SCAMP2 — 48 ClinVar variants
All ClinVar germline SCAMP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
2 Likely benign · 46 Uncertain significance
Full SCAMP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SCAMP2 p.Ala143Pro Uncertain significance Single submitter
- SCAMP2 p.Ala325Thr Uncertain significance Single submitter
- SCAMP2 p.Ala35Glu Uncertain significance Single submitter
- SCAMP2 p.Ala35Val Uncertain significance Single submitter
- SCAMP2 p.Ala46Val Uncertain significance Single submitter
- SCAMP2 p.Ala61Val Uncertain significance Single submitter
- SCAMP2 p.Arg104Gln Uncertain significance Single submitter
- SCAMP2 p.Arg147Gln Uncertain significance Single submitter
- SCAMP2 p.Arg285Gln Uncertain significance Single submitter
- SCAMP2 p.Arg292Gln Uncertain significance Single submitter
- SCAMP2 p.Asn177Ser Uncertain significance Single submitter
- SCAMP2 p.Asn329Ser Uncertain significance Single submitter
- SCAMP2 p.Asp20Val Uncertain significance Single submitter
- SCAMP2 p.Asp244Asn Uncertain significance Single submitter
- SCAMP2 p.Asp93Asn Uncertain significance Single submitter
- SCAMP2 p.Gln25His Uncertain significance Single submitter
- SCAMP2 p.Gln53His Uncertain significance Single submitter
- SCAMP2 p.Gly241Arg Uncertain significance Single submitter
- SCAMP2 p.Gly246Val Uncertain significance Single submitter
- SCAMP2 p.Leu254Pro Uncertain significance Single submitter
- SCAMP2 p.Met157Thr Uncertain significance Single submitter
- SCAMP2 p.Phe199Cys Uncertain significance Single submitter
- SCAMP2 p.Pro196Ser Uncertain significance Single submitter
- SCAMP2 p.Pro69Arg Uncertain significance Single submitter
- SCAMP2 p.Pro74Ala Uncertain significance Single submitter
- SCAMP2 p.Ser258Tyr Uncertain significance Single submitter
- SCAMP2 p.Ser305Phe Uncertain significance Single submitter
- SCAMP2 p.Ser79Ala Uncertain significance Single submitter
- SCAMP2 p.Val13Met Uncertain significance Single submitter
- SCAMP2 p.Val182Gly Uncertain significance Single submitter
- SCAMP2 p.Val182Met Uncertain significance Single submitter
- SCAMP2 p.Val77Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- SCAMP2 p.Ala295Val Uncertain significance Single submitter
- SCAMP2 p.Ala97Gly Uncertain significance Single submitter
- SCAMP2 p.Arg101His Uncertain significance Single submitter
- SCAMP2 p.Arg147Trp Uncertain significance Single submitter
- SCAMP2 p.Asn38Ser Uncertain significance Single submitter
- SCAMP2 p.Asp213Asn Uncertain significance Single submitter
- SCAMP2 p.Glu98Lys Uncertain significance Single submitter
- SCAMP2 p.Pro12Leu Uncertain significance Single submitter
- SCAMP2 p.Ser178Arg Uncertain significance Single submitter
- SCAMP2 p.Ser22Cys Uncertain significance Single submitter
- SCAMP2 p.Trp126Gly Uncertain significance Single submitter
All SCAMP2 variants
Likely benign 2
- p.Ser245= Single submitter
- p.Thr70Ser Single submitter
Uncertain significance 46
- p.Ala143Pro Single submitter ⚠
- p.Ala295Val Single submitter ⚠
- p.Ala325Thr Single submitter ⚠
- p.Ala35Glu Single submitter ⚠
- p.Ala35Val Single submitter ⚠
- p.Ala46Val Single submitter ⚠
- p.Ala61Val Single submitter ⚠
- p.Ala97Gly Single submitter ⚠
- p.Arg101His Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg147Gln Single submitter ⚠
- p.Arg147Trp Single submitter ⚠
- p.Arg285Gln Single submitter ⚠
- p.Arg292Gln Single submitter ⚠
- p.Asn177Ser Single submitter ⚠
- p.Asn329Ser Single submitter ⚠
- p.Asn38Ser Single submitter ⚠
- p.Asp136Asn Single submitter
- p.Asp20Val Single submitter ⚠
- p.Asp213Asn Single submitter ⚠
- p.Asp244Asn Single submitter ⚠
- p.Asp93Asn Single submitter ⚠
- p.Gln146Leu Single submitter
- p.Gln25His Single submitter ⚠
- p.Gln53His Single submitter ⚠
- p.Glu98Lys Single submitter ⚠
- p.Gly241Arg Single submitter ⚠
- p.Gly246Val Single submitter ⚠
- p.Leu254Pro Single submitter ⚠
- p.Met157Thr Single submitter ⚠
- p.Phe199Cys Single submitter ⚠
- p.Pro128Leu Single submitter
- p.Pro12Leu Single submitter ⚠
- p.Pro196Ser Single submitter ⚠
- p.Pro69Arg Single submitter ⚠
- p.Pro74Ala Single submitter ⚠
- p.Ser178Arg Single submitter ⚠
- p.Ser22Cys Single submitter ⚠
- p.Ser258Tyr Single submitter ⚠
- p.Ser305Phe Single submitter ⚠
- p.Ser79Ala Single submitter ⚠
- p.Trp126Gly Single submitter ⚠
- p.Val13Met Single submitter ⚠
- p.Val182Gly Single submitter ⚠
- p.Val182Met Single submitter ⚠
- p.Val77Met Single submitter ⚠