SDAD1 — 103 ClinVar variants
All ClinVar germline SDAD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 88 flagged for review →
3 Benign · 3 Likely benign · 97 Uncertain significance
Full SDAD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 88
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SDAD1 p.Ala150Thr Uncertain significance Single submitter
- SDAD1 p.Ala217Ser Uncertain significance Single submitter
- SDAD1 p.Ala243Thr Uncertain significance Single submitter
- SDAD1 p.Ala64Val Uncertain significance Single submitter
- SDAD1 p.Arg463Thr Uncertain significance Single submitter
- SDAD1 p.Arg597Gln Uncertain significance Single submitter
- SDAD1 p.Arg597Gly Uncertain significance Single submitter
- SDAD1 p.Arg597Trp Uncertain significance Single submitter
- SDAD1 p.Arg601Cys Uncertain significance Single submitter
- SDAD1 p.Arg655Gln Uncertain significance Single submitter
- SDAD1 p.Arg661Gln Uncertain significance Single submitter
- SDAD1 p.Arg669Gln Uncertain significance Single submitter
- SDAD1 p.Asn154Lys Uncertain significance Single submitter
- SDAD1 p.Asn155Ser Uncertain significance Single submitter
- SDAD1 p.Asn173Ser Uncertain significance Single submitter
- SDAD1 p.Asn334Ser Uncertain significance Single submitter
- SDAD1 p.Asn36Asp Uncertain significance Single submitter
- SDAD1 p.Asn88Ile Uncertain significance Single submitter
- SDAD1 p.Asp225Asn Uncertain significance Single submitter
- SDAD1 p.Asp233Glu Uncertain significance Single submitter
- SDAD1 p.Asp238Gly Uncertain significance Single submitter
- SDAD1 p.Asp495Gly Uncertain significance Single submitter
- SDAD1 p.Asp569Glu Uncertain significance Single submitter
- SDAD1 p.Gln230Glu Uncertain significance Single submitter
- SDAD1 p.Gln648Lys Uncertain significance Single submitter
- SDAD1 p.Glu186Gly Uncertain significance Single submitter
- SDAD1 p.Glu498Lys Uncertain significance Single submitter
- SDAD1 p.Gly573Arg Uncertain significance Single submitter
- SDAD1 p.His129Arg Uncertain significance Single submitter
- SDAD1 p.His37Arg Uncertain significance Single submitter
- SDAD1 p.His437Asn Uncertain significance Single submitter
- SDAD1 p.His68Gln Uncertain significance Single submitter
- SDAD1 p.His89Asn Uncertain significance Single submitter
- SDAD1 p.Ile113Val Uncertain significance Single submitter
- SDAD1 p.Ile321Val Uncertain significance Single submitter
- SDAD1 p.Ile395Val Uncertain significance Single submitter
- SDAD1 p.Ile398Val Uncertain significance Single submitter
- SDAD1 p.Ile476Leu Uncertain significance Single submitter
- SDAD1 p.Leu502Val Uncertain significance Single submitter
- SDAD1 p.Leu614Arg Uncertain significance Single submitter
- SDAD1 p.Lys146Gln Uncertain significance Single submitter
- SDAD1 p.Lys276Glu Uncertain significance Single submitter
- SDAD1 p.Lys277Arg Uncertain significance Single submitter
- SDAD1 p.Lys308Gln Uncertain significance Single submitter
- SDAD1 p.Lys39Arg Uncertain significance Single submitter
- SDAD1 p.Lys645Arg Uncertain significance Single submitter
- SDAD1 p.Lys8Arg Uncertain significance Single submitter
- SDAD1 p.Met267Val Uncertain significance Single submitter
- SDAD1 p.Met316Ile Uncertain significance Single submitter
- SDAD1 p.Met533Val Uncertain significance Single submitter
- SDAD1 p.Met561Val Uncertain significance Single submitter
- SDAD1 p.Met686Val Uncertain significance Single submitter
- SDAD1 p.Phe100Ile Uncertain significance Single submitter
- SDAD1 p.Phe335Val Uncertain significance Single submitter
- SDAD1 p.Pro366Ala Uncertain significance Single submitter
- SDAD1 p.Pro636Ala Uncertain significance Single submitter
- SDAD1 p.Ser117Arg Uncertain significance Single submitter
- SDAD1 p.Ser322Ala Uncertain significance Single submitter
- SDAD1 p.Ser640Leu Uncertain significance Single submitter
- SDAD1 p.Thr252Ala Uncertain significance Single submitter
- SDAD1 p.Thr410Ser Uncertain significance Single submitter
- SDAD1 p.Tyr336Cys Uncertain significance Single submitter
- SDAD1 p.Val183Ile Uncertain significance Single submitter
- SDAD1 p.Val313Leu Uncertain significance Single submitter
- SDAD1 p.Val365Ile Uncertain significance Single submitter
- SDAD1 p.Val377Met Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- SDAD1 p.Ala150Glu Uncertain significance Single submitter
- SDAD1 p.Arg127Cys Uncertain significance Single submitter
- SDAD1 p.Arg666Cys Uncertain significance Single submitter
- SDAD1 p.Arg676Gln Uncertain significance Single submitter
- SDAD1 p.Asn200Ser Uncertain significance Single submitter
- SDAD1 p.Asn259Tyr Uncertain significance Single submitter
- SDAD1 p.Asn7Lys Uncertain significance Single submitter
- SDAD1 p.Asp171Glu Uncertain significance Single submitter
- SDAD1 p.Asp384Asn Uncertain significance Single submitter
- SDAD1 p.Asp493Tyr Uncertain significance Single submitter
- SDAD1 p.Glu670Lys Uncertain significance Single submitter
- SDAD1 p.Gly620Arg Uncertain significance Single submitter
- SDAD1 p.His423Leu Uncertain significance Single submitter
- SDAD1 p.Leu222Val Uncertain significance Single submitter
- SDAD1 p.Leu339Phe Uncertain significance Single submitter
- SDAD1 p.Leu673Trp Uncertain significance Single submitter
- SDAD1 p.Leu679Phe Uncertain significance Single submitter
- SDAD1 p.Lys454Asn Uncertain significance Single submitter
- SDAD1 p.Met654Thr Uncertain significance Single submitter
- SDAD1 p.Pro14Leu Uncertain significance Single submitter
- SDAD1 p.Ser67Arg Uncertain significance Single submitter
- SDAD1 p.Thr547Ile Uncertain significance Single submitter
All SDAD1 variants
Benign 3
- c.988-10C>A Single submitter
- p.Ala571= Single submitter
- p.Leu32= Single submitter
Likely benign 3
- p.Ile545Val Single submitter
- p.Leu214= Single submitter
- p.Met535Thr Single submitter
Uncertain significance 97
- p.Ala150Glu Single submitter ⚠
- p.Ala150Thr Single submitter ⚠
- p.Ala217Ser Single submitter ⚠
- p.Ala243Thr Single submitter ⚠
- p.Ala297Val Single submitter
- p.Ala64Val Single submitter ⚠
- p.Arg127Cys Single submitter ⚠
- p.Arg440Gln Single submitter
- p.Arg463Thr Single submitter ⚠
- p.Arg597Gln Single submitter ⚠
- p.Arg597Gly Single submitter ⚠
- p.Arg597Trp Single submitter ⚠
- p.Arg601Cys Single submitter ⚠
- p.Arg624Gln Single submitter
- p.Arg655Gln Single submitter ⚠
- p.Arg661Gln Single submitter ⚠
- p.Arg666Cys Single submitter ⚠
- p.Arg669Gln Single submitter ⚠
- p.Arg676Gln Single submitter ⚠
- p.Asn154Lys Single submitter ⚠
- p.Asn155Ser Single submitter ⚠
- p.Asn173Ser Single submitter ⚠
- p.Asn200Ser Single submitter ⚠
- p.Asn259Tyr Single submitter ⚠
- p.Asn334Ser Single submitter ⚠
- p.Asn36Asp Single submitter ⚠
- p.Asn396Ser Single submitter
- p.Asn7Lys Single submitter ⚠
- p.Asn88Ile Single submitter ⚠
- p.Asp171Glu Single submitter ⚠
- p.Asp225Asn Single submitter ⚠
- p.Asp233Glu Single submitter ⚠
- p.Asp238Gly Single submitter ⚠
- p.Asp384Asn Single submitter ⚠
- p.Asp493Tyr Single submitter ⚠
- p.Asp495Gly Single submitter ⚠
- p.Asp569Glu Single submitter ⚠
- p.Gln230Glu Single submitter ⚠
- p.Gln648Lys Single submitter ⚠
- p.Glu186Gly Single submitter ⚠
- p.Glu498Lys Single submitter ⚠
- p.Glu670Lys Single submitter ⚠
- p.Gly573Arg Single submitter ⚠
- p.Gly620Arg Single submitter ⚠
- p.His129Arg Single submitter ⚠
- p.His37Arg Single submitter ⚠
- p.His423Leu Single submitter ⚠
- p.His437Asn Single submitter ⚠
- p.His68Gln Single submitter ⚠
- p.His89Asn Single submitter ⚠
- p.Ile113Val Single submitter ⚠
- p.Ile321Val Single submitter ⚠
- p.Ile395Val Single submitter ⚠
- p.Ile398Val Single submitter ⚠
- p.Ile476Leu Single submitter ⚠
- p.Leu107Val Single submitter
- p.Leu222Val Single submitter ⚠
- p.Leu339Phe Single submitter ⚠
- p.Leu502Val Single submitter ⚠
- p.Leu614Arg Single submitter ⚠
- p.Leu673Trp Single submitter ⚠
- p.Leu679Phe Single submitter ⚠
- p.Lys146Gln Single submitter ⚠
- p.Lys276Glu Single submitter ⚠
- p.Lys277Arg Single submitter ⚠
- p.Lys308Gln Single submitter ⚠
- p.Lys39Arg Single submitter ⚠
- p.Lys454Asn Single submitter ⚠
- p.Lys645Arg Single submitter ⚠
- p.Lys8Arg Single submitter ⚠
- p.Met267Val Single submitter ⚠
- p.Met316Ile Single submitter ⚠
- p.Met446Lys Single submitter
- p.Met533Val Single submitter ⚠
- p.Met561Val Single submitter ⚠
- p.Met654Thr Single submitter ⚠
- p.Met686Val Single submitter ⚠
- p.Phe100Ile Single submitter ⚠
- p.Phe335Val Single submitter ⚠
- p.Pro14Leu Single submitter ⚠
- p.Pro14Ser Single submitter
- p.Pro366Ala Single submitter ⚠
- p.Pro636Ala Single submitter ⚠
- p.Ser117Arg Single submitter ⚠
- p.Ser322Ala Single submitter ⚠
- p.Ser518Tyr Single submitter
- p.Ser640Leu Single submitter ⚠
- p.Ser667Thr Single submitter
- p.Ser67Arg Single submitter ⚠
- p.Thr252Ala Single submitter ⚠
- p.Thr410Ser Single submitter ⚠
- p.Thr547Ile Single submitter ⚠
- p.Tyr336Cys Single submitter ⚠
- p.Val183Ile Single submitter ⚠
- p.Val313Leu Single submitter ⚠
- p.Val365Ile Single submitter ⚠
- p.Val377Met Single submitter ⚠