SDF4 — 75 ClinVar variants
All ClinVar germline SDF4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Benign · 5 Likely benign · 69 Uncertain significance
Full SDF4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SDF4 c.-11C>T Uncertain significance Single submitter
- SDF4 c.-18G>A Uncertain significance Single submitter
- SDF4 c.-3G>A Uncertain significance Single submitter
- SDF4 p.Ala161Val Uncertain significance Single submitter
- SDF4 p.Ala293Thr Uncertain significance Single submitter
- SDF4 p.Arg109Gln Uncertain significance Single submitter
- SDF4 p.Arg109Trp Uncertain significance Single submitter
- SDF4 p.Arg140His Uncertain significance Single submitter
- SDF4 p.Arg196Cys Uncertain significance Single submitter
- SDF4 p.Arg196Ser Uncertain significance Single submitter
- SDF4 p.Arg30Gln Uncertain significance Single submitter
- SDF4 p.Arg90Gln Uncertain significance Single submitter
- SDF4 p.Arg90Trp Uncertain significance Single submitter
- SDF4 p.Arg91Gln Uncertain significance Single submitter
- SDF4 p.Arg91Trp Uncertain significance Single submitter
- SDF4 p.Asn270Ile Uncertain significance Single submitter
- SDF4 p.Asn307Ser Uncertain significance Single submitter
- SDF4 p.Asp143Val Uncertain significance Single submitter
- SDF4 p.Asp266Glu Uncertain significance Single submitter
- SDF4 p.Asp274Asn Uncertain significance Single submitter
- SDF4 p.Asp86Glu Uncertain significance Single submitter
- SDF4 p.Cys14Trp Uncertain significance Single submitter
- SDF4 p.Gln199Arg Uncertain significance Single submitter
- SDF4 p.Glu126Lys Uncertain significance Single submitter
- SDF4 p.Glu134Asp Uncertain significance Single submitter
- SDF4 p.Glu167Lys Uncertain significance Single submitter
- SDF4 p.Glu184Gly Uncertain significance Single submitter
- SDF4 p.Glu184Lys Uncertain significance Single submitter
- SDF4 p.Glu305Gly Uncertain significance Single submitter
- SDF4 p.Glu330Gly Uncertain significance Single submitter
- SDF4 p.Glu330Lys Uncertain significance Single submitter
- SDF4 p.Glu45Asp Uncertain significance Single submitter
- SDF4 p.Glu85Gly Uncertain significance Single submitter
- SDF4 p.Glu85Lys Uncertain significance Single submitter
- SDF4 p.Gly146Glu Uncertain significance Single submitter
- SDF4 p.Gly164Asp Uncertain significance Single submitter
- SDF4 p.Gly242Ser Uncertain significance Single submitter
- SDF4 p.Gly6Asp Uncertain significance Single submitter
- SDF4 p.His138Arg Uncertain significance Single submitter
- SDF4 p.His165Arg Uncertain significance Single submitter
- SDF4 p.Ile111Val Uncertain significance Single submitter
- SDF4 p.Ile174Val Uncertain significance Single submitter
- SDF4 p.Ile267Val Uncertain significance Single submitter
- SDF4 p.Ile99Val Uncertain significance Single submitter
- SDF4 p.Leu209Pro Uncertain significance Single submitter
- SDF4 p.Leu246Phe Uncertain significance Single submitter
- SDF4 p.Leu80Arg Uncertain significance Single submitter
- SDF4 p.Met121Arg Uncertain significance Single submitter
- SDF4 p.Met300Val Uncertain significance Single submitter
- SDF4 p.Met303Thr Uncertain significance Single submitter
- SDF4 p.Phe139Leu Uncertain significance Single submitter
- SDF4 p.Pro203Leu Uncertain significance Single submitter
- SDF4 p.Pro249Ala Uncertain significance Single submitter
- SDF4 p.Pro7Arg Uncertain significance Single submitter
- SDF4 p.Pro89Leu Uncertain significance Single submitter
- SDF4 p.Thr340Ala Uncertain significance Single submitter
- SDF4 p.Tyr155Cys Uncertain significance Single submitter
- SDF4 p.Val170Ile Uncertain significance Single submitter
- SDF4 p.Val318Phe Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- SDF4 p.Ala348Val Uncertain significance Single submitter
- SDF4 p.Arg140Cys Uncertain significance Single submitter
- SDF4 p.Arg224Trp Uncertain significance Single submitter
- SDF4 p.Gly289Ser Uncertain significance Single submitter
- SDF4 p.Gly57Arg Uncertain significance Single submitter
- SDF4 p.Gly64Glu Uncertain significance Single submitter
- SDF4 p.His54Asp Uncertain significance Single submitter
- SDF4 p.Met62Ile Uncertain significance Single submitter
- SDF4 p.Thr210Met Uncertain significance Single submitter
- SDF4 p.Val150Leu Uncertain significance Single submitter
All SDF4 variants
Benign 1
- p.Ser35= Multiple submitters
Likely benign 5
- p.Ala27Val Single submitter
- p.Arg118His Single submitter
- p.Arg175Lys Single submitter
- p.Arg228Lys Single submitter
- p.Met132Val Single submitter
Uncertain significance 69
- c.-11C>T Single submitter ⚠
- c.-18G>A Single submitter ⚠
- c.-3G>A Single submitter ⚠
- p.Ala161Val Single submitter ⚠
- p.Ala293Thr Single submitter ⚠
- p.Ala348Val Single submitter ⚠
- p.Arg109Gln Single submitter ⚠
- p.Arg109Trp Single submitter ⚠
- p.Arg140Cys Single submitter ⚠
- p.Arg140His Single submitter ⚠
- p.Arg196Cys Single submitter ⚠
- p.Arg196Ser Single submitter ⚠
- p.Arg224Trp Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg90Gln Single submitter ⚠
- p.Arg90Trp Single submitter ⚠
- p.Arg91Gln Single submitter ⚠
- p.Arg91Trp Single submitter ⚠
- p.Asn270Ile Single submitter ⚠
- p.Asn307Ser Single submitter ⚠
- p.Asp143Val Single submitter ⚠
- p.Asp266Glu Single submitter ⚠
- p.Asp274Asn Single submitter ⚠
- p.Asp86Glu Single submitter ⚠
- p.Cys14Trp Single submitter ⚠
- p.Gln199Arg Single submitter ⚠
- p.Glu126Lys Single submitter ⚠
- p.Glu134Asp Single submitter ⚠
- p.Glu167Lys Single submitter ⚠
- p.Glu184Gly Single submitter ⚠
- p.Glu184Lys Single submitter ⚠
- p.Glu305Gly Single submitter ⚠
- p.Glu330Gly Single submitter ⚠
- p.Glu330Lys Single submitter ⚠
- p.Glu45Asp Single submitter ⚠
- p.Glu85Gly Single submitter ⚠
- p.Glu85Lys Single submitter ⚠
- p.Gly146Glu Single submitter ⚠
- p.Gly164Asp Single submitter ⚠
- p.Gly242Ser Single submitter ⚠
- p.Gly289Ser Single submitter ⚠
- p.Gly57Arg Single submitter ⚠
- p.Gly64Glu Single submitter ⚠
- p.Gly6Asp Single submitter ⚠
- p.His138Arg Single submitter ⚠
- p.His165Arg Single submitter ⚠
- p.His54Asp Single submitter ⚠
- p.Ile111Val Single submitter ⚠
- p.Ile174Val Single submitter ⚠
- p.Ile267Val Single submitter ⚠
- p.Ile99Val Single submitter ⚠
- p.Leu209Pro Single submitter ⚠
- p.Leu246Phe Single submitter ⚠
- p.Leu80Arg Single submitter ⚠
- p.Met121Arg Single submitter ⚠
- p.Met300Val Single submitter ⚠
- p.Met303Thr Single submitter ⚠
- p.Met62Ile Single submitter ⚠
- p.Phe139Leu Single submitter ⚠
- p.Pro203Leu Single submitter ⚠
- p.Pro249Ala Single submitter ⚠
- p.Pro7Arg Single submitter ⚠
- p.Pro89Leu Single submitter ⚠
- p.Thr210Met Single submitter ⚠
- p.Thr340Ala Single submitter ⚠
- p.Tyr155Cys Single submitter ⚠
- p.Val150Leu Single submitter ⚠
- p.Val170Ile Single submitter ⚠
- p.Val318Phe Single submitter ⚠