S1PR4 — 33 ClinVar variants
All ClinVar germline S1PR4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
1 Benign/Likely benign · 3 Likely benign · 29 Uncertain significance
Full S1PR4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- S1PR4 p.Ala101Thr Uncertain significance Single submitter
- S1PR4 p.Ala114Thr Uncertain significance Single submitter
- S1PR4 p.Ala116Thr Uncertain significance Single submitter
- S1PR4 p.Ala116Val Uncertain significance Single submitter
- S1PR4 p.Ala128Thr Uncertain significance Single submitter
- S1PR4 p.Ala97Thr Uncertain significance Single submitter
- S1PR4 p.Arg112His Uncertain significance Single submitter
- S1PR4 p.Arg121Gln Uncertain significance Single submitter
- S1PR4 p.Arg362His Uncertain significance Single submitter
- S1PR4 p.Arg365Gly Uncertain significance Single submitter
- S1PR4 p.Arg370Gln Uncertain significance Single submitter
- S1PR4 p.Arg370Trp Uncertain significance Single submitter
- S1PR4 p.Arg78Gln Uncertain significance Single submitter
- S1PR4 p.Arg79His Uncertain significance Single submitter
- S1PR4 p.Asn87Lys Uncertain significance Single submitter
- S1PR4 p.Gly363Ser Uncertain significance Single submitter
- S1PR4 p.Leu105Pro Uncertain significance Single submitter
- S1PR4 p.Leu85Arg Uncertain significance Single submitter
- S1PR4 p.Met371Ile Uncertain significance Single submitter
- S1PR4 p.Met371Lys Uncertain significance Single submitter
- S1PR4 p.Thr72Asn Uncertain significance Single submitter
- S1PR4 p.Val103Met Uncertain significance Single submitter
- S1PR4 p.Val342Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All S1PR4 variants
Benign/Likely benign 1
- p.Thr95= Multiple submitters
Uncertain significance 29
- p.Ala101Thr Single submitter ⚠
- p.Ala114Thr Single submitter ⚠
- p.Ala116Thr Single submitter ⚠
- p.Ala116Val Single submitter ⚠
- p.Ala128Thr Single submitter ⚠
- p.Ala130Thr Single submitter
- p.Ala131Thr Single submitter ⚠
- p.Ala97Thr Single submitter ⚠
- p.Arg112His Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Arg362His Single submitter ⚠
- p.Arg365Gly Single submitter ⚠
- p.Arg370Gln Single submitter ⚠
- p.Arg370Trp Single submitter ⚠
- p.Arg372Trp Single submitter
- p.Arg78Gln Single submitter ⚠
- p.Arg79His Single submitter ⚠
- p.Asn87Lys Single submitter ⚠
- p.Gly141Glu Single submitter ⚠
- p.Gly363Ser Single submitter ⚠
- p.Leu105Pro Single submitter ⚠
- p.Leu125Phe Single submitter ⚠
- p.Leu85Arg Single submitter ⚠
- p.Met371Ile Single submitter ⚠
- p.Met371Lys Single submitter ⚠
- p.Thr127Ile Single submitter ⚠
- p.Thr72Asn Single submitter ⚠
- p.Val103Met Single submitter ⚠
- p.Val342Ile Single submitter ⚠