SCAMP3 — 58 ClinVar variants
All ClinVar germline SCAMP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
1 Likely benign · 57 Uncertain significance
Full SCAMP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SCAMP3 p.Ala283Ser Uncertain significance Single submitter
- SCAMP3 p.Ala283Val Uncertain significance Single submitter
- SCAMP3 p.Ala319Val Uncertain significance Single submitter
- SCAMP3 p.Ala93Thr Uncertain significance Single submitter
- SCAMP3 p.Ala95Val Uncertain significance Single submitter
- SCAMP3 p.Arg219Cys Uncertain significance Single submitter
- SCAMP3 p.Arg219His Uncertain significance Single submitter
- SCAMP3 p.Arg226Trp Uncertain significance Single submitter
- SCAMP3 p.Arg306His Uncertain significance Single submitter
- SCAMP3 p.Arg345Gln Uncertain significance Single submitter
- SCAMP3 p.Arg5Thr Uncertain significance Single submitter
- SCAMP3 p.Asn195Ser Uncertain significance Single submitter
- SCAMP3 p.Asn334Ser Uncertain significance Single submitter
- SCAMP3 p.Asp18His Uncertain significance Single submitter
- SCAMP3 p.Gln315Arg Uncertain significance Single submitter
- SCAMP3 p.Gln70Pro Uncertain significance Single submitter
- SCAMP3 p.Gly271Asp Uncertain significance Single submitter
- SCAMP3 p.Gly8Arg Uncertain significance Single submitter
- SCAMP3 p.Ile300Val Uncertain significance Single submitter
- SCAMP3 p.Leu183His Uncertain significance Single submitter
- SCAMP3 p.Leu246Phe Uncertain significance Single submitter
- SCAMP3 p.Leu266Pro Uncertain significance Single submitter
- SCAMP3 p.Leu280Pro Uncertain significance Single submitter
- SCAMP3 p.Met221Thr Uncertain significance Single submitter
- SCAMP3 p.Pro139Leu Uncertain significance Single submitter
- SCAMP3 p.Pro139Ser Uncertain significance Single submitter
- SCAMP3 p.Pro24Ser Uncertain significance Single submitter
- SCAMP3 p.Pro347Leu Uncertain significance Single submitter
- SCAMP3 p.Pro63Leu Uncertain significance Single submitter
- SCAMP3 p.Pro80Leu Uncertain significance Single submitter
- SCAMP3 p.Ser165Cys Uncertain significance Single submitter
- SCAMP3 p.Ser227Asn Uncertain significance Single submitter
- SCAMP3 p.Ser302Ala Uncertain significance Single submitter
- SCAMP3 p.Ser68Thr Uncertain significance Single submitter
- SCAMP3 p.Ser72Leu Uncertain significance Single submitter
- SCAMP3 p.Tyr304Asn Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- SCAMP3 p.Ala12Pro Uncertain significance Single submitter
- SCAMP3 p.Ala283Thr Uncertain significance Single submitter
- SCAMP3 p.Ala93Pro Uncertain significance Single submitter
- SCAMP3 p.Arg108Trp Uncertain significance Single submitter
- SCAMP3 p.Arg115Gln Uncertain significance Single submitter
- SCAMP3 p.Arg118Gly Uncertain significance Single submitter
- SCAMP3 p.Arg131Pro Uncertain significance Single submitter
- SCAMP3 p.Arg299Gln Uncertain significance Single submitter
- SCAMP3 p.Arg299Trp Uncertain significance Single submitter
- SCAMP3 p.Cys147Trp Uncertain significance Single submitter
- SCAMP3 p.Ile152Phe Uncertain significance Single submitter
- SCAMP3 p.Met167Thr Uncertain significance Single submitter
- SCAMP3 p.Phe11Leu Uncertain significance Single submitter
- SCAMP3 p.Ser140Phe Uncertain significance Single submitter
- SCAMP3 p.Ser153Phe Uncertain significance Single submitter
- SCAMP3 p.Thr330Ile Uncertain significance Single submitter
- SCAMP3 p.Thr96Ile Uncertain significance Single submitter
- SCAMP3 p.Tyr41Cys Uncertain significance Single submitter
All SCAMP3 variants
Likely benign 1
- p.Pro269Leu Single submitter
Uncertain significance 57
- p.Ala12Pro Single submitter ⚠
- p.Ala283Ser Single submitter ⚠
- p.Ala283Thr Single submitter ⚠
- p.Ala283Val Single submitter ⚠
- p.Ala319Val Single submitter ⚠
- p.Ala93Pro Single submitter ⚠
- p.Ala93Thr Single submitter ⚠
- p.Ala95Val Single submitter ⚠
- p.Arg108Trp Single submitter ⚠
- p.Arg115Gln Single submitter ⚠
- p.Arg118Gly Single submitter ⚠
- p.Arg131Pro Single submitter ⚠
- p.Arg219Cys Single submitter ⚠
- p.Arg219His Single submitter ⚠
- p.Arg226Trp Single submitter ⚠
- p.Arg299Gln Single submitter ⚠
- p.Arg299Trp Single submitter ⚠
- p.Arg305His Single submitter
- p.Arg306His Single submitter ⚠
- p.Arg345Gln Single submitter ⚠
- p.Arg5Thr Single submitter ⚠
- p.Asn195Ser Single submitter ⚠
- p.Asn334Ser Single submitter ⚠
- p.Asp18His Single submitter ⚠
- p.Cys147Trp Single submitter ⚠
- p.Gln315Arg Single submitter ⚠
- p.Gln70Pro Single submitter ⚠
- p.Gly271Asp Single submitter ⚠
- p.Gly308Ser Single submitter
- p.Gly8Arg Single submitter ⚠
- p.Ile152Phe Single submitter ⚠
- p.Ile300Val Single submitter ⚠
- p.Leu183His Single submitter ⚠
- p.Leu246Phe Single submitter ⚠
- p.Leu266Pro Single submitter ⚠
- p.Leu280Pro Single submitter ⚠
- p.Leu38Pro Single submitter
- p.Met167Thr Single submitter ⚠
- p.Met221Thr Single submitter ⚠
- p.Phe11Leu Single submitter ⚠
- p.Pro139Leu Single submitter ⚠
- p.Pro139Ser Single submitter ⚠
- p.Pro24Ser Single submitter ⚠
- p.Pro347Leu Single submitter ⚠
- p.Pro63Leu Single submitter ⚠
- p.Pro80Leu Single submitter ⚠
- p.Ser140Phe Single submitter ⚠
- p.Ser153Phe Single submitter ⚠
- p.Ser165Cys Single submitter ⚠
- p.Ser227Asn Single submitter ⚠
- p.Ser302Ala Single submitter ⚠
- p.Ser68Thr Single submitter ⚠
- p.Ser72Leu Single submitter ⚠
- p.Thr330Ile Single submitter ⚠
- p.Thr96Ile Single submitter ⚠
- p.Tyr304Asn Single submitter ⚠
- p.Tyr41Cys Single submitter ⚠