SCTR — 78 ClinVar variants
All ClinVar germline SCTR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
6 Benign · 6 Likely benign · 66 Uncertain significance
Full SCTR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SCTR p.Ala245Thr Uncertain significance Single submitter
- SCTR p.Ala375Val Uncertain significance Single submitter
- SCTR p.Arg135Gln Uncertain significance Single submitter
- SCTR p.Arg174His Uncertain significance Single submitter
- SCTR p.Arg174Leu Uncertain significance Single submitter
- SCTR p.Arg2Cys Uncertain significance Single submitter
- SCTR p.Arg2Pro Uncertain significance Single submitter
- SCTR p.Arg30Gln Uncertain significance Single submitter
- SCTR p.Arg409His Uncertain significance Single submitter
- SCTR p.Arg83Trp Uncertain significance Single submitter
- SCTR p.Arg94Trp Uncertain significance Single submitter
- SCTR p.Asn392His Uncertain significance Single submitter
- SCTR p.Asn392Ser Uncertain significance Single submitter
- SCTR p.Asp209Asn Uncertain significance Single submitter
- SCTR p.Asp33Val Uncertain significance Single submitter
- SCTR p.Asp43Glu Uncertain significance Single submitter
- SCTR p.Asp56Val Uncertain significance Single submitter
- SCTR p.Asp71Glu Uncertain significance Single submitter
- SCTR p.Cys172Ser Uncertain significance Single submitter
- SCTR p.Cys208Arg Uncertain significance Single submitter
- SCTR p.Cys66Ser Uncertain significance Single submitter
- SCTR p.Gln10Glu Uncertain significance Single submitter
- SCTR p.Glu363Gly Uncertain significance Single submitter
- SCTR p.His211Tyr Uncertain significance Single submitter
- SCTR p.His23Leu Uncertain significance Single submitter
- SCTR p.His407Gln Uncertain significance Single submitter
- SCTR p.Ile246Val Uncertain significance Single submitter
- SCTR p.Ile294Val Uncertain significance Single submitter
- SCTR p.Ile356Val Uncertain significance Single submitter
- SCTR p.Leu164Pro Uncertain significance Single submitter
- SCTR p.Leu312Phe Uncertain significance Single submitter
- SCTR p.Leu324Arg Uncertain significance Single submitter
- SCTR p.Leu57Pro Uncertain significance Single submitter
- SCTR p.Pro119Ser Uncertain significance Single submitter
- SCTR p.Pro90Leu Uncertain significance Single submitter
- SCTR p.Ser130Phe Uncertain significance Single submitter
- SCTR p.Ser202Leu Uncertain significance Single submitter
- SCTR p.Ser231Cys Uncertain significance Single submitter
- SCTR p.Ser231Phe Uncertain significance Single submitter
- SCTR p.Ser293Ala Uncertain significance Single submitter
- SCTR p.Ser426Asn Uncertain significance Single submitter
- SCTR p.Thr108Pro Uncertain significance Single submitter
- SCTR p.Thr206Ser Uncertain significance Single submitter
- SCTR p.Thr59Met Uncertain significance Single submitter
- SCTR p.Thr97Ser Uncertain significance Single submitter
- SCTR p.Trp112Arg Uncertain significance Single submitter
- SCTR p.Trp232Arg Uncertain significance Single submitter
- SCTR p.Val125Ile Uncertain significance Single submitter
- SCTR p.Val183Met Uncertain significance Single submitter
- SCTR p.Val270Ile Uncertain significance Single submitter
- SCTR p.Val386Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- SCTR p.Arg299His Uncertain significance Single submitter
- SCTR p.Arg342Thr Uncertain significance Single submitter
- SCTR p.Gly257Glu Uncertain significance Single submitter
- SCTR p.Gly65Asp Uncertain significance Single submitter
- SCTR p.His171Leu Uncertain significance Single submitter
- SCTR p.Ile294Ser Uncertain significance Single submitter
- SCTR p.Leu243Val Uncertain significance Single submitter
- SCTR p.Leu345Phe Uncertain significance Single submitter
- SCTR p.Leu345Val Uncertain significance Single submitter
- SCTR p.Met145Ile Uncertain significance Single submitter
- SCTR p.Met219Ile Uncertain significance Single submitter
- SCTR p.Phe167Leu Uncertain significance Single submitter
- SCTR p.Ser79Pro Uncertain significance Single submitter
- SCTR p.Val218Phe Uncertain significance Single submitter
All SCTR variants
Benign 6
- c.851+10C>T Multiple submitters
- p.Asp110Asn Multiple submitters
- p.Cys208= Multiple submitters
- p.Leu190= Multiple submitters
- p.Pro415= Multiple submitters
- p.Ala213= Single submitter
Likely benign 6
- p.Ala292Thr Multiple submitters
- p.Ala385= Single submitter
- p.Arg83Gln Single submitter
- p.Gln53Arg Single submitter
- p.Pro81Leu Single submitter
- p.Trp39Arg Single submitter
Uncertain significance 66
- p.Ala245Thr Single submitter ⚠
- p.Ala375Val Single submitter ⚠
- p.Arg135Gln Single submitter ⚠
- p.Arg168Trp Single submitter
- p.Arg174His Single submitter ⚠
- p.Arg174Leu Single submitter ⚠
- p.Arg299His Single submitter ⚠
- p.Arg2Cys Single submitter ⚠
- p.Arg2Pro Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg342Thr Single submitter ⚠
- p.Arg409His Single submitter ⚠
- p.Arg83Trp Single submitter ⚠
- p.Arg94Trp Single submitter ⚠
- p.Asn392His Single submitter ⚠
- p.Asn392Ser Single submitter ⚠
- p.Asp209Asn Single submitter ⚠
- p.Asp33Val Single submitter ⚠
- p.Asp43Glu Single submitter ⚠
- p.Asp56Val Single submitter ⚠
- p.Asp71Glu Single submitter ⚠
- p.Cys172Ser Single submitter ⚠
- p.Cys208Arg Single submitter ⚠
- p.Cys66Ser Single submitter ⚠
- p.Gln10Glu Single submitter ⚠
- p.Glu363Gly Single submitter ⚠
- p.Gly257Glu Single submitter ⚠
- p.Gly65Asp Single submitter ⚠
- p.His171Leu Single submitter ⚠
- p.His211Tyr Single submitter ⚠
- p.His23Leu Single submitter ⚠
- p.His407Gln Single submitter ⚠
- p.Ile246Val Single submitter ⚠
- p.Ile294Ser Single submitter ⚠
- p.Ile294Val Single submitter ⚠
- p.Ile356Val Single submitter ⚠
- p.Leu164Pro Single submitter ⚠
- p.Leu243Val Single submitter ⚠
- p.Leu312Phe Single submitter ⚠
- p.Leu324Arg Single submitter ⚠
- p.Leu345Phe Single submitter ⚠
- p.Leu345Val Single submitter ⚠
- p.Leu57Pro Single submitter ⚠
- p.Met145Ile Single submitter ⚠
- p.Met219Ile Single submitter ⚠
- p.Phe167Leu Single submitter ⚠
- p.Pro119Ser Single submitter ⚠
- p.Pro90Leu Single submitter ⚠
- p.Ser130Phe Single submitter ⚠
- p.Ser202Leu Single submitter ⚠
- p.Ser231Cys Single submitter ⚠
- p.Ser231Phe Single submitter ⚠
- p.Ser293Ala Single submitter ⚠
- p.Ser426Asn Single submitter ⚠
- p.Ser79Pro Single submitter ⚠
- p.Thr108Pro Single submitter ⚠
- p.Thr206Ser Single submitter ⚠
- p.Thr59Met Single submitter ⚠
- p.Thr97Ser Single submitter ⚠
- p.Trp112Arg Single submitter ⚠
- p.Trp232Arg Single submitter ⚠
- p.Val125Ile Single submitter ⚠
- p.Val183Met Single submitter ⚠
- p.Val218Phe Single submitter ⚠
- p.Val270Ile Single submitter ⚠
- p.Val386Ile Single submitter ⚠