Asp94Tyr Uncertain significance Single submitter
- RRP15 p.Glu159Asp Uncertain significance Single submitter
- RRP15 p.Gly169Ala Uncertain significance Single submitter
- RRP15 p.Met255Ile Uncertain significance Single submitter
All RRP15 variants
Benign 1
- p.Ser272fs Single submitter
Uncertain significance 29
- p.Arg160Gly Single submitter ⚠
- p.Arg198His Single submitter ⚠
- p.Arg250His Single submitter ⚠
- p.Asp137Gly Single submitter ⚠
- p.Asp218Val Single submitter ⚠
- p.Asp270Tyr Single submitter ⚠
- p.Asp59Asn Single submitter ⚠
- p.Asp66Val Single submitter ⚠
- p.Asp94Tyr Single submitter ⚠
- p.Gln135Lys Single submitter ⚠
- p.Gln163His Single submitter ⚠
- p.Glu106Gly Single submitter ⚠
- p.Glu159Asp Single submitter ⚠
- p.Glu223Lys Single submitter ⚠
- p.Glu72Val Single submitter ⚠
- p.Gly169Ala Single submitter ⚠
- p.Lys108Glu Single submitter ⚠
- p.Lys122Arg Single submitter ⚠
- p.Lys230Thr Single submitter ⚠
- p.Lys53Asn Single submitter ⚠
- p.Met144Val Single submitter ⚠
- p.Met195Val Single submitter ⚠
- p.Met255Ile Single submitter ⚠
- p.Ser193Ile Single submitter ⚠
- p.Ser272Ile Single submitter ⚠
- p.Thr110Ser Single submitter ⚠
- p.Thr247Met Single submitter ⚠
- p.Thr88Ala Single submitter ⚠
- p.Val113Ala Single submitter ⚠