S1PR1 — 26 ClinVar variants
All ClinVar germline S1PR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
2 Benign · 24 Uncertain significance
Full S1PR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- S1PR1 p.Ala100Thr Uncertain significance Single submitter
- S1PR1 p.Arg319His Uncertain significance Single submitter
- S1PR1 p.Arg324Leu Uncertain significance Single submitter
- S1PR1 p.Asn153Ser Uncertain significance Single submitter
- S1PR1 p.Asn240Ser Uncertain significance Single submitter
- S1PR1 p.Asp23Gly Uncertain significance Single submitter
- S1PR1 p.Asp335Gly Uncertain significance Single submitter
- S1PR1 p.Gly154Arg Uncertain significance Single submitter
- S1PR1 p.Gly305Arg Uncertain significance Single submitter
- S1PR1 p.Gly334Arg Uncertain significance Single submitter
- S1PR1 p.Ile144Val Uncertain significance Single submitter
- S1PR1 p.Ile185Val Uncertain significance Single submitter
- S1PR1 p.Ile344Met Uncertain significance Single submitter
- S1PR1 p.Ile372Val Uncertain significance Single submitter
- S1PR1 p.Ile64Met Uncertain significance Single submitter
- S1PR1 p.Pro332Leu Uncertain significance Single submitter
- S1PR1 p.Ser15Leu Uncertain significance Single submitter
- S1PR1 p.Ser190Asn Uncertain significance Single submitter
- S1PR1 p.Ser216Cys Uncertain significance Single submitter
- S1PR1 p.Ser382Thr Uncertain significance Single submitter
- S1PR1 p.Tyr110Phe Uncertain significance Single submitter
- S1PR1 p.Val298Leu Uncertain significance Single submitter
- S1PR1 p.Val378Ile Uncertain significance Single submitter
- S1PR1 p.Val51Met Uncertain significance Single submitter
All S1PR1 variants
Benign 2
- p.Ala11Asp Multiple submitters
- p.Ile217= Multiple submitters
Uncertain significance 24
- p.Ala100Thr Single submitter ⚠
- p.Arg319His Single submitter ⚠
- p.Arg324Leu Single submitter ⚠
- p.Asn153Ser Single submitter ⚠
- p.Asn240Ser Single submitter ⚠
- p.Asp23Gly Single submitter ⚠
- p.Asp335Gly Single submitter ⚠
- p.Gly154Arg Single submitter ⚠
- p.Gly305Arg Single submitter ⚠
- p.Gly334Arg Single submitter ⚠
- p.Ile144Val Single submitter ⚠
- p.Ile185Val Single submitter ⚠
- p.Ile344Met Single submitter ⚠
- p.Ile372Val Single submitter ⚠
- p.Ile64Met Single submitter ⚠
- p.Pro332Leu Single submitter ⚠
- p.Ser15Leu Single submitter ⚠
- p.Ser190Asn Single submitter ⚠
- p.Ser216Cys Single submitter ⚠
- p.Ser382Thr Single submitter ⚠
- p.Tyr110Phe Single submitter ⚠
- p.Val298Leu Single submitter ⚠
- p.Val378Ile Single submitter ⚠
- p.Val51Met Single submitter ⚠